Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mike Aguiar"'
Autor:
Brandon M. Gassaway, Jiaming Li, Ramin Rad, Julian Mintseris, Kyle Mohler, Tyler Levy, Mike Aguiar, Sean A. Beausoleil, Joao A. Paulo, Jesse Rinehart, Edward L. Huttlin, Steven P. Gygi
Publikováno v:
Nat Methods
Mass-spectrometry-based phosphoproteomics has become indispensable for understanding cellular signaling in complex biological systems. Despite the central role of protein phosphorylation, the field still lacks inexpensive, regenerable, and diverse ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52469f1062cd0a7b82f7270dbfda982
https://europepmc.org/articles/PMC9847208/
https://europepmc.org/articles/PMC9847208/
Autor:
Lonning Scott Michael, Jianxin Xie, Mike Aguiar, Shannon Elf, Hee-Bum Kang, Martha Arellano, Tae-Wook Chung, Dong M. Shin, Changliang Shan, Fadlo R. Khuri, Titus J. Boggon, Hanna Jean Khoury, Ting-Lei Gu, Jun Fan, Taro Hitosugi
Publikováno v:
Journal of Biological Chemistry. 289:21413-21422
Many cancer cells rely more on aerobic glycolysis (the Warburg effect) than mitochondrial oxidative phosphorylation and catabolize glucose at a high rate. Such a metabolic switch is suggested to be due in part to functional attenuation of mitochondri
Publikováno v:
Journal of Biological Chemistry. 286:1074-1082
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are large, ubiquitously expressed, endoplasmic reticulum membrane proteins that form tetrameric IP(3) and Ca(2+)-gated Ca(2+) channels. Endogenous IP(3)Rs provide very appealing tools for study
Publikováno v:
Journal of Chromatography B. 818:301-308
New methods employing capillary liquid chromatography in combination with time-of-flight mass spectrometry (μLC-TOF/MS) were developed for the rapid determination of salcatonin in human urine and plasma. The present approaches utilize 13 C 6 -leucin
Autor:
Pavel Kraikivski, Karim Resaul, Steven P. Gygi, Kazuho Ikeda, Ilya Zaliapin, Irina Semenova, Vladimir Rodionov, Anne E. Cowan, Mike Aguiar
Publikováno v:
Molecular Biology of the Cell
Binding to microtubules of Xenopus microtubule-associated protein 4 (XMAP4) negatively regulates dynein-dependent movement of membrane organelles and positively regulates kinesin-2–based movement. Phosphorylation reduces binding of XMAP4 to microtu
Autor:
Lonning Scott Michael, Hanna Jean Khoury, Sumin Kang, Mike Aguiar, Ruiting Lin, Jianxin Xie, Martha Arellano, Titus J. Boggon, Changliang Shan, Hee-Bum Kang, Shannon Elf, Dong M. Shin, Jun Fan, Ting-Lei Gu, Fadlo R. Khuri, Tae-Wook Chung, Jing Chen
Publikováno v:
The Journal of biological chemistry. 289(38)
The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in regulation of glucose homoeostasis in mammalian cells. PDC flux depends on catalytic activity of the most important enzyme component pyruvate dehydrogenase (PDH). PDH kina
Autor:
Sean A. Beausoleil, Vicky Yang, Xiaoying Jia, Jon M. Kornhauser, Jeffrey C. Silva, Kimberly Lee, Jianmin Ren, Jing Zhou, Daniel Mulhern, Mike Aguiar, Hongbo Gu, Vidyasiri Vemulapalli, Mark T. Bedford, Michael J. Comb, Ailan Guo, Yi Wang
Publikováno v:
Molecular & Cellular Proteomics : MCP
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and si
Autor:
Jae Ho Seo, Moosa Mohammadi, Laura Mae P. Britton, Erwin G. Van Meir, Titus J. Boggon, Mike Aguiar, Changliang Shan, Hee-Bum Kang, Benjamin A. Garcia, Meghan Ann Tucker, Jing Chen, Stefan Kaluz, Sumin Kang, Manila Gaddh, Martha Arellano, Fadlo R. Khuri, Shannon Elf, Jianxin Xie, Narra S. Devi, Hanna Jean Khoury, Lonning Scott Michael, Ting-Lei Gu, Huaibin Chen, Sagar Lonial, Maša Alečković, Yibin Kang, Taro Hitosugi, Jun Fan
Publikováno v:
Molecular cell. 53(4)
Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cells. The current understanding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase (PDK), wher
Autor:
Anthony Possemato, Klarisa Rikova, Ben Hall, Jian Min Ren, Tyler Levy, Sean A. Beausoleil, Lonning Scott Michael, Mike Aguiar, Michael J. Comb, Kimberly Lee
Publikováno v:
Cancer Research. 76:LB-067
Lung cancer is the most common type of cancer in the U.S., with 5 yr. survival rates of 18% and 6% for non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC) patients, respectively. In spite of success with targeted therapies for
Autor:
Mark A. Behlke, Yerramilli V.B.K. Subrahmanyam, Etienne Gagnon, Maja M. Janas, Jonathan M. Shaffer, Carl D. Novina, Bingbing Wang, Mike Aguiar, Steven P. Gygi, Kai W. Wucherpfennig, Abigail S. Harris
Publikováno v:
RNA (New York, N.Y.). 18(11)
MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs