Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Mike A. Stashko"'
Autor:
James M. Trevillyan, Charles W. Hutchins, Thorsten Oost, Mike A. Stashko, Gang Liu, Tom Lubben, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Zhili Xin, Steve J. Ballaron, Philip J. Hajduk, Mike R Jirousek, Zhonghua Pei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1887-1890
—Wehavepreviouslyreportedanovelseriesofoxalyl-aryl-aminobenzoicacid-based,catalyticsite-directed,competitive,reversibleproteintyrosinephosphatase1B(PTP1B)inhibitors.Withreadilyaccesstokeyintermediates,weutilizedasolutionphaseparallelsynthesisapproa
Autor:
Bradley A. Zinker, Stephen W. Fesik, Bruce G. Szczepankiewicz, Charles W. Hutchins, Heng Liang, Cele Abad-Zapatero, David A. Janowick, Amanda K Mika, James M. Trevillyan, Mike A. Stashko, Zhonghua Pei, Steve J. Ballaron, Zhili Xin, Philip J. Hajduk, Michael R. Jirousek, Gang Liu, Tom Lubben
Publikováno v:
Journal of medicinal chemistry. 46(11)
Protein Tyrosine phosphatase 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling pathways. Using an NMR-based screening approach with 15N- and 13C-labeled PTP1B, we have identified 2,3-dimethylphenyloxalyla