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Akademický článek

Structural basis for type VI secretion effector recognition by a cognate immunity protein.

Autor: Mo Li, Isolde Le Trong, Mike A Carl, Eric T Larson, Seemay Chou, Justin A De Leon, Simon L Dove, Ronald E Stenkamp, Joseph D Mougous

Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002613 (2012)

The type VI secretion system (T6SS) has emerged as an important mediator of interbacterial interactions. A T6SS from Pseudomonas aeruginosa targets at least three effector proteins, type VI secretion exported 1-3 (Tse1-3), to recipient Gram-negative

Externí odkaz: https://doaj.org/article/d3ccada5995f4255a3a1c382a51dddd3

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Akademický článek

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.

Autor: Sandra Schwarz, T Eoin West, Frédéric Boyer, Wen-Chi Chiang, Mike A Carl, Rachel D Hood, Laurence Rohmer, Tim Tolker-Nielsen, Shawn J Skerrett, Joseph D Mougous

Publikováno v: PLoS Pathogens, Vol 6, Iss 8, p e1001068 (2010)

Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the five type VI secretion systems (T6SSs) of Burkholderia th

Externí odkaz: https://doaj.org/article/6b331782aa9c40a58562c3996ab1a559

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Akademický článek

Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections

Autor: Robert Thänert, Anna Thänert, Jocelyn Ou, Adam Bajinting, Carey-Ann D. Burnham, Holly J. Engelstad, Maria E. Tecos, I. Malick Ndao, Carla Hall-Moore, Colleen Rouggly-Nickless, Mike A. Carl, Deborah C. Rubin, Nicholas O. Davidson, Phillip I. Tarr, Barbara B. Warner, Gautam Dantas, Brad W. Warner

Publikováno v: Gut Microbes, Vol 13, Iss 1 (2021)

Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders of infancy, can result in a form of intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are a major challenge in pediatric SBS

Externí odkaz: https://doaj.org/article/34e2a30a876a42fbb17b0150d61db8e2

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Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections

Autor: Carla Hall-Moore, Maria E. Tecos, I. Malick Ndao, Brad W. Warner, Anna Thänert, Colleen Rouggly-Nickless, Holly J. Engelstad, Mike A. Carl, Robert Thänert, Jocelyn Ou, Adam Bajinting, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas, Nicholas O. Davidson, Deborah C. Rubin, Carey-Ann D. Burnham

Publikováno v: Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d556fa9439d24653705be1ca71fbddb6
http://europepmc.org/articles/PMC8284144

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Determinants of Initial Antibiotic Duration in Very Low Birth Weight Neonates

Autor: Alexandra C. Charron, Barbara B. Warner, Mike A. Carl, Christopher McPherson, Jason G. Newland

Publikováno v: Infectious Diseases and Therapy, Vol 8, Iss 2, Pp 209-217 (2019)
Infectious Diseases and Therapy

Introduction Very low birth weight (VLBW) neonates ( 5 days) increases an infant’s risk for necrotizing enterocolitis, late onset sepsis, colonization or infection with resistant organisms, and death. The aim of this study is to describe clinical a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73ef5dce58e21409be462a69f50ca35
http://link.springer.com/article/10.1007/s40121-019-0241-6

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A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

Autor: Rachel D. Hood, Wenzhuo Y. Wang, Rex R.S. Trinidad, Alexey J. Merz, Mike A. Carl, Joseph D. Mougous, FoSheng Hsu, David R. Goodlett, Tüzün Güvener, Sandra Schwarz, Pragya Singh, Rachael L. Plemel, Julie M. Silverman, Kevin G. Hicks, Brooks B. Ohlson, Mo Li

Publikováno v: Cell Host & Microbe. 7(1):25-37

SummaryThe functional spectrum of a secretion system is defined by its substrates. Here we analyzed the secretomes of Pseudomonas aeruginosa mutants altered in regulation of the Hcp Secretion Island-I-encoded type VI secretion system (H1-T6SS). We id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb46332436a3c30378991b2462267b08

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Escherichia coli DraE Adhesin-Associated Bacterial Internalization by Epithelial Cells Is Promoted Independently by Decay-Accelerating Factor and Carcinoembryonic Antigen-Related Cell Adhesion Molecule Binding and Does Not Require the DraD Invasin

Autor: Veronika Tchesnokova, Ann E. Stapleton, Nina Yazvenko, Steve L. Moseley, Mike A. Carl, Yuliya Yarova-Yarovaya, Natalia Korotkova

Publikováno v: Infection and Immunity. 76:3869-3880

The Dr family of Escherichia coli adhesins are virulence factors associated with diarrhea and urinary tract infections. Dr fimbriae are comprised of two subunits. DraE/AfaE represents the major structural, antigenic, and adhesive subunit, which recog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa994c1e6f68a7b08463196593b91b8
https://doi.org/10.1128/iai.00427-08

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Sepsis From the Gut: The Enteric Habitat of Bacteria That Cause Late-Onset Neonatal Bloodstream Infections

Autor: Erica Sodergren Weinstock, Phillip I. Tarr, James R. Johnson, Nurmohammad Shaikh, I. Malick Ndao, A. Cody Springman, Harold J. Stevens, George M. Weinstock, Sahar Abubucker, Yanjiao Zhou, Carey-Ann D. Burnham, Carla Hall-Moore, Samuel Julian, Makedonka Mitreva, Shannon D. Manning, Todd Wylie, Barbara B. Warner, Mike A. Carl, Brian D. Johnston

Background. Late-onset sepsis is a major problem in neonatology, but the habitat of the pathogens before bloodstream invasion occurs is not well established. Methods. We examined prospectively collected stools from premature infants with sepsis to fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119cfdd0e9bd7aa730e5fbc16d8f75d9
https://europepmc.org/articles/PMC3982840/

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A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach

Autor: Danielle M. Agnello, Mike A. Carl, Mitchell J. Brittnacher, Nhat Khai Bui, Joseph D. Mougous, Alistair B. Russell, Sandra Schwarz, Rachel D. Hood, Waldemar Vollmer, Pragya Singh, David R. Goodlett

Publikováno v: Cell Host & Microbe
Cell Host & Microbe; Vol 11

Sophisticated mechanisms are employed to facilitate information exchange between interfacing bacteria. A type VI secretion system (T6SS) of Pseudomonas aeruginosa was shown to deliver cell wall-targeting effectors to neighboring cells. However, the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9116ac5e29a4b346c0e6b9ce38b4442
https://pubmed.ncbi.nlm.nih.gov/22607806

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Structural basis for type VI secretion effector recognition by a cognate immunity protein

Autor: Simon L. Dove, Mo Li, Ronald E. Stenkamp, Eric T. Larson, Seemay Chou, Mike A. Carl, Joseph D. Mougous, Justin A. De Leon, Isolde Le Trong

Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002613 (2012)
PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c37e87d8b357ceb15a35311386be83
http://europepmc.org/articles/PMC3325213?pdf=render

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