Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mike A, Leonis"'
Autor:
Estella M. Alonso, Sean Maynor, Jacob Bleesing, Catherine A Chapin, Robert H. Squires, Alexander Miethke, Mike A. Leonis, Lin Fei
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Immune dysregulation contributes to the pathogenesis of pediatric acute liver failure (PALF). Our aim was to identify immune activation markers (IAMs) in PALF that are associated with a distinct clinical phenotype and outcome. AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d03e1a4ed5df915d0a191c45ea71864
https://doi.org/10.1002/hep.31271
https://doi.org/10.1002/hep.31271
Autor:
Lorena A. Ostilla, Portia A. Kreiger, Mike A. Leonis, Sarah A. Taylor, Katie Neighbors, Catherine A Chapin, Robert H. Squires, Simon Horslen, Hector Melin-Aldana, Estella M. Alonso, Joshua B. Wechsler, Thomas Burn, Edward M. Behrens, Kathleen M. Loomes
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 71:713-719
Objectives In many pediatric acute liver failure (PALF) cases, a diagnosis is not identified, and the etiology is indeterminate (IND-PALF). Our pilot study found dense CD8 T-cell infiltrates and increased T-cell clonality in liver specimens from IND-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518104f8f4c4ca34554d62789747f9e2
https://doi.org/10.1097/mpg.0000000000002893
https://doi.org/10.1097/mpg.0000000000002893
Autor:
Robert H. Squires, Derek Barclay, Estella M. Alonso, Yoram Vodovotz, Timothy R. Billiar, Ruben Zamora, Jinling Yin, Mike A. Leonis, Richard L. Simmons, Qi Mi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Acetaminophen (APAP) overdose (APAPo) is predominant in the NIH Pediatric Acute Liver Failure (PALF) Study. We assayed multiple inflammatory mediators in serial serum samples from 13 PALF survivors with APAPo + N-acetylcysteine (NAC, the frontline th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745f6e5bedd899f36b7fa7360075d8ec
http://link.springer.com/article/10.1038/s41598-019-42564-5
http://link.springer.com/article/10.1038/s41598-019-42564-5
Autor:
Michael R. Narkewicz, Simon Horslen, Regina M. Hardison, Benjamin L. Shneider, Norberto Rodriguez-Baez, Estella M. Alonso, Vicky L. Ng, Mike A. Leonis, Kathleen M. Loomes, David A. Rudnick, Philip Rosenthal, Rene Romero, Girish C. Subbarao, Ruosha Li, Steven H. Belle, Robert H. Squires, Kathryn Bukauskas, Madeline Schulte, Michelle Hite, Elizabeth B. Rand, David Piccoli, Deborah Kawchak, Christa Seidman, Saul Karpen, Liezl de la Cruz-Tracy, Vicky Ng, Kelsey Hunt, Ann Klipsch, Sarah Munson, Lisa Sorenson, Susan Kelly, Katie Neighbors, Shannon Fleck, John Bucuvalas, Tracie Horning, Norberto Rodriguez Baez, Shirley Montanye, Margaret Cowie, Simon P. Horslen, Karen Murray, Melissa Young, Heather Nielson, Jani Klein, Ross W. Shepherd, Kathy Harris, Saul J. Karpen, Alejandro De La Torre, Dominic Dell Olio, Deirdre Kelly, Carla Lloyd, Steven J. Lobritto, Sumerah Bakhsh, Maureen Jonas, Scott A. Elifoson, Roshan Raza, Kathleen B. Schwarz, Wikrom W. Karnsakul, Mary Kay Alford, Anil Dhawan, Emer Fitzpatrick, Nanda N. Kerkar, Brandy Haydel, Sreevidya Narayanappa, M. James Lopez, Victoria Shieck, Edward Doo, Averell H. Sherker
Background & Aims Many pediatric patients with acute liver failure (PALF) do not receive a specific diagnosis (such as herpes simplex virus or Wilson disease or fatty acid oxidation defects)—they are left with an indeterminate diagnosis and are mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1500bf22a47bd8d7caf4f65a791e0570
https://europepmc.org/articles/PMC6197895/
https://europepmc.org/articles/PMC6197895/
Autor:
Lisa G. Sorensen, Katie Neighbors, Regina M. Hardison, Kathleen M. Loomes, James W. Varni, Vicky L. Ng, Robert H. Squires, Estella M. Alonso, Kathryn Bukauskas, Madeline Schulte, Michael R. Narkewicz, Michelle Hite, Elizabeth B. Rand, David Piccoli, Deborah Kawchak, Christa Seidman, Rene Romero, Saul Karpen, Liezl de la Cruz-Tracy, Kelsey Hunt, Girish C. Subbarao, Ann Klipsch, Sarah Munson, Susan Kelly, Philip J. Rosenthal, Shannon Fleck, Mike A. Leonis, John Bucuvalas, Tracie Horning, Norberto Rodriguez Baez, Shirley Montanye, Margaret Cowie, Simon P. Horslen, Karen Murray, Melissa Young, Heather Nielson, Jani Klein, David A. Rudnick, Ross W. Shepherd, Kathy Harris, Saul J. Karpen, Alejandro De La Torre, Dominic Dell Olio, Deirdre Kelly, Carla Lloyd, Steven J. Lobritto, Sumerah Bakhsh, Maureen Jonas, Scott A. Elifoson, Roshan Raza, Kathleen B. Schwarz, Wikrom W. Karnsakul, Mary Kay Alford, Anil Dhawan, Emer Fitzpatrick, Nanda N. Kerkar, Brandy Haydel, Sreevidya Narayanappa, M. James Lopez, Victoria Shieck
Publikováno v:
The Journal of pediatrics. 196
To determine health-related quality of life (HRQoL) and neurocognitive impairment in survivors of pediatric acute liver failure (PALF).A longitudinal prospective study was conducted. At 6 and 12 months after PALF presentation, surveys of HRQoL were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26669d2a37e24b7cba3e1c0d748cb723
https://pubmed.ncbi.nlm.nih.gov/29551316
https://pubmed.ncbi.nlm.nih.gov/29551316
Autor:
James F. Daniel, Shikha S. Sundaram, Katryn N. Furuya, Grzegorz Telega, Jason Yap, Estella M. Alonso, Veena Venkat, Chris Sonnenday, Eberhard Lurz, Tamir Miloh, Binita M. Kamath, Linda S. Book, Claudia Quammie, Vicky L. Ng, Evelyn K. Hsu, Henry C. Lin, Michael J. Englesbe, Mike A. Leonis, Ryan Himes, Jerome Menendez, John C. Bucuvalas, Nitika A. Gupta, Rulan S. Parekh
Publikováno v:
The Journal of pediatrics. 194
To assess frailty, a measure of physiologic declines in multiple organ systems, in children with chronic liver disease using a novel pediatric frailty tool.We performed a prospective cross-sectional multicenter study at 17 liver transplantation (LT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e087a419c371b8c6723b77827e3a7dd0
https://pubmed.ncbi.nlm.nih.gov/29478492
https://pubmed.ncbi.nlm.nih.gov/29478492
Autor:
Sharon A. Miller, Mike A. Leonis, C. James McKnight, Frank M. van Bockxmeer, Amanda J. Hooper, John R. Burnett
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1841:1548-1554
Objective The microsomal triglyceride transfer protein (MTTP) plays a critical role in the formation of hepatic very low density lipoprotein. Abetalipoproteinemia (ABL) is a rare, naturally occurring extreme form of MTTP inhibition, which is characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2b9d7486c8c8d010e0bd00fb24a826
https://doi.org/10.1016/j.bbalip.2014.08.001
https://doi.org/10.1016/j.bbalip.2014.08.001
Publikováno v:
Pediatrics. 131:e740-e746
BACKGROUND: Acetaminophen (N-acetyl-p-aminophenol [APAP]) is a widely used medication that can cause hepatotoxicity. We examined characteristics and outcomes of children with chronic exposure (CE) to APAP in the multinational Pediatric Acute Liver Fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af33656cd040f5c4bffa127dd6d89cd8
https://doi.org/10.1542/peds.2011-3035
https://doi.org/10.1542/peds.2011-3035
Autor:
Vicky L. Ng, Steven H. Belle, Robert H. Squires, David A. Rudnick, Mike A. Leonis, Ruosha Li, Kathleen M. Loomes
OBJECTIVES Hepatic encephalopathy (HE) is challenging to identify in children with acute liver failure and was not a requirement for enrollment into the Pediatric Acute Liver Failure Study Group (PALFSG). The outcomes of PALFSG participants presentin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b8239ff867e9aaf1581107434cc61
https://europepmc.org/articles/PMC4992416/
https://europepmc.org/articles/PMC4992416/
Autor:
Mike A. Leonis, William F. Balistreri
Publikováno v:
Gastroenterology. 134:1741-1751
End-stage liver disease in children presents a challenging array of medical and psychosocial problems for the health care delivery team. Many of these problems are similar to those encountered by caregivers of adults with end-stage liver disease, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafaced818bfb73ad61414bf9f0a49e5
https://doi.org/10.1053/j.gastro.2008.02.029
https://doi.org/10.1053/j.gastro.2008.02.029