Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Mike A, Clark"'
Publikováno v:
Journal of Insurance Medicine. 47:107-113
Objective. – Further refine the independent value of NT-proBNP, accounting for the impact of other test results, in predicting all-cause mortality for individual life insurance applicants with and without heart disease. Method. – Using the Social
Publikováno v:
Eosinophils in Allergy and Inflammation ISBN: 9780367812591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98d7ddf940d63d82b1a02ceaed104a8
https://doi.org/10.1201/9780367812591-2
https://doi.org/10.1201/9780367812591-2
Autor:
Ilene D. Kurzman, Douglas H. Thamm, David M. Vail, Daniel L. Gustafson, Mike A. Clark, E. J. Ehrhart, Susan L. Kraft
Publikováno v:
Clinical Cancer Research. 16:1498-1508
Purpose: Tumor necrosis factor-α (TNF) is a cytokine with potent antitumor activity; however, toxicity and short half-life have limited its utility. Polyethylene glycol (PEG) conjugation of biotherapeutics can decrease immunogenicity while improving
Autor:
John S. Bomalaski, C. Mark Ensor, Maurizio Montella, Gerardo Beneduce, Guglielmo Nasti, Fabrizio Scordino, Antonio Pio Orlando, Mike A. Clark, F. Cremona, Raffaele Orlando, Giuseppe Castello, Frederick W. Holtzberg, Francesco Izzo, Brent E. Korba, Steven A. Curley
Publikováno v:
Journal of Gastroenterology and Hepatology. 22:86-91
Background: The arginine-degrading enzyme, arginine deiminase conjugated to polyethylene glycol (ADI-SS PEG 20 000 mw), reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with chronic
Autor:
Mike A. Clark, John S. Bomalaski
Publikováno v:
Current Rheumatology Reports. 6:240-247
Although allopurinol has been available for approximately 50 years, hyperuricemia and its sequelae are not only prevalent, but the incidence and costs associated with this disorder continue to increase. However, several new therapies have been develo
Autor:
Giuseppe Castello, Frederick W. Holtsberg, Paolo Marra, John S. Bomalaski, Steven A. Curley, Chaan S. Ng, Francesco Izzo, Vincenzo De Rosa, Paolo Vallone, Gerardo Beneduce, Mike A. Clark, C. Mark Ensor, Franco Cremona
Publikováno v:
Journal of Clinical Oncology. 22:1815-1822
Purpose Recently, we reported that a large number of human hepatocellular cancer (HCC) cell lines were auxotrophic for arginine. Here we report the results obtained with the amino acid–degrading enzyme arginine deiminase (ADI) conjugated to polyeth
Autor:
Mike A. Clark, Frederick W. Holtsberg, John S. Bomalaski, Victor G. Prieto, C. Mark Ensor, Brian J. Dillon, Steven A. Curley
Publikováno v:
Cancer. 100:826-833
BACKGROUND Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine. This pathway allowed cells to synthesize arginine from citrulline, making this amino acid nonessential for the growth of most mammalian cell
Publikováno v:
Biochemical Journal. 363:581-587
Septic shock is mediated in part by nitric oxide (NO) and tumour necrosis factor α (TNFα). NO is synthesized primarily from extracellular arginine. We tested the ability of an arginine-degrading enzyme to inhibit NO production in mice and to protec
Autor:
Mike A. Clark, John S. Bomalaski, Frederick W. Holtsberg, Charles Mark Ensor, Marion R. Steiner
Publikováno v:
Journal of Controlled Release. 80:259-271
Some tumors, such as melanomas and hepatocellular carcinomas, have a unique nutritional requirement for arginine. Thus, enzymatic degradation of extracellular arginine is one possible means for inhibiting these tumors. Arginine deiminase is an argini
Autor:
Andashok K. Chopra, William D. Dickey, Mike A. Clark, John S. Bomalaski, Xin-Jing Xu, Gary R. Klimpel, Shamsher S. Saini, Johnny W. Peterson
Publikováno v:
Infection and Immunity. 64:2137-2143
The mechanism of cholera toxin (CT)-stimulated arachidonate metabolism was evaluated. CT caused rapid in vitro synthesis of prostaglandin E2 (PGE2) in murine smooth muscle-like cells (BC3H1), reaching maximal levels within 3 to 4 min. In comparison,