Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Mike Partridge"'
Autor:
Marcin Paczkowski, Warren W. Kretzschmar, Bostjan Markelc, Stanley K. Liu, Leoni A. Kunz-Schughart, Adrian L. Harris, Mike Partridge, Helen M. Byrne, Pavitra Kannan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic i
Externí odkaz:
https://doaj.org/article/a08140e263164d63ab72ee83c273ffdf
Autor:
Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge, Tim Maughan
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Background There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant chemoradiotherapy (CRT
Externí odkaz:
https://doaj.org/article/ce03070ed2574705952db13efca95313
Autor:
Veerle Kersemans, Ricky A. Sharma, Mike Partridge, Ruth J. Muschel, Adrian L. Harris, Tim Maughan, Julia A. Schnabel, Sean Smart, Stuart Gilchrist, Paul Kinchesh, Bosjtan Markelc, Jakob Kaeppler, Bartlomiej W. Papiez, Benjamin Irving, Nigar Syed, Philip D. Allen, Russell Bates, Daniel Warren, Helen Winter, Warren W. Kretzschmar, Pavitra Kannan
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8bf5abfae121c63556b55f9b40579c
https://doi.org/10.1158/1078-0432.c.6527586
https://doi.org/10.1158/1078-0432.c.6527586
Autor:
Veerle Kersemans, Ricky A. Sharma, Mike Partridge, Ruth J. Muschel, Adrian L. Harris, Tim Maughan, Julia A. Schnabel, Sean Smart, Stuart Gilchrist, Paul Kinchesh, Bosjtan Markelc, Jakob Kaeppler, Bartlomiej W. Papiez, Benjamin Irving, Nigar Syed, Philip D. Allen, Russell Bates, Daniel Warren, Helen Winter, Warren W. Kretzschmar, Pavitra Kannan
Supplementary methods and data. Supplementary Table 1. Equations of chosen models fit using ordinary least squares regression with the best Bayesian Information Criterion for iAUC90, Ktrans, and BATfrac in untreated preclinical tumors (cohort 1). Goo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57976c059b7a53d0abb5e6c056d2f328
https://doi.org/10.1158/1078-0432.22470495.v1
https://doi.org/10.1158/1078-0432.22470495.v1
Autor:
David Robert Grimes, Pavitra Kannan, Alan McIntyre, Anthony Kavanagh, Abul Siddiky, Simon Wigfield, Adrian Harris, Mike Partridge
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153692 (2016)
The oxygen status of a tumor has significant clinical implications for treatment prognosis, with well-oxygenated subvolumes responding markedly better to radiotherapy than poorly supplied regions. Oxygen is essential for tumor growth, yet estimation
Externí odkaz:
https://doaj.org/article/81e85474e86b4d5491b90aadd6f5de28
Autor:
Veerle Kersemans, Pavitra Kannan, John S Beech, Russell Bates, Benjamin Irving, Stuart Gilchrist, Philip D Allen, James Thompson, Paul Kinchesh, Christophe Casteleyn, Julia Schnabel, Mike Partridge, Ruth J Muschel, Sean C Smart
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128537 (2015)
Preclinical in vivo CT is commonly used to visualise vessels at a macroscopic scale. However, it is prone to many artefacts which can degrade the quality of CT images significantly. Although some artefacts can be partially corrected for during image
Externí odkaz:
https://doaj.org/article/ed6f36bc39f44202a4c525d14f8c532a
Autor:
Marco Borri, Maria A Schmidt, Ceri Powell, Dow-Mu Koh, Angela M Riddell, Mike Partridge, Shreerang A Bhide, Christopher M Nutting, Kevin J Harrington, Katie L Newbold, Martin O Leach
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138545 (2015)
PURPOSE:To describe a methodology, based on cluster analysis, to partition multi-parametric functional imaging data into groups (or clusters) of similar functional characteristics, with the aim of characterizing functional heterogeneity within head a
Externí odkaz:
https://doaj.org/article/0188356f33854b9cb081b39028b4680d
Publikováno v:
Radiotherapy and Oncology. 138:38-44
The limited radiation tolerance of the small-bowel causes toxicity for patients receiving conventionally-fractionated radiotherapy for rectal cancer. Safe radiotherapy dose-escalation will require a better understanding of such toxicity. We conducted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084bff81d1ef177c445f7176ee31666c
https://doi.org/10.1016/j.radonc.2019.05.001
https://doi.org/10.1016/j.radonc.2019.05.001
Publikováno v:
Royal Society Open Science, Vol 1, Iss 1 (2014)
Oxygen levels in cancerous tissue can have a significant effect on treatment response: hypoxic tissue is both more radioresistant and more chemoresistant than well-oxygenated tissue. While recent advances in medical imaging have facilitated real-time
Externí odkaz:
https://doaj.org/article/526c0a2de5a2437dab9001a1d0ffe403
Autor:
Pavitra Kannan, Stanley K. Liu, Adrian L. Harris, Marcin Paczkowski, Warren W. Kretzschmar, Bostjan Markelc, Helen M. Byrne, Leoni A. Kunz-Schughart, Mike Partridge
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Intratumoural heterogeneity (ITH) contributes to local recurrence following radiotherapy in prostate cancer. Recent studies also show that ecological interactions between heterogeneous tumour cell populations can lead to resistance in chemotherapy. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe6936c0d09bc9b09ef19f6a2ab80c8
https://doi.org/10.1038/s42003-020-01529-5
https://doi.org/10.1038/s42003-020-01529-5