Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Mike, Stembridge"'
Autor:
Jack S. Talbot, Dean R. Perkins, Christine M. Tallon, Tony G. Dawkins, Andrew J. M. Douglas, Ryan Beckerleg, Andrew Crofts, Melissa E. Wright, Saajan Davies, Jessica J. Steventon, Kevin Murphy, Rachel N. Lord, Christopher J. A. Pugh, Jon L. Oliver, Rhodri S. Lloyd, Philip N. Ainslie, Ali M. McManus, Mike Stembridge
Publikováno v:
Experimental Physiology, Vol 108, Iss 12, Pp 1500-1515 (2023)
Abstract Global cerebral blood flow (gCBF) and cerebrovascular reactivity to hypercapnia (CVRCO2) are modulated by gonadal hormone activity, while insulin‐like growth factor 1 facilitates exercise‐mediated cerebral angiogenesis in adults. Whether
Externí odkaz:
https://doaj.org/article/20b61a3e79984408bcdf31f2b7030741
Autor:
Christine M. Tallon, Jack S. Talbot, Kurt J. Smith, Nia Lewis, Daniela Nowak‐Flück, Mike Stembridge, Philip Ainslie, Ali M. McManus
Publikováno v:
Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)
Abstract Intracranial blood velocity reactivity to a steady‐state hypercapnic stimulus has been shown to be similar in children and adults, but the onset response to hypercapnia is slower in the child. Given the vasodilatory effect of hypercapnia o
Externí odkaz:
https://doaj.org/article/7ffc215abe9248698e328aa7c1bbb78c
Autor:
Lydia L. Simpson, Alexander B. Hansen, Gilbert Moralez, Sachin B. Amin, Florian Hofstaetter, Christopher Gasho, Mike Stembridge, Tony G. Dawkins, Michael M. Tymko, Philip N. Ainslie, Justin S. Lawley, Christopher M. Hearon
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R457-R469
Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic vasoconstriction at sea level (SL), has not been examined at HA. In nine male lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9b62085750b6f64476bab0732909f3
https://doi.org/10.1152/ajpregu.00230.2022
https://doi.org/10.1152/ajpregu.00230.2022
Autor:
Lindsey F. Berthelsen, Andrew J.M. Douglas, Tony G. Dawkins, Bryony A. Curry, Daniel Philips, Abbas Zaidi, Zaheer Yousef, Mike Stembridge, Craig D. Steinback
Publikováno v:
Applied Physiology, Nutrition, and Metabolism. 48:270-282
Apnea (breath-holding) elicits co-activation of sympathetic and parasympathetic nervous systems, affecting cardiac control. In situations of autonomic co-activation (e.g., cold water immersion), cardiac arrhythmias are observed during apnea. Chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d55bea2d06b7587346672e23e345cd15
https://doi.org/10.1139/apnm-2022-0340
https://doi.org/10.1139/apnm-2022-0340
Autor:
Stephen A. Busch, Sean van Diepen, Andrew R. Steele, Victoria L. Meah, Lydia L. Simpson, Rómulo J. Figueroa-Mujíca, Gustavo Vizcardo-Galindo, Francisco C. Villafuerte, Michael M. Tymko, Philip N. Ainslie, Jonathan P. Moore, Mike Stembridge, Craig D. Steinback
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Background: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e., Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent arrhythmogenesis
Externí odkaz:
https://doaj.org/article/5d0035d846814f06a475b9dc09e445d2
Autor:
Jay MJR Carr, Philip N Ainslie, David B MacLeod, Joshua C Tremblay, Daniela Nowak-Flück, Connor A Howe, Mike Stembridge, Alexander Patrician, Geoff B Coombs, Benjamin S Stacey, Damian M Bailey, Daniel J Green, Ryan L Hoiland
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:99-114
This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e240a0f8e294cee21d2691e7c6f9b6b
https://doi.org/10.1177/0271678x221119442
https://doi.org/10.1177/0271678x221119442
Publikováno v:
The Journal of Physiology. 600:4089-4104
Over the last 100 years, high-altitude researchers have amassed a comprehensive understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia. When lowlanders are exposed to hypoxia, the drop in arterial oxygen content demand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9e64e98ca4b0a451a9b814101f546c
https://doi.org/10.1113/jp281724
https://doi.org/10.1113/jp281724
Autor:
Austin J. White, Lindsey M. Boulet, Brooke M. Shafer, Tyler D. Vermeulen, Taylor L. Atwater, Mike Stembridge, Philip N. Ainslie, Richard J. A. Wilson, Trevor A. Day, Glen E. Foster
Publikováno v:
Journal of Applied Physiology. 132:1327-1337
Myocardial oxygen delivery is primarily regulated through changes in vascular tone to match increased metabolic demands. In males, activation of the muscle metaboreflex during acute isocapnic hypoxia results in paradoxical coronary vasoconstriction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f76ab4ae124653e17de118a9247875
https://doi.org/10.1152/japplphysiol.00018.2022
https://doi.org/10.1152/japplphysiol.00018.2022
Autor:
Gustavo Vizcardo-Galindo, Ryan L. Hoiland, Christopher Gasho, Francisco C. Villafuerte, Kaitlyn Tymko, Courtney Tymko, James D. Anholm, John D. Akins, Philip N. Ainslie, Michael M. Tymko, Travis D. Gibbons, Rachel Stone, Geoff B. Coombs, Mike Stembridge, Connor A. Howe, Damian M. Bailey, Joshua C. Tremblay, Tony G. Dawkins, Alexander Patrician, Benjamin S. Stacey, Rómulo Figueroa-Mujíca
Publikováno v:
Chest. 161:1022-1035
BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness (CMS) is resistant to iron adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b782c7ad08d714e67219d696a015ac2c
https://doi.org/10.1016/j.chest.2021.08.075
https://doi.org/10.1016/j.chest.2021.08.075
Autor:
Gustavo Vizcardo-Galindo, Tony G. Dawkins, Christopher Gasho, Victoria L Meah, Michael M. Tymko, Andrew R. Steele, Alexandra M. Williams, Craig D. Steinback, Francisco C. Villafuerte, Lydia L. Simpson, Philip N. Ainslie, Mike Stembridge, Jonathan P. Moore, Rómulo Figueroa-Mujíca
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 321:R504-R512
The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and is associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear if indigenous highlanders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd84e1bc03d0d70e6acc655e9898cfe
https://doi.org/10.1152/ajpregu.00102.2021
https://doi.org/10.1152/ajpregu.00102.2021