Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Mike, Heilemann"'
Autor:
Yunqing Li, Serena M. Arghittu, Marina S. Dietz, Gabriel J. Hella, Daniel Haße, Davide M. Ferraris, Petra Freund, Hans-Dieter Barth, Luisa Iamele, Hugo de Jonge, Hartmut H. Niemann, Roberto Covino, Mike Heilemann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Embedding of cell-surface receptors into a membrane defines their dynamics but also complicates experimental characterization of their signaling complexes. The hepatocyte growth factor receptor MET is a receptor tyrosine kinase involved in c
Externí odkaz:
https://doaj.org/article/98dfe12d836b4598a39f3d730b372ba1
Autor:
Alexandra N. Birtasu, Utz H. Ermel, Johanna V. Rahm, Anja Seybert, Benjamin Flottmann, Mike Heilemann, Florian Grahammer, Achilleas S. Frangakis
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100114- (2024)
The functioning of vertebrate life relies on renal filtration of surplus fluid and elimination of low-molecular-weight waste products, while keeping serum proteins in the blood. In disease, however, there is leak of serum proteins and tracing them to
Externí odkaz:
https://doaj.org/article/6718c41a6286459188f41b765da606f8
Autor:
Rayene Berkane, Hung Ho-Xuan, Marius Glogger, Pablo Sanz-Martinez, Lorène Brunello, Tristan Glaesner, Santosh Kumar Kuncha, Katharina Holzhüter, Sara Cano-Franco, Viviana Buonomo, Paloma Cabrerizo-Poveda, Ashwin Balakrishnan, Georg Tascher, Koraljka Husnjak, Thomas Juretschke, Mohit Misra, Alexis González, Volker Dötsch, Paolo Grumati, Mike Heilemann, Alexandra Stolz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that members of the FAM134 f
Externí odkaz:
https://doaj.org/article/e10140371dcc4b28b702bcd423ea45dd
Autor:
Soohyen Jang, Kaarjel K. Narayanasamy, Johanna V. Rahm, Alon Saguy, Julian Kompa, Marina S. Dietz, Kai Johnsson, Yoav Shechtman, Mike Heilemann
Publikováno v:
Biophysical Reports, Vol 3, Iss 3, Pp 100123- (2023)
Single-molecule localization microscopy achieves nanometer spatial resolution by localizing single fluorophores separated in space and time. A major challenge of single-molecule localization microscopy is the long acquisition time, leading to low thr
Externí odkaz:
https://doaj.org/article/2badc65737f14fbdaa7d100fb9143d9e
Autor:
Pietro Verzelli, Andreas Nold, Chao Sun, Mike Heilemann, Erin M. Schuman, Tatjana Tchumatchenko
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Single-molecule localization microscopy resolves objects below the diffraction limit of light via sparse, stochastic detection of target molecules. Single molecules appear as clustered detection events after image reconstruction. However, id
Externí odkaz:
https://doaj.org/article/4cf03207d65f47e09771456e5f3bb423
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
DNA-PAINT image acquisition is limited by speed. Here the authors use the neural network DeepSTORM to predict fluorophore positions from high emitter density DNA-PAINT data in order to achieve image acquisition in one minute; they demonstrate multi-c
Externí odkaz:
https://doaj.org/article/c9cb7bec6ca74be18b19fa366aec6b5b
Autor:
Christoph Spahn, Estibaliz Gómez-de-Mariscal, Romain F. Laine, Pedro M. Pereira, Lucas von Chamier, Mia Conduit, Mariana G. Pinho, Guillaume Jacquemet, Séamus Holden, Mike Heilemann, Ricardo Henriques
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
DeepBacs guides users without expertise in machine learning methods to leverage state-of-the-art artificial neural networks to analyse bacterial microscopy images.
Externí odkaz:
https://doaj.org/article/19fbd4827d134373b89f42b5d1bcdbc7
Autor:
Shivam Yadav, Martin Centola, Mathilda Glaesmann, Denys Pogoryelov, Roman Ladig, Mike Heilemann, L. C. Rai, Özkan Yildiz, Enrico Schleiff
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cyclophilins are proteins found in many organisms, where they can play roles as chaperones, in signal transduction, or other functions. Here, Yadav et al. show that a cyanobacterial cyclophilin is involved in stress responses and in assembly of photo
Externí odkaz:
https://doaj.org/article/aeb1a1382d184d9496b491da6eb13521
Autor:
Vanessa de Jesus, Nusrat S. Qureshi, Sven Warhaut, Jasleen K. Bains, Marina S. Dietz, Mike Heilemann, Harald Schwalbe, Boris Fürtig
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient
Externí odkaz:
https://doaj.org/article/2f9168db64244081a1ad083419291a8b
Autor:
Lucas von Chamier, Romain F. Laine, Johanna Jukkala, Christoph Spahn, Daniel Krentzel, Elias Nehme, Martina Lerche, Sara Hernández-Pérez, Pieta K. Mattila, Eleni Karinou, Séamus Holden, Ahmet Can Solak, Alexander Krull, Tim-Oliver Buchholz, Martin L. Jones, Loïc A. Royer, Christophe Leterrier, Yoav Shechtman, Florian Jug, Mike Heilemann, Guillaume Jacquemet, Ricardo Henriques
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Deep learning methods show great promise for the analysis of microscopy images but there is currently an accessibility barrier to many users. Here the authors report a convenient entry-level deep learning platform that can be used at no cost: ZeroCos
Externí odkaz:
https://doaj.org/article/71c9afaf6b9849e787693c838589c312