Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mikako Hirohama"'
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
IntroductionThe influenza virus genome consists of single-stranded RNAs and forms viral ribonucleoprotein (RNP) complexes. After viral genome replication in the nucleus, the viral RNP interacts with viral protein M1. The M1-viral RNP complex is expor
Externí odkaz:
https://doaj.org/article/e7a687dafaea4fbeb7706bc544e2ed7e
Autor:
Takeshi Sekiya, Yukino Ogura, Hirayasu Kai, Atsushi Kawaguchi, Shino Okawa, Mikako Hirohama, Takahiro Kuroki, Wataru Morii, Akira Hara, Yuji Hiramatsu, Shigemi Hitomi, Yasushi Kawakami, Yoshihiro Arakawa, Kazushi Maruo, Shigeru Chiba, Hiromichi Suzuki, Hiroshi Kojima, Hirokazu Tachikawa, Kunihiro Yamagata
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the TMPRSS2 gene, a missense variant common in East Asian
Externí odkaz:
https://doaj.org/article/c1b2e9b20dd745868ec02620a18a0c18
Autor:
Takahiro Kuroki, Sangjoon Lee, Mikako Hirohama, Tomohiro Taku, Michiko Kumakura, Takahiro Haruyama, Kyosuke Nagata, Atsushi Kawaguchi
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity
Externí odkaz:
https://doaj.org/article/1f99bd44c57043caa8dc737788e87a3c
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005284 (2015)
Influenza virus particles are assembled at the plasma membrane in concert with incorporation of the virus genome, but the details of its spatio-temporal regulation are not understood. Here we showed that influenza virus infection induces the assembly
Externí odkaz:
https://doaj.org/article/f09ed432587c427e88a1d0b1dcf417a4
Autor:
Yuta Funai, Christa E. Müller, Atsuhiko Taniguchi, Sho Konno, Yoshiyuki Shirasaka, Mikako Hirohama, Wataru Kamitani, Ikumi Tamai, Kiyotaka Kobayashi, Yoshio Hayashi, Thanigaimalai Pillaiyar, Koh Takeuchi, Laura Schäkel, Miki Senda, Akihiro Taguchi, Toshiya Senda, Kyousuke Sakata, Michael Gütschow, Yuta Seki, Atsushi Kawaguchi, Masaki Kojima
Publikováno v:
Journal of Medicinal Chemistry
The novel coronavirus, SARS-CoV-2, has been identified as the causative agent for the current coronavirus disease (COVID-19) pandemic. 3CL protease (3CLpro) plays a pivotal role in the processing of viral polyproteins. We report peptidomimetic compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b4fabeada62fef3607d023a9fad575
https://pubmed.ncbi.nlm.nih.gov/34313428
https://pubmed.ncbi.nlm.nih.gov/34313428
Autor:
Akio Yamashita, Masaru Takeshita, Mikako Hirohama, Kensaku Murano, Haruhiko Siomi, Atsushi Kawaguchi, Takeshi Sekiya, Youjia Guo
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has developed into a global pandemic since its first outbreak in the winter of 2019. An extensive investigation of SARS-CoV-2 is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2374831279b8aee5673390dbf03a8b3
https://doi.org/10.1101/2020.10.01.323220
https://doi.org/10.1101/2020.10.01.323220
Autor:
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schäkel, Kyousuke Sakata, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Gütschow, Michael, Müller, Christa E., Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani
Publikováno v:
Journal of Medicinal Chemistry; 2/24/2022, Vol. 65 Issue 4, p2926-2939, 14p
Autor:
SangJoon Lee, Atsushi Kawaguchi, Philipp P. Petric, Peter Staeheli, Akari Ishitsuka, Yuji Fujiyasu, Mikako Hirohama, Masayuki Noguchi, Martin Schwemmle, Kyosuke Nagata
Publikováno v:
Science Immunology. 4
The respiratory epithelium is exposed to the environment and initiates inflammatory responses to exclude pathogens. Influenza A virus (IAV) infection triggers inflammatory responses in the respiratory mucosa, but the mechanisms of inflammasome activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed437a0436b0f9b8c0cc32bff48e74e
https://doi.org/10.1126/sciimmunol.aau4643
https://doi.org/10.1126/sciimmunol.aau4643
Autor:
Yasuhiro Igarashi, Mohammad Tariq, Isao Fukuda, Hisato Saitoh, Minoru Yoshida, Mikako Hirohama, Akihiro Ito
Publikováno v:
The Journal of Antibiotics. 69:776-779
Conjugation of small ubiquitin-related modifier (SUMO) to target proteins (SUMOylation) is a posttranslational modification that regulates a wide range of biological processes, including transcription, intracellular transport, DNA repair, DNA replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a22720210b317ab4139cdbb7132c05
https://doi.org/10.1038/ja.2016.23
https://doi.org/10.1038/ja.2016.23
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1218-1223
Sumoylation involves the enzymatic conjugation of small ubiquitin-like modifier (SUMO) protein to their substrate proteins. Sumoylation is not only crucial for maintaining normal cellular physiology but also implicated in the development of several d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b752ca1a3b34229314dde087ecf77c4
https://doi.org/10.1016/j.bmcl.2016.01.030
https://doi.org/10.1016/j.bmcl.2016.01.030