Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mikako Degawa-Yamauchi"'
Autor:
Keith L. March, Lauren N. Bell, Helmut O. Steinberg, Jennifer L. Ward, Rose Marie Jones, Sudha S. Shankar, Brenda Cacucci, Carol Sheridan, Kevin M. Sheridan, Jason E. Bovenkerk, Robert V. Considine, Mikako Degawa-Yamauchi, Christine E. Gupta
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 291:E843-E848
Serum HGF is elevated in obese individuals. This study examined the contribution of excess adipose tissue to increased circulating HGF levels in obesity. Serum HGF was measured by ELISA before and after weight loss due to bariatric surgery or a 24-h
Autor:
Barbora, Vozarova de Courten, Mikako, Degawa-Yamauchi, Robert V, Considine, P Antonio, Tataranni, Barbora, Volarova de Courten
Publikováno v:
Diabetes. 53:1279-1284
Resistin is an adipokine with putative prodiabetogenic properties. Like other hormones secreted by adipose tissue, resistin is being investigated as a possible etiologic link between excessive adiposity and insulin resistance. Although there is growi
Autor:
Naruhiro Fujita, Katuya Ohshima, Yoshihiko Yamaguchi, Hironori Yamasaki, Ryoko Takahashi, Atsushi Kita, Shigeo Uotani, Mikako Degawa-Yamauchi, Hironaga Kuwahara, Hiroyuki Sakamaki, Takahiro Abe, Katsumi Eguchi
Publikováno v:
Molecular and Cellular Endocrinology. 205:115-120
Leptin, the 16 kDa protein product of the ob gene, is secreted by adipocytes. The long form leptin receptor (ObRb) is expressed at high levels in the hypothalamus, and regulates appetite and energy expenditure. The fact that serum concentration of le
Autor:
Shigeo Uotani, Hironori Yamasaki, Hirofumi Takino, Naruhiro Fujita, Kenichi Yamakawa, Takahiro Abe, Yoshihiko Yamaguchi, Masako Ozaki, Eiji Kawasaki, Hironaga Kuwahara, K Eguchi, Yasunori Sera, Mikako Degawa-Yamauchi
Publikováno v:
Acta Diabetologica. 39:221-227
To investigate the mechanism of severe impairment of insulin action in type B insulin resistance, we extracted IgG from the serum of a patient with type B insulin resistance (B-IgG) and analyzed the inhibiting effect of B-IgG not only on insulin sign
Autor:
Haruko Miyazoe, Eiji Kawasaki, Hironori Yamasaki, Kenichi Yamakawa, Takahiro Abe, Hirofumi Takino, Yoshihiko Yamaguchi, Katsumi Eguchi, Shigeo Uotani, Masako Ozaki, Naruhiro Fujita, Yasunori Sera, Mikako-Degawa Yamauchi
Publikováno v:
Endocrine Research. 27:63-74
To investigate the regulational interaction of hepatocyte nuclear factor-1alpha (HNF-1alpha) and insulin promoter factor 1 (IPF1) on insulin gene expression, either or both of the expression vectors carrying each transcription factor were transiently
Autor:
Tomoko Tsuchiya, Akira Yamauchi, Mikako Degawa-Yamauchi, Futoshi Kuribayashi, Shiro Kanegasaki
Publikováno v:
Journal of immunological methods. 404
To compare the responses of individual neutrophils to chemoattractants, migration pathway data were obtained using TAXIScan, an optically accessible/horizontal apparatus in which a concentration gradient is established reproducibly for a given stimul
Autor:
Yoshihiro Ogawa, Kazuki Yasuda, Ayaka Ito, Motohiro Takeya, Yuko Kobayashi, Yasutomi Kamei, Takayoshi Suganami, Shiro Kanegasaki, Miyako Tanaka, William A. Kuziel, Nao Nitta, Ryuji Kouyama, Mikako Degawa-Yamauchi, Yukio Hirata, Akira Yamauchi
Publikováno v:
The Journal of biological chemistry. 283(51)
The MCP-1 (monocyte chemoattractant protein-1)/CCR2 (CC motif chemokine receptor-2) pathway may play a role in macrophage infiltration into obese adipose tissue. Here we investigated the role of CCR2 in the recruitment of bone marrow-derived macropha
Autor:
Ryoko Ishida-Takahashi, Naruhiro Fujita, Tetsuya Fukushima, Mikako Degawa-Yamauchi, Takahiro Abe, Yoshihiko Yamaguchi, Katsumi Eguchi, Hironori Yamasaki, Hiroyuki Sakamaki, Shigeo Uotani
Publikováno v:
The Journal of biological chemistry. 279(19)
Elevated secretion of glucocorticoids (GCs) or hypersensitivity to GCs has a permissive effect on the development of obesity and leads to abnormalities of body fat distribution. Recent studies demonstrated GCs act as antagonists of leptin in rodents.
Autor:
Kimberly A Kerr, Robert V. Considine, Qihong Zhu, RoseMarie Jones, William R. Watson, Beth E. Juliar, Jason E. Bovenkerk, Mikako Degawa-Yamauchi
Publikováno v:
The Journal of clinical endocrinology and metabolism. 88(11)
The role of resistin in obesity and insulin resistance in humans is controversial. Therefore, resistin protein was quantitated by ELISA in serum of 27 lean [13 women/14 men, body mass index (BMI) 21.7 ± 0.4 kg/m2, age 33 ± 2 yr] and 50 obese (37 wo
Autor:
Robert V. Considine, William R. Watson, Beth E. Juliar, Jason E. Bovenkerk, Mikako Degawa-Yamauchi, RoseMarie Jones, Kimberly A Kerr
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:1977-1978