Výsledky vyhledávání - "Mikaela Therrien"

Insufficient developmental excitatory neuronal activity fails to foster establishment of normal levels of inhibitory neuronal activity

Autor: Mary Guaraldi, Mikaela Therrien, Edward F. Boumil, Sangmook Lee, Thomas B. Shea, Rishel Vohnoutka

Publikováno v: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 55

The nervous system is composed of excitatory and inhibitory neurons. One major class of inhibitory neurons release the neurotransmitter γ-Aminobutyric acid (GABA). GABAergic inhibitory activity maintains the balance that is disrupted in conditions s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c10d9db13e9d32bc8edc7b9fefb221
https://pubmed.ncbi.nlm.nih.gov/27686511

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Additive Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Oligomerized Amyloid-β and Airborne Nanoparticles Generated during Photocopying

Autor: Ikjot Singh Sohal, Thomas B. Shea, Sangmook Lee, Dhimiter Bello, Anoop K. Pal, Mikaela Therrien

Publikováno v: Journal of Alzheimer's disease : JAD. 47(1)

Photocopying in offices and printing centers releases nanoparticles that can reach the brain following inhalation. We examined whether subcytotoxic levels of airborne photocopy-emitted nanoparticles could potentiate perturbation of synaptic signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387b3f4554d82e618efc919d834ed705
https://pubmed.ncbi.nlm.nih.gov/26402753

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Synaptic signal streams generated by ex vivo neuronal networks contain non-random, complex patterns

Autor: Christina Courtright, Holly A. Yanco, Sangmook Lee, Mary Guaraldi, Jill M. Zemianek, Ben Y. Maron, Abraham Shultz, Thomas B. Shea, Anh Vo, Mikaela Therrien

Publikováno v: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 38

Cultured embryonic neurons develop functional networks that transmit synaptic signals over multiple sequentially connected neurons as revealed by multi-electrode arrays (MEAs) embedded within the culture dish. Signal streams of ex vivo networks conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade2e09c6a91597aca02d880322ee4cb
https://pubmed.ncbi.nlm.nih.gov/25172170

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