Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mikaela Laine"'
Autor:
Maija-Kreetta Koskinen, Mikaela Laine, Ali Abdollahzadeh, Adrien Gigliotta, Giulia Mazzini, Sarah Journée, Varpu Alenius, Kalevi Trontti, Jussi Tohka, Petri Hyytiä, Alejandra Sierra, Iiris Hovatta
Publikováno v:
Neuropsychopharmacology.
Differential expression of myelin-related genes and changes in myelin thickness have been demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To determine whether and how stress affects structural remodeling o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788efee646b65ba66fefd44d6bfcc541
https://doi.org/10.1038/s41386-023-01568-6
https://doi.org/10.1038/s41386-023-01568-6
Autor:
Mikaela Laine
Publikováno v:
University of Helsinki
Psychiatric disorders are very common, with anxiety disorders being the most prevalent (16 % lifetime prevalence). While moderately heritable, their incidence is also strongly influenced by environmental risk factors, chiefly psychosocial stress. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f276f6c00d2b4dc339bd51135aaf1050
http://hdl.handle.net/10138/322635
http://hdl.handle.net/10138/322635
Autor:
Celia Luchena, Catarina Barros, Tiziano Balzano, Sebastiano Curreli, Mette Lassen, Ole Kiehn, Carmelo Bellardita, Mikaela Laine, Iiris Hovatta, Verena Untiet, Dario Greco, Lynn Nazareth, Juan Martinez, Jose Antonio Fernandez Albarral, Susanne Michels, Ana Rita Vaz, Eija Jokitalo, Anchel González-Barriga, Daniela Patrícia Martins Dias Pedroso, Eva D. Carvalho, Kacper A Walentynowicz, Sofia P. das Neves, Kapil Sharma, Joana Mateus
Publikováno v:
Glia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be75cc1e24a07b11a9d5f047975ec56
https://doi.org/10.1002/glia.23675
https://doi.org/10.1002/glia.23675
Autor:
Mikaela Laine, Marie Baekved Hansen, Thomas Damm Als, Ole Mors, Preben Bo Mortensen, Marianne Giørtz Pedersen, Iiris Hovatta, Jonas Bybjerg-Grauholm, Sandra Meier, Anders D. Børglum, Kalevi Trontti, Ewa Sokolowska, Manuel Mattheisen, Merete Nordentoft, David M. Hougaard, Thomas Werge
Anxiety and stress-related disorders (ASRD) are among the most common mental disorders with the majority of patients suffering from additional disorders. Family and twin studies indicate that genetic and environmental factors are underlying their eti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a6581a388d12fe3fe8d6474a21f5c5
https://doi.org/10.1101/263855
https://doi.org/10.1101/263855
Autor:
Suvi Saarnio, Aino Heikkinen, Jaana Suvisaari, Eva Rikandi, Mikaela Laine, Zuzanna Misiewicz, Ingrid Balcells, Outi Mantere, Natalia Kulesskaya, Eija Jokitalo, Iiris Hovatta, Tuula Kieseppä, Kalevi Trontti, Dario Greco, Ewa Sokolowska, Tuukka T. Raij
Publikováno v:
European Neuropsychopharmacology. 29:S498-S499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e69683b2c6fbd620eb35c5dd4d3639ce
https://doi.org/10.1016/j.euroneuro.2018.11.744
https://doi.org/10.1016/j.euroneuro.2018.11.744
Autor:
Mikaela Laine, Mateusz Dudek, Iiris Hovatta, Saija-Anita Callan, Petri Hyytiä, Ewa Sokolowska
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c551a845a88217e9f253c50d631e275f
http://hdl.handle.net/10138/228796
http://hdl.handle.net/10138/228796
Autor:
Kalevi Trontti, Vootele Voikar, Darina Czamara, Jade Martins, Mikaela Laine, Luis Rodrigues, Christiane Rewerts, Natalia Kulesskaya, Stella Iurato, R. Zuzanna Misiewicz, Alon Chen, Lars Paulin, Giuseppina Maccarrone, Laura Salminen, Dong Ik Park, Ewa Sokolowska, Eija Jokitalo, Christoph W. Turck, Naama Volk, Angelika Erhardt, Iiris Hovatta, Bozidar Novak, Petri Auvinen
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008358 (2019)
PLoS Genetics
PLoS Genetics
Stressful life events are major environmental risk factors for anxiety disorders, although not all individuals exposed to stress develop clinical anxiety. The molecular mechanisms underlying the influence of environmental effects on anxiety are large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea5380756d882d916ab946238df3d13
https://doi.org/10.1371/journal.pgen.1008358
https://doi.org/10.1371/journal.pgen.1008358
Autor:
Jakob Grove, Preben Bo Mortensen, Ewa Sokolowska, Kalevi Trontti, Sandra Meier, Mikaela Laine, Iiris Hovatta, Manuel Mattheisen, Anders D. Børglum, Jonas Bybjerg-Grauholm, Thalia C. Eley, Thomas Werge, Kirstin L. Purves, Merete Nordentoft, Ole Mors, Thomas Damms Als, David M. Hougaard, Gerome Breen, Marianne Giørtz Pedersen, Marie Bækved-Hansen
Publikováno v:
Meier, S M, Trontti, K, Purves, K L, Als, T D, Grove, J, Laine, M, Pedersen, M G, Bybjerg-Grauholm, J, Bækved-Hansen, M, Sokolowska, E, Mortensen, P B, Hougaard, D M, Werge, T, Nordentoft, M, Breen, G, Børglum, A D, Eley, T C, Hovatta, I, Mattheisen, M & Mors, O 2019, ' Genetic Variants Associated With Anxiety and Stress-Related Disorders : A Genome-Wide Association Study and Mouse-Model Study ', J A M A Psychiatry, vol. 76, no. 9, pp. 924-932 . https://doi.org/10.1001/jamapsychiatry.2019.1119
Importance: Anxiety and stress-related disorders are among the most common mental disorders. Although family and twin studies indicate that both genetic and environmental factors play an important role underlying their etiology, the genetic underpinn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d814d36ed2d31be63e00ce2a019936
https://doi.org/10.1001/jamapsychiatry.2019.1119
https://doi.org/10.1001/jamapsychiatry.2019.1119
CHRONIC PSYCHOSOCIAL STRESS IN MICE ALTERS BRAIN MYELINATION IN A GENETIC BACKGROUNDDEPENDENT MANNER
Autor:
Kalevi Trontti, Mikaela Laine, Eija Jokitalo, Dario Greco, Ingrid Balcells, Iiris Hovatta, Zuzanna Misiewicz, Ewa Sokolowska, Natalia Kulesskaya, Suvi Saarnio
Publikováno v:
European Neuropsychopharmacology. 29:S987
Background Chronic psychosocial stress is a well-established risk factor for anxiety disorders and major depression. Mechanisms by which chronic stress impacts susceptibility and resilience to psychiatric disorders are largely unknown. The Chronic So
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58aa2c26c4f8852a4bd083f20b385cee
https://doi.org/10.1016/j.euroneuro.2017.08.366
https://doi.org/10.1016/j.euroneuro.2017.08.366
Autor:
Suvi Saarnio, Zuzanna Misiewicz, Mikaela Laine, Eija Jokitalo, Lars Paulin, Natalia Kulesskaya, Petri Auvinen, Ingrid Balcells, Pekka Ellonen, Aino Heikkinen, Kalevi Trontti, Dario Greco, Pierre Ameslon, Pirkko Mattila, Iiris Hovatta, Ewa Sokolowska
Publikováno v:
eNeuro
Visual Abstract
Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (C
Anxiety disorders often manifest in genetically susceptible individuals after psychosocial stress, but the mechanisms underlying these gene-environment interactions are largely unknown. We used the chronic social defeat stress (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3f3ca8a7c159c4d6476df81888366b
https://doi.org/10.1523/eneuro.0166-18.2018
https://doi.org/10.1523/eneuro.0166-18.2018