Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mikael Segerstråle"'
Autor:
Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski, Rimante Minkeviciene, Lauri Lahti, Edna C. Hardeman, Peter W. Gunning, Casper C. Hoogenraad, Tomi Taira, Thomas Fath, Pirta Hotulainen
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain neuronal polarity. The AIS actin cytoskeleton comprises actin patches and periodic sub
Externí odkaz:
https://doaj.org/article/3e57b0157379454eb6ea69f71bced384
Autor:
Heidi O Nousiainen, Ileana B Quintero, Timo T Myöhänen, Vootele Voikar, Jelena Mijatovic, Mikael Segerstråle, Annakaisa M Herrala, Natalia Kulesskaya, Anitta E Pulkka, Tanja Kivinummi, Usama Abo-Ramadan, Tomi Taira, T Petteri Piepponen, Heikki Rauvala, Pirkko Vihko
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97851 (2014)
Prostatic acid phosphatase (PAP), the first diagnostic marker and present therapeutic target for prostate cancer, modulates nociception at the dorsal root ganglia (DRG), but its function in the central nervous system has remained unknown. We studied
Externí odkaz:
https://doaj.org/article/6b7849ad9e374ed288cb0da44ab9264c
Autor:
Tarja Joensuu, Saara Tegelberg, Eva Reinmaa, Mikael Segerstråle, Paula Hakala, Heidi Pehkonen, Esa R Korpi, Jaana Tyynelä, Tomi Taira, Iiris Hovatta, Outi Kopra, Anna-Elina Lehesjoki
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89321 (2014)
Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an autosomal recessively inherited neurodegenerative disease, manifesting with myoclonus, seizures and ataxia, caused by mutations in the cystatin B (CSTB) gene. With the aim of und
Externí odkaz:
https://doaj.org/article/efbc09911f944d31a65931d0f21924a6
Autor:
Pirta Hotulainen, Casper C. Hoogenraad, Mikael Segerstråle, Peter W. Gunning, David Micinski, Amr Abouelezz, Edna C. Hardeman, Thomas Fath, Tomi Taira, Rimante Minkeviciene, Holly Stefen, Lauri Lahti
Publikováno v:
iScience, Vol 23, Iss 5, Pp-(2020)
iScience
iScience, 23(5). Elsevier
iScience
iScience, 23(5). Elsevier
Summary The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain neuronal polarity. The AIS actin cytoskeleton comprises actin patches and periodic sub-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e374e770750234797611bcb87c7c3e3e
http://hdl.handle.net/10138/316268
http://hdl.handle.net/10138/316268
Autor:
Thomas Fath, Mikael Segerstråle, Peter W. Gunning, Amr Abouelezz, Rimante Minkeviciene, David Micinski, Pirta Hotulainen, Tomi Taira, Casper C. Hoogenraad, Edna C. Hardeman, Holly Stefen
Publikováno v:
SSRN Electronic Journal.
The axon initial segment (AIS) is the site of action potential initiation and serves as a vesicular filter and diffusion barrier that help maintain neuronal polarity. Recent studies have revealed details about a specialized structural complex in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26388bacc7be6b980de85eb688ecadf7
https://doi.org/10.2139/ssrn.3448139
https://doi.org/10.2139/ssrn.3448139
Autor:
Mikko Koskinen, Tomi Taira, Rimante Minkeviciene, Pirta Hotulainen, Jonas Englund, Eero Castrén, Mikael Segerstråle, Enni Bertling
Publikováno v:
The Journal of Neuroscience. 36:5299-5313
Rapid reorganization and stabilization of the actin cytoskeleton in dendritic spines enables cellular processes underlying learning, such as long-term potentiation (LTP). Dendritic spines are enriched in exceptionally short and dynamic actin filament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cad9f50de562a98bbaaf812d5a439e
https://doi.org/10.1523/jneurosci.2649-15.2016
https://doi.org/10.1523/jneurosci.2649-15.2016
Autor:
Juha Saarikangas, Geneviève Chazal, Lore Becker, Valerie Gailus-Durner, Yosuke Senju, Rimante Minkeviciene, Thomas Klopstock, Martin Hrabě de Angelis, Lotta von Ossowski, Tomi Taira, Helmut Fuchs, Wolfgang Hans, Lillian Garrett, Sabine M. Hölter, Andreas Zimmer, Nazim Kourdougli, Pirta Hotulainen, Claudio Rivera, Ildiko Racz, Jaakko Kuurne, Pieta K. Mattila, Wolfgang Wurst, Mikael Segerstråle, Pekka Lappalainen
Publikováno v:
Dev. Cell 33, 644-659 (2015)
Developmental cell 33(6), 644-659 (2015). doi:10.1016/j.devcel.2015.04.014
Developmental cell 33(6), 644-659 (2015). doi:10.1016/j.devcel.2015.04.014
SummaryProper morphogenesis of neuronal dendritic spines is essential for the formation of functional synaptic networks. However, it is not known how spines are initiated. Here, we identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68204dd715fc46291e65a034be0a265b
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8370f5f52a9947b23d109ee46cf537ff
http://hdl.handle.net/10138/233538
http://hdl.handle.net/10138/233538
Autor:
Sari E. Lauri, Christophe Mulle, Tomi Taira, Juuso Juuri, Frederic Lanore, Mikael Segerstråle, Petteri Piepponen
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2010, 30, pp.6507-6514. ⟨10.1523/jneurosci.4856-09.2010⟩
Journal of Neuroscience, Society for Neuroscience, 2010, 30, pp.6507-6514. ⟨10.1523/jneurosci.4856-09.2010⟩
In the neonatal hippocampus, the activity of interneurons shapes early network bursts that are important for the establishment of neuronal connectivity. However, mechanisms controlling the firing of immature interneurons remain elusive. We now show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edb5c5cd89e8342b1ce2d94d7844e4a
https://doi.org/10.1523/jneurosci.4856-09.2010
https://doi.org/10.1523/jneurosci.4856-09.2010
Publikováno v:
Neuropharmacology. 52:1354-1365
Kainate type of glutamate receptors (KARs) modulate synaptic transmission in a developmentally regulated manner at several synapses in the brain. Previous studies have shown that KARs depress glutamatergic transmission at CA3-CA1 synapses in the hipp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcd9957c81ca25d87428118d62f55eb
https://doi.org/10.1016/j.neuropharm.2007.01.015
https://doi.org/10.1016/j.neuropharm.2007.01.015