Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Mikael Rørdam Andersen"'
Autor:
Alexandra Lensch, Hanna Abbas Lindfors, Elke Duwenig, Tobias Fleischmann, Carsten Hjort, Sirpa O. Kärenlampi, Lucie McMurtry, Emily-Denise Melton, Mikael Rørdam Andersen, Ryan Skinner, Markus Wyss, Richard van Kranenburg
Publikováno v:
EFB Bioeconomy Journal, Vol 4, Iss , Pp 100061- (2024)
Microorganisms are used in a variety of sectors, including food and feed production, agricultural or environmental applications, and can be optimized for efficacy, safety and sustainability using modern biotechnology techniques. In the EU, geneticall
Externí odkaz:
https://doaj.org/article/232f984d74f94b5db7fbac0831b9d769
Autor:
Cyrielle Calmels, Solène Arnoult, Bassem Ben Yahia, Laetitia Malphettes, Mikael Rørdam Andersen
Publikováno v:
Metabolic Engineering Communications, Vol 9, Iss , Pp - (2019)
Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies. However, the process and feeding regimes need to be adapted for each new cell line, as they all
Externí odkaz:
https://doaj.org/article/6b099d7f904f44c0a2af362e0e25076f
Publikováno v:
Synthetic and Systems Biotechnology, Vol 1, Iss 2, Pp 122-129 (2016)
Introduction: Secondary metabolites of fungi are receiving an increasing amount of interest due to their prolific bioactivities and the fact that fungal biosynthesis of secondary metabolites often occurs from co-regulated and co-located gene clusters
Externí odkaz:
https://doaj.org/article/f9dfd11a091c42c7896c662a01798840
Autor:
Maria Lund Nielsen, Thomas Isbrandt, Lene Maj Petersen, Uffe Hasbro Mortensen, Mikael Rørdam Andersen, Jakob Blæsbjerg Hoof, Thomas Ostenfeld Larsen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161199 (2016)
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions. Rational genetic engineering for the pr
Externí odkaz:
https://doaj.org/article/f284e1d4d4a44036922938a659419dfd
Autor:
Olena P Ishchuk, Tanja Vojvoda Zeljko, Anna J Schifferdecker, Sofia Mebrahtu Wisén, Åsa K Hagström, Elżbieta Rozpędowska, Mikael Rørdam Andersen, Linda Hellborg, Zhihao Ling, Andrei A Sibirny, Jure Piškur
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161741 (2016)
The wine and beer yeast Dekkera bruxellensis thrives in environments that are harsh and limiting, especially in concentrations with low oxygen and high ethanol. Its different strains' chromosomes greatly vary in number (karyotype). This study isolate
Externí odkaz:
https://doaj.org/article/907e194d5c404cb4a3291066ddf3e050
Autor:
Line Ledsgaard, Timothy P. Jenkins, Kristian Davidsen, Kamille Elvstrøm Krause, Andrea Martos-Esteban, Mikael Engmark, Mikael Rørdam Andersen, Ole Lund, Andreas Hougaard Laustsen
Publikováno v:
Toxins, Vol 10, Iss 10, p 393 (2018)
Antivenom cross-reactivity has been investigated for decades to determine which antivenoms can be used to treat snakebite envenomings from different snake species. Traditionally, the methods used for analyzing cross-reactivity have been immunodiffusi
Externí odkaz:
https://doaj.org/article/461eb042303146c099bd9fe94664a87d
Autor:
Anne Mathilde Lund, Helene Faustrup Kildegaard, Maja Borup Kjær Petersen, Julie Rank, Bjarne Gram Hansen, Mikael Rørdam Andersen, Uffe Hasbro Mortensen
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96693 (2014)
A new versatile mammalian vector system for protein production, cell biology analyses, and cell factory engineering was developed. The vector system applies the ligation-free uracil-excision based technique--USER cloning--to rapidly construct mammali
Externí odkaz:
https://doaj.org/article/181d730b6705404b876e3f3957db1fb4
Autor:
Morten Thrane Nielsen, Marie Louise Klejnstrup, Marko Rohlfs, Diana Chinyere Anyaogu, Jakob Blæsbjerg Nielsen, Charlotte Held Gotfredsen, Mikael Rørdam Andersen, Bjarne Gram Hansen, Uffe Hasbro Mortensen, Thomas Ostenfeld Larsen
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73369 (2013)
Secondary metabolites are known to serve a wide range of specialized functions including communication, developmental control and defense. Genome sequencing of several fungal model species revealed that the majority of predicted secondary metabolite
Externí odkaz:
https://doaj.org/article/8f54415ad07549319c69283e7dce52cf
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50596 (2012)
Acid formation in Aspergillus niger is known to be subjected to tight regulation, and the acid production profiles are fine-tuned to respond to the ambient pH. Based on transcriptome data, putative trans-acting pH responding transcription factors wer
Externí odkaz:
https://doaj.org/article/35edff334f26455b8c3d4745359abb89
Autor:
Laetitia Malphettes, Mikael Rørdam Andersen, Christopher T. Workman, Valentine Chevallier, Erwin M. Schoof
Publikováno v:
Biotechnology and Bioengineering
Chevallier, V, Schoof, E M, Malphettes, L, Andersen, M R & Workman, C T 2020, ' Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis ', Biotechnology and Bioengineering, vol. 117, no. 11, pp. 3448-3458 . https://doi.org/10.1002/bit.27495
Chevallier, V, Schoof, E M, Malphettes, L, Andersen, M R & Workman, C T 2020, ' Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis ', Biotechnology and Bioengineering, vol. 117, no. 11, pp. 3448-3458 . https://doi.org/10.1002/bit.27495
Glutathione (GSH) plays a central role in the redox balance maintenance in mammalian cells. Previous studies of industrial Chinese hamster ovary cell lines have demonstrated a relationship between GSH metabolism and clone productivity. However, a tho