Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mikael Marttinen"'
Autor:
Heidi Peussa, Chiara Fedele, Huy Tran, Mikael Marttinen, Julia Fadjukov, Elina Mäntylä, Arri Priimägi, Soile Nymark, Teemu O. Ihalainen
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract Epithelial cells are in continuous dynamic biochemical and physical interaction with their extracellular environment. Ultimately, this interplay guides fundamental physiological processes. In these interactions, cells generate fast local and
Externí odkaz:
https://doaj.org/article/d88e42f2ddbb42e5a79f67ff5045a731
Autor:
Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M. Mäkinen, Petri Mäkinen, Saša Končarević, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen, Henna Martiskainen, Susanna Kemppainen, Mikael Marttinen, Heli Jeskanen, Hannah Rostalski, Eija Rahunen, Miia Kivipelto, Tiia Ngandu, Teemu Natunen, Jean-Charles Lambert, Rudolph E. Tanzi, Doo Yeon Kim, Tuomas Rauramaa, Sanna-Kaisa Herukka, Hilkka Soininen, Markku Laakso, Ian Pike, Ville Leinonen, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106140- (2023)
The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer's disease (AD). Thereafter, different studies have discovered that the carriers of the APP A673T variant show r
Externí odkaz:
https://doaj.org/article/b8c8b78d1c5947a18f0f68c753c65493
Autor:
Teemu Natunen, Henna Martiskainen, Mikael Marttinen, Sami Gabbouj, Hennariikka Koivisto, Susanna Kemppainen, Satu Kaipainen, Mari Takalo, Helena Svobodová, Luukas Leppänen, Benjam Kemiläinen, Simo Ryhänen, Teemu Kuulasmaa, Eija Rahunen, Sisko Juutinen, Petra Mäkinen, Pasi Miettinen, Tuomas Rauramaa, Jussi Pihlajamäki, Annakaisa Haapasalo, Ville Leinonen, Heikki Tanila, Mikko Hiltunen
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-30 (2020)
Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms un
Externí odkaz:
https://doaj.org/article/0a5157aefa5741f49d346794317e84b4
Autor:
Catarina B. Ferreira, Mikael Marttinen, Joana E. Coelho, Kaisa M.A. Paldanius, Mari Takalo, Petra Mäkinen, Luukas Leppänen, Catarina Miranda-Lourenço, João Fonseca-Gomes, Sara R. Tanqueiro, Sandra H. Vaz, Rita F. Belo, Ana Maria Sebastião, Ville Leinonen, Hilkka Soininen, Ian Pike, Annakaisa Haapasalo, Luísa V. Lopes, Alexandre de Mendonça, Maria José Diógenes, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105603- (2022)
Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Prev
Externí odkaz:
https://doaj.org/article/64ca49ebf34d4f8fba3b77430bcc78cd
Autor:
Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare c
Externí odkaz:
https://doaj.org/article/c122113eda2b4d76853cce27dfc51d97
Autor:
Mikael Marttinen, Jussi Paananen, Antonio Neme, Vikram Mitra, Mari Takalo, Teemu Natunen, Kaisa M.A. Paldanius, Petra Mäkinen, Michael Bremang, Mitja I. Kurki, Tuomas Rauramaa, Ville Leinonen, Hilkka Soininen, Annakaisa Haapasalo, Ian Pike, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 454-468 (2019)
No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and p
Externí odkaz:
https://doaj.org/article/1fe019b20534486d87a8b1561727acb5
Autor:
Henna Martiskainen, Kaisa M. A. Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer’s
Externí odkaz:
https://doaj.org/article/6ffdfce30aa34abe808f0d76198110f4
Autor:
Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natunen
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin signaling, is a common co-morbidity and a risk factor for AD, incre
Externí odkaz:
https://doaj.org/article/15215aa0ee3d4acfb1f0bd56cde7b958
Autor:
Hannah Rostalski, Stina Leskelä, Nadine Huber, Kasper Katisko, Antti Cajanus, Eino Solje, Mikael Marttinen, Teemu Natunen, Anne M. Remes, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with a complex, but often overlapping, genetic and pathobiological background and thus they are considered to form a disease spectrum. Alt
Externí odkaz:
https://doaj.org/article/e1d3a20842544134bab22774b056de7e
Autor:
Mikael Marttinen, Mari Takalo, Teemu Natunen, Rebekka Wittrahm, Sami Gabbouj, Susanna Kemppainen, Ville Leinonen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is clinically associated with a global cognitive decline and progressive loss of memory and reasoning. According to the prevailing amyloid cascade hypothesis of AD, incre
Externí odkaz:
https://doaj.org/article/6f679eb2278c49e0b4c93bf596c990eb