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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.

Autor: Chen CCL; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Deshmukh S; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada., Jessa S; Quantitative Life Sciences, McGill University, Montreal, QC H3A 2A7, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada., Hadjadj D; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Lisi V; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Andrade AF; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Faury D; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Jawhar W; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Dali R; Canadian Centre for Computational Genomics, McGill University, Montreal, QC H3A 0E9, Canada., Suzuki H; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Pathania M; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; CRUK Children's Brain Tumour Centre of Excellence, University of Cambridge, Cambridge CB2 0RE, UK., A D; Nuclear Function in CNS Pathophysiology, German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Dubois F; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA., Woodward E; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA., Hébert S; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada., Coutelier M; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada., Karamchandani J; Department of Pathology, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Albrecht S; Department of Pathology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Brandner S; UCL Queen Square Institute of Neurology, London WC1N 3BG, UK., De Jay N; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada., Gayden T; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Bajic A; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Harutyunyan AS; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Marchione DM; Department of Biochemistry and Biophysics and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Mikael LG; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Juretic N; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Zeinieh M; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada., Russo C; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Maestro N; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK., Bassenden AV; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada., Hauser P; Second Department of Paediatrics, Semmelweis University, Budapest 1094, Hungary., Virga J; Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary; Department of Oncology, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary., Bognar L; Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary., Klekner A; Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary., Zapotocky M; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Vicha A; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Krskova L; Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Vanova K; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Zamecnik J; Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Sumerauer D; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague 150 06, Czech Republic., Ekert PG; Children's Cancer Center, The Royal Children's Hospital; Murdoch Children's Research Institute; Department of Pediatrics, University of Melbourne, Parkville, VIC 3052, Australia., Ziegler DS; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031, Australia; School of Women's and Children's Health, UNSW Sydney, Kensington, NSW 2052, Australia., Ellezam B; Department of Pathology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada., Filbin MG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA., Blanchette M; School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada., Hansford JR; Children's Cancer Center, The Royal Children's Hospital; Murdoch Children's Research Institute; Department of Pediatrics, University of Melbourne, Parkville, VIC 3052, Australia., Khuong-Quang DA; Children's Cancer Center, The Royal Children's Hospital; and Murdoch Children's Research Institute; Parkville, VIC 3052, Australia., Berghuis AM; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada., Weil AG; Department of Pediatric Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada., Garcia BA; Department of Biochemistry and Biophysics and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6073, USA., Garzia L; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada; Division of Orthopedic Surgery, Faculty of Surgery, McGill University, Montreal, QC H3G 1A4, Canada., Mack SC; Department of Pediatrics, Division of Hematology and Oncology, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA., Beroukhim R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA; Broad Institute of MIT and Harvard, Boston, MA 02142, USA., Ligon KL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA; Department of Pathology, Boston Children's Hospital and Brigham and Women's Hospital, Harvard Medical School, and Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Taylor MD; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Bandopadhayay P; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Kramm C; Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen 37075, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ) and Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Heidelberg 69120, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany., Korshunov A; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany., Sturm D; Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen 37075, Germany; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Jones DTW; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg 69120, Germany., Salomoni P; Department of Oncology and The Milner Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Nuclear Function in CNS Pathophysiology, German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany., Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC H3T 1E2, Canada. Electronic address: claudia.kleinman@mcgill.ca., Jabado N; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address: nada.jabado@mcgill.ca.

Publikováno v: Cell [Cell] 2020 Dec 10; Vol. 183 (6), pp. 1617-1633.e22. Date of Electronic Publication: 2020 Nov 30.

Stalled developmental programs at the root of pediatric brain tumors.

Autor: Jessa S; Quantitative Life Sciences, McGill University, Montreal, Quebec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada., Blanchet-Cohen A; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Krug B; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Vladoiu M; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Coutelier M; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Faury D; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Poreau B; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.; Service de Génétique et Procréation, Centre Hospitalier Universitaire, Grenoble-Alpes, Grenoble, France., De Jay N; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Hébert S; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Monlong J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, CA, USA., Farmer WT; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Donovan LK; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Hu Y; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., McConechy MK; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Cavalli FMG; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Mikael LG; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.; The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Ellezam B; Department of Pathology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Richer M; Department of Pathology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Allaire A; Department of Pathology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Weil AG; Department of Pediatric Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Atkinson J; Department of Pediatric Surgery, Division of Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, Querbec, Canada., Farmer JP; Department of Pediatric Surgery, Division of Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, Querbec, Canada., Dudley RWR; Department of Pediatric Surgery, Division of Neurosurgery, Montreal Children's Hospital, McGill University, Montreal, Querbec, Canada., Larouche V; Department of Pediatrics, Centre mère-enfant Soleil du CHU de Québec-Université Laval, Quebec City, Quebec, Canada., Crevier L; Department of Surgery, Université de Laval, Quebec City, Quebec, Canada., Albrecht S; Department of Pathology, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada., Filbin MG; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Boston, MA, USA., Sartelet H; Department of Pathology, Centre Hospitalier Universitaire de Grenoble, Grenoble, France., Lutz PE; Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Nagy C; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Turecki G; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada., Costantino S; Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.; Department of Ophthalmology, Université de Montréal, Montreal, Quebec, Canada., Dirks PB; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Murai KK; Centre for Research in Neuroscience, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Bourque G; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.; Canadian Center for Computational Genomics, Montreal, Quebec, Canada., Ragoussis J; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada., Garzia L; Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Division of Orthopedic Surgery, Faculty of Surgery, McGill University, Montreal, Quebec, Canada., Taylor MD; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com., Jabado N; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. nada.jabado@mcgill.ca.; Department of Pediatrics, McGill University, Montreal, Quebec, Canada. nada.jabado@mcgill.ca.; The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada. nada.jabado@mcgill.ca., Kleinman CL; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. claudia.kleinman@mcgill.ca.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. claudia.kleinman@mcgill.ca.

Publikováno v: Nature genetics [Nat Genet] 2019 Dec; Vol. 51 (12), pp. 1702-1713. Date of Electronic Publication: 2019 Nov 25.