Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mikael Kozyra"'
Autor:
Paola Nolé, Britt Duijndam, Adam Stenman, C Christofer Juhlin, Mikael Kozyra, Catharina Larsson, Magnus Ingelman-Sundberg, Inger Johansson
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162379 (2016)
Human cytochome P450 2W1 (CYP2W1) enzyme is expressed in fetal colon and in colon tumors. The level of expression is higher in colon metastases than in the parent tumors and the enzyme is a possible drug target for treatment of colorectal cancer, as
Externí odkaz:
https://doaj.org/article/ff9c1d5a9fd742749d354195a0e247fb
Autor:
Oveis Jamialahmadi, Annika Janefeldt, Carl Whatling, Luca Valenti, Mikael Kozyra, Kajsa P. Kanebratt, Tommy B. Andersson, Arturo Pujia, Paola Dongiovanni, Andrea Caddeo, Rosellina Margherita Mancina, Sebastian Prill, Magnus Ingelman-Sundberg, Stefano Romeo, Raffaela Rametta, Daniel Lindén, Guido Baselli, Piero Pingitore
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
There is a high unmet need for developing treatments for nonalcoholic fatty liver disease (NAFLD), for which there are no approved drugs today. Here, we used a human in vitro disease model to understand mechanisms linked to genetic risk variants asso
Autor:
Zhengbing Zhuge, Chiara Moretti, Jon O. Lundberg, Marcelo F. Montenegro, Magnus Ingelman-Sundberg, Han Huirong, Josiane C. Cruz, Maria Peleli, Andrei L. Kleschyov, Sarah McCann Haworth, Mattias Carlström, Eddie Weitzberg, Mikael Kozyra, Mayara Caldeira-Dias, Isabel Cordero-Herrera, Arghavan Jahandideh
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Liver steatosis, or fatty liver, is the most common liver disease in the world, affecting up to 25% of all Americans. There is currently no approved drug available for this condition, which may progress to serious disease, including stea
Publikováno v:
Genetics in Medicine. 19:20-29
In this study we characterized the genetic variability of 146 clinically relevant genes influencing drug pharmacokinetics in African and European subpopulations, which are key determinants for interindividual variations in drug efficacy and adverse d
Autor:
Britt Duijndam, Paola Nolé, Adam Stenman, Mikael Kozyra, Catharina Larsson, C. Christofer Juhlin, Magnus Ingelman-Sundberg, Inger Johansson
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162379 (2016)
PLoS ONE
PLoS ONE
Human cytochome P450 2W1 (CYP2W1) enzyme is expressed in fetal colon and in colon tumors. The level of expression is higher in colon metastases than in the parent tumors and the enzyme is a possible drug target for treatment of colorectal cancer, as
Autor:
Åsa Nordling, Volker M. Lauschke, Shahid Ullah, Magnus Ingelman-Sundberg, Mikael Kozyra, Inger Johansson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health concern as reflected in its widespread distribution in the general population. Yet, treatment options are scarce which is at least in part due to lack of reliable human in vitro