Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Mikael J Pittet"'
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Anie Azroyan, Virna Cortez-Retamozo, Richard Bouley, Rachel Liberman, Ye Chun Ruan, Evgeny Kiselev, Kenneth A Jacobson, Mikael J Pittet, Dennis Brown, Sylvie Breton
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121419 (2015)
Uncontrolled inflammation is one of the leading causes of kidney failure. Pro-inflammatory responses can occur in the absence of infection, a process called sterile inflammation. Here we show that the purinergic receptor P2Y14 (GPR105) is specificall
Externí odkaz:
https://doaj.org/article/e26b6902856e46068197796a4c3de6c7
Autor:
Ken S Lau, Virna Cortez-Retamozo, Sarah R Philips, Mikael J Pittet, Douglas A Lauffenburger, Kevin M Haigis
Publikováno v:
PLoS Biology, Vol 10, Iss 9, p e1001393 (2012)
Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells
Externí odkaz:
https://doaj.org/article/d1766cb9d5cd45989788fac10b361db7
Autor:
Moritz Wildgruber, Hakho Lee, Aleksey Chudnovskiy, Tae-Jong Yoon, Martin Etzrodt, Mikael J Pittet, Matthias Nahrendorf, Kevin Croce, Peter Libby, Ralph Weissleder, Filip K Swirski
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5663 (2009)
Monocytes are circulating macrophage and dendritic cell precursors that populate healthy and diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate in response to coronary artery disease, sepsis
Externí odkaz:
https://doaj.org/article/b8875df223a04622b898f2891ff108ba
Autor:
Filip K Swirski, Cedric R Berger, Jose-Luiz Figueiredo, Thorsten R Mempel, Ulrich H von Andrian, Mikael J Pittet, Ralph Weissleder
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1075 (2007)
The complexity of the tumor microenvironment necessitates that cell behavior is studied in a broad, multi-scale context. Although tomographic and microscopy-based far and near infrared fluorescence (NIRF, >650 nm) imaging methods offer high resolutio
Externí odkaz:
https://doaj.org/article/85634bde2aa94ff5b754912ffbe23447
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 29:1605-1619
Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechan
Autor:
Jina Ko, Martin Wilkovitsch, Juhyun Oh, Rainer H. Kohler, Evangelia Bolli, Mikael J. Pittet, Claudio Vinegoni, David B. Sykes, Hannes Mikula, Ralph Weissleder, Jonathan C. T. Carlson
Publikováno v:
Nat Biotechnol
Cells in complex organisms undergo frequent functional changes, but few methods allow comprehensive longitudinal profiling of living cells. Here we introduce scission-accelerated fluorophore exchange (SAFE), a method for multiplexed temporospatial im
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Venn plots and selected GSEA pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aa766e188dfb7efdbae9354c85712c
https://doi.org/10.1158/1078-0432.22633054.v1
https://doi.org/10.1158/1078-0432.22633054.v1
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Longitudinal analysis of circulating biomarkers in the plasma of treated patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f148ae1cbc18e85df3cde2c1dc852
https://doi.org/10.1158/1078-0432.22633018.v1
https://doi.org/10.1158/1078-0432.22633018.v1
Autor:
Mikael J. Pittet, Allon M. Klein, Ralph Weissleder, Virginia Savova, Rainer H. Kohler, Maaz S. Ahmed, Jeremy Quintana, Michael F. Cuccarese, Christopher B. Rodell, Angela N. Marquard, Melissa M. Sprachman, Jeremy Gungabeesoon, Marie Siwicki, Ruben Bill, Yunkang Lin, Nicolas A. Gort-Freitas, Steffen Rickelt, Angela E. Zou, Marius Messemaker, Camilla Engblom, Rapolas Zilionis, Christina Pfirschke
Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03be49f542113058bc6ec50af244fe65
https://doi.org/10.1158/2326-6066.22544211
https://doi.org/10.1158/2326-6066.22544211