Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Mikael J, Pittet"'
Autor:
Mariia Bilous, Loc Tran, Chiara Cianciaruso, Aurélie Gabriel, Hugo Michel, Santiago J. Carmona, Mikael J. Pittet, David Gfeller
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Single-cell RNA sequencing (scRNA-seq) technologies offer unique opportunities for exploring heterogeneous cell populations. However, in-depth single-cell transcriptomic characterization of complex tissues often requires profiling
Externí odkaz:
https://doaj.org/article/d0af27f00f2645789cfbb5caba1f4daf
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new
Externí odkaz:
https://doaj.org/article/d3653b7e42a14239a9541459d01f0ce4
Autor:
Ruben Bill, Daniel G. Deschler, Mikael J. Pittet, Sara I. Pai, Peter M. Sadow, Jong Chul Park
Publikováno v:
Cancer Reports, Vol 5, Iss 3, Pp n/a-n/a (2022)
Abstract Background Secretory carcinoma is a more recently described subtype of salivary gland carcinoma that may pose diagnostic challenges and frequently harbors NTRK fusions that may successfully be targeted by TRK inhibitors in advanced disease.
Externí odkaz:
https://doaj.org/article/3502dd3b3d334ee6b7ccb156233cf336
Autor:
Hsin-Wei Liao, Christopher Garris, Christina Pfirschke, Steffen Rickelt, Sean Arlauckas, Marie Siwicki, Rainer H. Kohler, Ralph Weissleder, Vibeke Sundvold-Gjerstad, Baldur Sveinbjørnsson, Øystein Rekdal, Mikael J. Pittet
Publikováno v:
Cell Stress, Vol 3, Iss 11, Pp 348-360 (2019)
LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of canc
Externí odkaz:
https://doaj.org/article/3c2d5b260fbe4adb94f8a76380519ac6
Autor:
Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell de
Externí odkaz:
https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 29:1605-1619
Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a172e9457377d283c4f90bae25db37f3
https://doi.org/10.1158/1078-0432.ccr-22-1630
https://doi.org/10.1158/1078-0432.ccr-22-1630
Autor:
Christina Pfirschke, Camilla Engblom, Jeremy Gungabeesoon, Yunkang Lin, Steffen Rickelt, Rapolas Zilionis, Marius Messemaker, Marie Siwicki, Genevieve M. Gerhard, Anna Kohl, Etienne Meylan, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108164- (2020)
Summary: Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some
Externí odkaz:
https://doaj.org/article/dc64c52451794ba69d2b5d595d53e806
Autor:
Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet, Ralph Weissleder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lun
Externí odkaz:
https://doaj.org/article/a3110620e30e417bbd3502f5ec747b02
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Top 30 upregulated and 30 downregulated genes in treatment group versus untreated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb52c079de5919567f22e864e189c0
https://doi.org/10.1158/1078-0432.22633027.v1
https://doi.org/10.1158/1078-0432.22633027.v1
