Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mikael E. Sellin"'
Autor:
Evgeniya Mickols, Alina Meyer, Niklas Handin, Malin Stüwe, Jens Eriksson, Jakob Rudfeldt, Kristin Blom, Mårten Fryknäs, Mikael E. Sellin, Volker M. Lauschke, Maria Karlgren, Per Artursson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract 3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over weeks in culture. As a result, 3D PHH are gaining importance as a model for mechani
Externí odkaz:
https://doaj.org/article/14b6909630ac42c4af6b2cef75b8a422
Autor:
Stina Hellman, Frida Martin, Eva Tydén, Mikael E. Sellin, Albin Norman, Bernt Hjertner, Pia Svedberg, Caroline Fossum
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-15 (2024)
Abstract Stem cell-derived organoid cultures have emerged as attractive experimental models for infection biology research regarding various types of gastro-intestinal pathogens and host species. However, the large size of infectious nematode larvae
Externí odkaz:
https://doaj.org/article/53640d19141e48ddb8fb6e9eb7bd6b39
Autor:
Christopher von Beek, Anna Fahlgren, Petra Geiser, Maria Letizia Di Martino, Otto Lindahl, Grisna I. Prensa, Erika Mendez-Enriquez, Jens Eriksson, Jenny Hallgren, Maria Fällman, Gunnar Pejler, Mikael E. Sellin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mast cells localize to mucosal tissues and contribute to innate immune defense against infection. How mast cells sense, differentiate between, and respond to bacterial pathogens remains a topic of ongoing debate. Using the prototype enteropa
Externí odkaz:
https://doaj.org/article/d1cf4a9e992844f8a5cdf7afab5f5fd2
Autor:
Sofia Bergman, Liis Andresen, Jonas Kjellin, Yolanda Martinez Burgo, Petra Geiser, Sophie Baars, Fredrik Söderbom, Mikael E. Sellin, Erik Holmqvist
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTGastrointestinal disease caused by Salmonella enterica is associated with the pathogen’s ability to replicate within epithelial cells and macrophages. Upon host cell entry, the bacteria express a type-three secretion system encoded within S
Externí odkaz:
https://doaj.org/article/2452475d32424a88af6d63d1840b3985
Autor:
Ersin Gül, Jemina Huuskonen, Andrew Abi Younes, Luca Maurer, Ursina Enz, Jakob Zimmermann, Mikael E. Sellin, Erik Bakkeren, Wolf-Dietrich Hardt
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113925- (2024)
Summary: Salmonella Typhimurium (S.Tm) utilizes the chemotaxis receptor Tsr to exploit gut inflammation. However, the characteristics of this exploitation and the mechanism(s) employed by the pathogen to circumvent antimicrobial effects of inflammati
Externí odkaz:
https://doaj.org/article/764260268a954cffa30251e5f2f0072a
Autor:
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl‐Henrik Heldin, Aristidis Moustakas
Publikováno v:
Molecular Oncology, Vol 16, Iss 12, Pp 2330-2354 (2022)
Transforming growth factor β (TGFβ) induces epithelial–mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal–epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic coloniza
Externí odkaz:
https://doaj.org/article/efbbbf26dd9f4806acc431c346def40f
Autor:
Jorik M. van Rijn, Jens Eriksson, Jana Grüttner, Magnus Sundbom, Dominic-Luc Webb, Per M. Hellström, Staffan G. Svärd, Mikael E. Sellin
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Interactions between individual pathogenic microbes and host tissues involve fast and dynamic processes that ultimately impact the outcome of infection. Using live-cell microscopy, these dynamics can be visualized to study, e.g., microbe mot
Externí odkaz:
https://doaj.org/article/ba3b486d43254a5a817abe796f7a9578
Autor:
Petra Geiser, Maria Letizia Di Martino, Pilar Samperio Ventayol, Jens Eriksson, Eduardo Sima, Anas Kh. Al-Saffar, David Ahl, Mia Phillipson, Dominic-Luc Webb, Magnus Sundbom, Per M. Hellström, Mikael E. Sellin
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Pathogenic gut bacteria are common causes of intestinal disease. Enteroids—cultured three-dimensional replicas of the mammalian gut—offer an emerging model system to study disease mechanisms under conditions that recapitulate key features of the
Externí odkaz:
https://doaj.org/article/0404c004b7a948ba8fd42e2c92a17f39
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Bacterial host cell invasion mechanisms depend on the bacterium’s virulence factors and the properties of the target cell. The enteropathogen Salmonella enterica serovar Typhimurium (S.Tm) invades epithelial cell types in the gut mucosa an
Externí odkaz:
https://doaj.org/article/949443819dbf4df88e2b44fb131cb234
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2665-2678.e3 (2019)
Summary: Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studie
Externí odkaz:
https://doaj.org/article/af915271baa148419b5b661abac1c64f