Výsledky vyhledávání - "Mikael C I, Karlsson"

Akademický článek

Deficiency of mature B cells does not alter the atherogenic response to castration in male mice

Autor: Anna S. Wilhelmson, Inger Johansson, Linda Fogelstrand, Johan Bourghardt Fagman, Jean-Francois Arnal, Mikael C. I. Karlsson, Åsa Tivesten

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)

Abstract Testosterone deficiency in men is associated with increased atherosclerosis burden and increased cardiovascular risk. In male mice, testosterone deficiency induced by castration increases atherosclerosis as well as mature B cell numbers in s

Externí odkaz: https://doaj.org/article/65d58c0ac98f437c848030b1574124b7

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Akademický článek

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Autor: Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran, Konstantinos Vazaios, Sylwia Libard, Tiarne van de Walle, Maria Georganaki, Hua Huang, Ilkka Pietilä, Joey Lau, Maria H. Ulvmar, Mikael C. I. Karlsson, Maria Zetterling, Sara M. Mangsbo, Asgeir S. Jakola, Thomas Olsson Bontell, Anja Smits, Magnus Essand, Anna Dimberg

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Agonistic CD40 antibodies (αCD40) have broad immunostimulatory properties, however their efficacy in glioma remains unclear. Here the authors show that αCD40 promotes the formation of tertiary lymphoid structures but does not improve survival and i

Externí odkaz: https://doaj.org/article/960c23767579410eb75556847b8c9b3f

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Akademický článek

Actomyosin-driven force patterning controls endocytosis at the immune synapse

Autor: Anita Kumari, Judith Pineau, Pablo J. Sáez, Mathieu Maurin, Danielle Lankar, Mabel San Roman, Katharina Hennig, Vanessa F. Boura, Raphael Voituriez, Mikael C. I. Karlsson, Martial Balland, Ana-Maria Lennon Dumenil, Paolo Pierobon

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protr

Externí odkaz: https://doaj.org/article/153dc305ef9a4480872d0c78f10b8923

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Akademický článek

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticula

Externí odkaz: https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d

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Akademický článek

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype

Autor: Sebastian Lundgren, Emelie Karnevi, Jacob Elebro, Björn Nodin, Mikael C. I. Karlsson, Jakob Eberhard, Karin Leandersson, Karin Jirström

Publikováno v: Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)

Abstract Background Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. These cells are also potential target for immunotherapy as

Externí odkaz: https://doaj.org/article/e70ee1b68bdb47cc82c81ddcf5423cd0

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