Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Mikael Akke"'
Autor:
Maria Luisa Verteramo, Majda Misini Ignjatović, Rohit Kumar, Sven Wernersson, Vilhelm Ekberg, Johan Wallerstein, Göran Carlström, Veronika Chadimová, Hakon Leffler, Fredrik Zetterberg, Derek T. Logan, Ulf Ryde, Mikael Akke, Ulf J. Nilsson
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109636- (2024)
Summary: Halogen bonding is increasingly utilized in efforts to achieve high affinity and selectivity of molecules designed to bind proteins, making it paramount to understand the relationship between structure, dynamics, and thermodynamic driving fo
Externí odkaz:
https://doaj.org/article/04a7dad9b6fc435daabaaf102e239b88
Autor:
Simon Birgersson, Johan Morrill, Olof Stenström, Mathias Wiemann, Ulrich Weininger, Pär Söderhjelm, Mikael Akke, Henrik Stålbrand
Publikováno v:
Catalysts, Vol 13, Iss 9, p 1281 (2023)
β-Mannanases hydrolyze β-mannans, important components of plant and microalgae cell walls. Retaining β-mannanases can also catalyze transglycosylation, forming new β-mannosidic bonds that are applicable for synthesis. This study focused on the bl
Externí odkaz:
https://doaj.org/article/6119ba8797c04ddcb3f1db048d4f1ae6
Publikováno v:
JACS Au, Vol 1, Iss 6, Pp 833-842 (2021)
Externí odkaz:
https://doaj.org/article/e5cf8355c61e45d5841f41eee0a204bc
Autor:
Johan Wallerstein, Vilhelm Ekberg, Majda Misini Ignjatović, Rohit Kumar, Octav Caldararu, Kristoffer Peterson, Sven Wernersson, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke
Publikováno v:
JACS Au, Vol 1, Iss 4, Pp 484-500 (2021)
Externí odkaz:
https://doaj.org/article/2981db6db17549c9b3a2c12397786a4f
Autor:
Raminta Venskutonytė, Ara Koh, Olof Stenström, Muhammad Tanweer Khan, Annika Lundqvist, Mikael Akke, Fredrik Bäckhed, Karin Lindkvist-Petersson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights int
Externí odkaz:
https://doaj.org/article/51b05c6e4427465ea9174681f26b1d76
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3973 (2023)
Plant hemoglobins, often referred to as phytoglobins, play important roles in abiotic stress tolerance. Several essential small physiological metabolites can be bound to these heme proteins. In addition, phytoglobins can catalyze a range of different
Externí odkaz:
https://doaj.org/article/097f878f7f6e40d6bff3c36c0b1888b9
Autor:
Sven Wernersson, Romel Bobby, Liz Flavell, Alexander G. Milbradt, Geoffrey A. Holdgate, Kevin J. Embrey, Mikael Akke
Publikováno v:
Biochemistry. 61:2303-2318
The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact c
Publikováno v:
The Journal of Physical Chemistry B. 126:7950-7956
Aromatic ring flips are a hallmark of protein dynamics. They are experimentally studied by NMR spectroscopy, where recent advances have led to improved characterization across a wide range of time scales. Results on different proteins have been inter
Autor:
Mikael Akke, Ulrich Weininger
Aromatic residues form a significant part of the protein core, where they make tight interactions with multiple surrounding side chains. Despite the dense packing of internal side chains, the aromatic rings of phenylalanine and tyrosine residues unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdc18c3f2395bb07f440081206c5936
Publikováno v:
Journal of Biomolecular Nmr
Aromatic side chains are attractive probes of protein dynamic, since they are often key residues in enzyme active sites and protein binding sites. Dynamic processes on microsecond to millisecond timescales can be studied by relaxation dispersion expe