Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Mikael Adner"'
Autor:
Jesper Bergwik, Jielu Liu, Médea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten, Mikael Adner
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad ran
Externí odkaz:
https://doaj.org/article/dd0575e4dc414befa4090bcfd48ccd10
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Asthma is a common respiratory disease associated with airway hyperresponsiveness (AHR), airway inflammation and mast cell (MC) accumulation in the lung. Monensin, an ionophoric antibiotic, has been shown to induce apoptosis of human MCs. Th
Externí odkaz:
https://doaj.org/article/79437c87e1de4543a03875d5b9a70491
Autor:
Elin Rönnberg, Avinash Ravindran, Luca Mazzurana, Yitao Gong, Jesper Säfholm, Julie Lorent, Olga Dethlefsen, Ann-Charlotte Orre, Mamdoh Al-Ameri, Mikael Adner, Sven-Erik Dahlén, Joakim S. Dahlin, Jenny Mjösberg, Gunnar Nilsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mast cells are tissue-resident cells playing major roles in homeostasis and disease conditions. Lung mast cells are particularly important in airway inflammatory diseases such as asthma. Human mast cells are classically divided into the subsets MCT a
Externí odkaz:
https://doaj.org/article/bd3bec31a2624883b61bd86e30bf60d4
Autor:
Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner
Publikováno v:
Journal of Immunology Research, Vol 2023 (2023)
Background. Asthma is a chronic inflammatory disease with structural changes in the lungs defined as airway remodelling. Mast cell responses are important in asthma as they, upon activation, release mediators inducing bronchoconstriction, inflammator
Externí odkaz:
https://doaj.org/article/e8ad43bf12554b3a955e7226bff0e839
Autor:
Lloyd Tanner, Jesper Bergwik, Ravi K. V. Bhongir, Lang Pan, Caijuan Dong, Olov Wallner, Christina Kalderén, Thomas Helleday, Istvan Boldogh, Mikael Adner, Arne Egesten
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background and aim: Allergic asthma is a complex inflammatory disease involving type 2 innate lymphoid cells, type 2 T helper cells, macrophages, and eosinophils. The disease is characterized by wheezing, dyspnea, coughing, chest tightness and variab
Externí odkaz:
https://doaj.org/article/f6fed02054d74206a115008f6a48c7fb
Autor:
Rongrong Wu, Johan Högberg, Mikael Adner, Patricia Ramos-Ramírez, Ulla Stenius, Huiyuan Zheng
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-20 (2020)
Abstract Background Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be av
Externí odkaz:
https://doaj.org/article/d0789f7837814d5ea9ebf37cbefd0644
Autor:
Elin Rönnberg, Daryl Zhong Hao Boey, Avinash Ravindran, Jesper Säfholm, Ann-Charlotte Orre, Mamdoh Al-Ameri, Mikael Adner, Sven-Erik Dahlén, Joakim S. Dahlin, Gunnar Nilsson
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified. However, a systematic and comprehensive analysis o
Externí odkaz:
https://doaj.org/article/70038e9c3098457bbeea80ed423faa72
Autor:
Karlhans F. Che, Magnus Paulsson, Krzysztof Piersiala, Jakob Sax, Ibrahim Mboob, Mizanur Rahman, Rokeya S. Rekha, Jesper Säfholm, Mikael Adner, Peter Bergman, Lars-Olaf Cardell, Kristian Riesbeck, Anders Lindén
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pneumonia is a global cause of mortality, and this provides a strong incentive to improve the mechanistic understanding of innate immune responses in the lungs. Here, we characterized the involvement of the cytokine interleukin (IL)-26 in bacterial l
Externí odkaz:
https://doaj.org/article/6dc8ba69863248a08e7fa9febc854285
Autor:
Patricia Ramos-Ramírez, Carina Malmhäll, Kristina Johansson, Mikael Adner, Jan Lötvall, Apostolos Bossios
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8990 (2020)
Regulatory T cells (Tregs) decrease in the adipose tissue upon weight gain, contributing to persistent low-grade inflammation in obesity. We previously showed that adipose tissue Tregs express the adiponectin receptor 1 (AdipoR1); however, the expres
Externí odkaz:
https://doaj.org/article/76805d30ce6d4a9189c6c08d2531a86b
Autor:
Avinash Ravindran, Elin Rönnberg, Joakim S. Dahlin, Luca Mazzurana, Jesper Säfholm, Ann-Charlotte Orre, Mamdoh Al-Ameri, Peter Peachell, Mikael Adner, Sven-Erik Dahlén, Jenny Mjösberg, Gunnar Nilsson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: Mast cells are tissue-resident inflammatory cells defined by their high granularity and surface expression of the high-affinity IgE receptor, FcεRI, and CD117/KIT, the receptor for stem cell factor (SCF). There is a considerable heteroge
Externí odkaz:
https://doaj.org/article/8c507acbb30c4ccb9df6fe19832df12b