Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Mikael Altun"'
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 2143-2155 (2024)
Abstract Background Sarcopenia is an age‐related muscle disease that increases the risk of falls, disabilities, and death. It is associated with increased muscle protein degradation driven by molecular signalling pathways including Akt and FOXO1. T
Externí odkaz:
https://doaj.org/article/051892ee490c476aad67672bf9ce9175
Autor:
Alen Lovrić, Ali Rassolie, Seher Alam, Mirko Mandić, Amarjit Saini, Mikael Altun, Rodrigo Fernandez-Gonzalo, Thomas Gustafsson, Eric Rullman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Single-cell RNA-sequencing of human skeletal muscle before and after exercise highlights how physical activity changes the composition and transcriptomic profile of muscle tissue.
Externí odkaz:
https://doaj.org/article/12b483126ba740e2933231ce4d0eaad8
Autor:
Max GrönholdtKlein, Ali Gorzi, Lingzhan Wang, Erik Edström, Eric Rullman, Mikael Altun, Brun Ulfhake
Publikováno v:
Biology, Vol 12, Iss 9, p 1177 (2023)
The facultative loss of muscle mass and function during aging (sarcopenia) poses a serious threat to our independence and health. When activities of daily living are impaired (clinical phase), it appears that the processes leading to sarcopenia have
Externí odkaz:
https://doaj.org/article/51a22a2077f24a95a4a711d6bdc3cbc3
Autor:
Tatiana A. Giovannucci, Florian A. Salomons, Martin Haraldsson, Lotta H. M. Elfman, Malin Wickström, Patrick Young, Thomas Lundbäck, Jürgen Eirich, Mikael Altun, Rozbeh Jafari, Anna-Lena Gustavsson, John Inge Johnsen, Nico P. Dantuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-19 (2021)
Abstract Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery
Externí odkaz:
https://doaj.org/article/40038c990d214b6aae378be5f01e4f1b
Autor:
Amarjit Saini, Linda Björkhem-Bergman, Johan Boström, Mats Lilja, Michael Melin, Karl Olsson, Lena Ekström, Peter Bergman, Mikael Altun, Eric Rullman, Thomas Gustafsson
Publikováno v:
Endocrine Connections, Vol 8, Iss 7, Pp 1070-1081 (2019)
The CC genotype of the vitamin D receptor (VDR) polymorphism TaqI rs731236 has previously been associated with a higher risk of developing myopathy compared to TT carriers. However, the mechanistic role of this polymorphism in skeletal muscle is not
Externí odkaz:
https://doaj.org/article/fff6b049a28d4ee9a513d4753a1e2cee
Autor:
Yaser Heshmati, Shabnam Kharazi, Gözde Türköz, David Chang, Esmat Kamali Dolatabadi, Johan Boström, Aleksandra Krstic, Theodora Boukoura, Emma Wagner, Nadir Kadri, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Nucleosome assembly proteins (NAPs) are histone chaperones with an important role in chromatin structure and epigenetic regulation of gene expression. We find that high gene expression levels of mouse Nap1l3 are restricted to haematopoietic
Externí odkaz:
https://doaj.org/article/e85ae0005d43458ea0e54cc10c6d246f
Autor:
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3407-3416 (2016)
Externí odkaz:
https://doaj.org/article/358a7d08f38141fcb0e96d5b50776480
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia
Autor:
Yaser Heshmati, Gözde Türköz, Aditya Harisankar, Shabnam Kharazi, Johan Boström, Esmat Kamali Dolatabadi, Aleksandra Krstic, David Chang, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson
Publikováno v:
Haematologica, Vol 103, Iss 7 (2018)
Epigenetic alterations contribute to leukemogenesis in childhood acute myeloid leukemia and therefore are of interest for potential therapeutic strategies. Herein, we performed large-scale ribonucleic acid interference screens using small hairpin rib
Externí odkaz:
https://doaj.org/article/cc6b447b39d24e4fbc3b87c92511e42e
Autor:
Nicholas C.K. Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Azita Rasti, Marie-France Langelier, Daniel Rehling, Adam Throup, Matthieu Desroses, Prasad Wakchaure, Ingrid Almlöf, Seher Alam, Johan Boström, Luka Bevc, Pål Stenmark, John M. Pascal, Thomas Helleday, Brent D.G. Page, Mikael Altun
Cellular target engagement technologies are reforming drug discovery by enabling quantification of intracellular drug binding; however, concomitant assessment of drug-associated phenotypes has proven challenging. We have developed cellular target eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f650866e5c8606bb3761b58216ad109
https://doi.org/10.1101/2022.09.19.505646
https://doi.org/10.1101/2022.09.19.505646
Autor:
Yaser Heshmati, Gözde Türköz, Marios Dimitriou, Aditya Harisankar, Johan Boström, Huan Cai, Nadir Kadri, Mikael Altun, Hong Qian, Julian Walfridsson
Acute myeloid leukemia (AML) is an aggressive blood malignancy characterized by clonal accumulating of immature myeloid progenitors in the bone marrow and peripheral blood. Transcription factors are the most frequently mutated and dysregulated genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0d78cc204f4e74e20878efae8288a3
https://doi.org/10.1101/2022.08.09.503300
https://doi.org/10.1101/2022.08.09.503300