Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mikael, Sommarin"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
In the adult murine brain, neural stem cells (NSCs) can be found in two main niches: the dentate gyrus (DG) and the subventricular zone (SVZ). In the DG, NSCs produce intermediate progenitors (IPs) that differentiate into excitatory neurons, while pr
Externí odkaz:
https://doaj.org/article/658f183bf70346a79fc7199274d178db
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Autor:
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerbäck, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Böiers, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113357- (2023)
Externí odkaz:
https://doaj.org/article/afa99b9a000946b79b1053681bd6ceed
Autor:
Michael Bartoschek, Nikolay Oskolkov, Matteo Bocci, John Lövrot, Christer Larsson, Mikael Sommarin, Chris D. Madsen, David Lindgren, Gyula Pekar, Göran Karlsson, Markus Ringnér, Jonas Bergh, Åsa Björklund, Kristian Pietras
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putative
Externí odkaz:
https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
Autor:
Barbora Michaliková, Mikael Sommarin, Leif Bjermer, Sofia C Wijk, Sandra Lindstedt, Gunilla Westergren Thorsson, Nicholas D. Leigh, Karina Kanzenbach, Mattias Magnusson, Alexander Doyle, Stefan Lang, Ellen Tufvesson, Pavan Prabhala, Göran Karlsson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:103-113
Airway basal cells are crucial for regeneration of the human lung airway epithelium, and are thought to be important contributors to Chronic Obstructive Pulmonary Disease (COPD) and other lung disorders. In order to reveal how basal cells contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb302dba9231e7e1e14a3a3e7aa5d6f
https://doi.org/10.1165/rcmb.2020-0464oc
https://doi.org/10.1165/rcmb.2020-0464oc
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Developmental hematopoiesis differs from adult and is far less described. In the developing embryo, waves of lineage-restricted blood precede the ultimate emergence of definitive hematopoietic stem cells (dHSCs) capable of maintaining hematopoiesis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae71a77cbe4b33db11004dc27fd4770
https://doi.org/10.3389/fcell.2021.660350
https://doi.org/10.3389/fcell.2021.660350
Autor:
Mikael Sommarin, Fatemeh Safi, Konturek-Ciesla A, Parashar Dhapola, Eva Erlandsson, Geironson Ulfsson L, Charlotta Böiers, Rebecca Warfvinge, Göran Karlsson, Krishna Thakur R, David Bryder
The advent of single cell (Sc) genomics has challenged the dogma of haematopoiesis as a tree-like structure of stepwise lineage commitment through distinct and increasingly restricted progenitor populations. Instead, analysis of ScRNA-seq has propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7efbf6a5703db2c765dd7d7d8fe2263d
https://doi.org/10.1101/2021.04.01.437998
https://doi.org/10.1101/2021.04.01.437998
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Autor:
Fatemeh, Safi, Parashar, Dhapola, Sarah, Warsi, Mikael, Sommarin, Eva, Erlandsson, Jonas, Ungerbäck, Rebecca, Warfvinge, Ewa, Sitnicka, David, Bryder, Charlotta, Böiers, Ram Krishna, Thakur, Göran, Karlsson
Publikováno v:
Cell Reports. 39:110798
The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae97807473e6fdc3d3e0ba76dce5a24c
https://doi.org/10.1016/j.celrep.2022.110798
https://doi.org/10.1016/j.celrep.2022.110798
Autor:
Sofie Singbrant, Angel Raya, Julian Pulecio, Kavitha Siva, Mikael Sommarin, Vijay G. Sankaran, Kishori Dhulipala, Göran Karlsson, Carl R. Walkley, Shamit Soneji, Johan Flygare, Violeta Rayon-Estrada, Sandra Capellera-Garcia
Publikováno v:
Cell Reports
Cell Reports, Vol 15, Iss 11, Pp 2550-2562 (2016)
Cell Reports, Vol 15, Iss 11, Pp 2550-2562 (2016)
Summary Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary for instructing red bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e41d826cbe4d9f550436b11d5ee1537
Publikováno v:
J Vis Exp
Immunophenotypic characterization and molecular analysis have long been used to delineate heterogeneity and define distinct cell populations. FACS is inherently a single-cell assay, however prior to molecular analysis, the target cells are often pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c49aa28d6e60a8b17bdf8120f80981
https://doi.org/10.3791/57831-v
https://doi.org/10.3791/57831-v
Autor:
Jonas Bergh, John Lövrot, Gyula Pekar, Matteo Bocci, David Lindgren, Chris D. Madsen, Nikolay Oskolkov, Åsa K. Björklund, Christer Larsson, Michael Bartoschek, Mikael Sommarin, Kristian Pietras, Göran Karlsson, Markus Ringnér
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, although their origin and roles in shaping disease initiation, progression and treatment response remain unclear due to significant heterogeneity. Here, follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eefd791560baf968d47a8345015be1
https://pubmed.ncbi.nlm.nih.gov/30514914
https://pubmed.ncbi.nlm.nih.gov/30514914