Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mikael, Lerner"'
Autor:
Li-Di Xu, Susanne Muller, Srinivasan R Thoppe, Fredrik Hellborg, Lena Kanter, Mikael Lerner, Biying Zheng, Svetlana Bajalica Lagercrantz, Dan Grandér, Keng Ling Wallin, Klas G Wiman, Catharina Larsson, Sonia Andersson
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111125 (2014)
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and the encoded Wig-1 protein in cervical carcinoma cell lines and
Externí odkaz:
https://doaj.org/article/1f54762391aa457bab09cefad0d5a8ab
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36490 (2012)
The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains re
Externí odkaz:
https://doaj.org/article/4dfc994a34b447d2a6d93e85cad02658
Autor:
Jenny Viklund, Matheus Dyczynski, Henric Zazzi, Mikael Lerner, Katja Pokrovskaja Tamm, Tiago Braga, Angelo De Milito, Aine Brigette Henley, Magdalena Otrocka, Krister Wennerberg, Yasmin Yu, Santiago Parpal, Jessica Martinsson, Dan Grandér
Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408bc40ab04c91f0f31b34489b6c6cc8
http://hdl.handle.net/10138/238349
http://hdl.handle.net/10138/238349
Autor:
Stefan Grotegut, Daniel Klevebring, Helen Nilsson, Dahui Sun, Sanjay Navani, Fredrik Pontén, Karin Jirström, Juha Rantala, Mikael Lerner, Michael L. Nielsen, Kristina Magnusson, Vanessa Soto Cerrato, Mathias Uhlén, Salah Mahmoudi, Aldwin Suryo Rahmanto, Martin Widschwendter, Charles Spruck, Francesc Viñals, Cristina Al-Khalili Szigyarto, Erik Fredlund, Hamid Sharifi, Dan Grandér, James A. Wohlschlegel, Diana Cepeda, Nimesh Bhaskaran, Lars-Gunnar Larsson, Olle Sangfelt, Siti Mariam Zakaria, Hwee-Fang Ng, Alena Malyukova
Publikováno v:
EMBO Molecular Medicine. 5:1067-1086
SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by n
Autor:
Alexei Protopopov, Moshe E. Gatt, Daniel E. Carrasco, Bart Barlogie, Daniel R. Carrasco, John D. Shaughnessy, Teru Hideshima, Olle Sangfelt, Elena Ivanova, Kohichi Takada, Mala Mani, Dan Grandér, Kenneth C. Anderson, Mikael Lerner, Marjorie Pick
Publikováno v:
British Journal of Haematology. 162:210-220
Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). MM is characterized frequently by a complete or partial deletion of chromosome 13q14, seen in more than 50% of patients at diagn
Autor:
Mikael Lerner, Marianne Hammarsund, Monika Jansson, Martin Corcoran, Olle Sangfelt, Stefan Einhorn, Chaoyong Zhu, Mats Merup, Dan Grandér, Gösta Gahrton, Hanneke C. Kluin-Nelemans
Publikováno v:
Human Molecular Genetics, 13(23), 2925-2936. Oxford University Press
Karyotypical alteration of chromosome 5 and in particular band 5q13 is a frequent finding in hairy cell leukemia (HCL). We have previously identified a number of candidate genes localized in close proximity to a constitutional inv(5)(p13.1q13.3) brea
Autor:
Martin Corcoran, Olle Sangfelt, Mikael Lerner, Dan Grandér, Marianne Hammarsund, Lars Forsberg, Chaoyong Zhu, Rachel E. Ibbotson, Kapanadze Bi, Stefan Einhorn, Catharina Larsson, David Oscier, Bill Wilson
Publikováno v:
Genes, Chromosomes and Cancer. 40:285-297
Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no specific inactivating mutations were found in these or other genes in the vicinity of the deletion
Autor:
Mikael Lerner, Masako Harada, Olle Sangfelt, Zadie Davis, Jakob Lovén, Marie Henriksson, Juan Castro, David Oscier, Dan Grandér, Martin Corcoran
Publikováno v:
Experimental cell research. 315(17)
The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of m
Autor:
Roman A. Zubarev, Sophia Hober, Michael L. Nielsen, Mathias Uhlén, Diana Cepeda, Fredrik Pontén, Mikael Lerner, Dan Grandér, Martin Corcoran, Olle Sangfelt
RFP2, a gene frequently lost in various malignancies, encodes a protein with RING finger, B-box, and coiled-coil domains that belongs to the RBCC/TRIM family of proteins. Here we demonstrate that Rfp2 is an unstable protein with auto-polyubiquitinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3a6098eda9b1f634b3ea534aab77b5
https://europepmc.org/articles/PMC1855009/
https://europepmc.org/articles/PMC1855009/
Autor:
Sonia Andersson, Li-Di Xu, Biying Zheng, Srinivasan R. Thoppe, Fredrik Hellborg, Lena Kanter, Susanne Muller, Catharina Larsson, Mikael Lerner, Dan Grandér, Svetlana Lagercrantz, Klas G. Wiman, Keng-Ling Wallin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e111125 (2014)
PLoS ONE, Vol 9, Iss 11, p e111125 (2014)
The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and the encoded Wig-1 protein in cervical carcinoma cell lines and