Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mika Yokoyama"'
Autor:
Gensuke Takayama, Keiko Matsumoto, Tomoe Taira, Misato Aonuma, Mika Yokoyama, Yutaka Iigo, Tohru Takashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 2, Pp 172-175 (2013)
We investigated in vivo efficacies of the newly synthesized VLA-4 antagonist Compound A {trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid} on Ascaris antigen–
Externí odkaz:
https://doaj.org/article/824710aeb6d54d2f8b2ababbba6efc97
Autor:
Tsuyoshi Nakamura, Mika Yokoyama, Mayuko Akiu, Takashi Tsuji, Kouki Iida, Ken Sakurai, Yoshitaka Sogawa, Koji Terayama, Tomohiro Honda, Jun Tanaka, Daigo Asano, Anthony B. Pinkerton
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:1110-1122
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the nicotinamide adenine dinucleotide (NAD+) salvage pathway. Because NAD+ plays a pivotal role in energy metabolism and boosting NAD+ has positive effects on metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1559d4d089014d0c71e8a23a236697a9
https://doi.org/10.1248/cpb.c21-00700
https://doi.org/10.1248/cpb.c21-00700
Autor:
Kaori Tsutsumi, Utayo Nakaya, Yuta Koshino, Mari Tateno, Kazuhisa Matsumoto, Mai Tanaka, Mika Yokoyama, Tatsunori Horie, Mina Samukawa, Tamotsu Kamishima, Harukazu Tohyama
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 19; Issue 4; Pages: 2367
This study was conducted to measured talar displacement using ultrasound during an anterior drawer test (ADT) with a Telos device. Five adults (3 men and 2 women; 8 ankles; mean age: 23.2 y) with a history of ankle sprain and eight adults (5 men and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea2e34f8a16086b332fd62b59a1c19f
Autor:
Hideki Terashima, Misato Aonuma, Mikio Kato, Hiroshi Tsuchida, Kotaro Sugimoto, Mika Yokoyama
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 54:31-38
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease, and consequently, effective antifibrotic drugs are strongly desired. Although we have previously reported a validated Col1a1-Luc Tg rat model for fibrosis, there are only a few m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8212c8f11318cbd7fef79a6ebd743e9a
https://doi.org/10.1016/j.pupt.2018.11.005
https://doi.org/10.1016/j.pupt.2018.11.005
Autor:
Kazuhisa Matsumoto, Mai Tanaka, Mika Yokoyama, Tamotsu Kamishima, Utayo Nakaya, Tatsunori Horie, Kaori Tsutsumi, Mina Samukawa, Mari Tateno, Yuta Koshino, Harukazu Tohyama
Background Conventionally, X-ray examination has been performed to quantify the instability of the ankle joint. The aim of this study was to evaluate the reliability and validity of a new ultrasound-based examination for the quantitative detection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3a46bf85803657213dcc8e78aa13a15
https://doi.org/10.21203/rs.3.rs-129426/v1
https://doi.org/10.21203/rs.3.rs-129426/v1
Autor:
Mayuko Akiu, Takashi Tsuji, Yoshitaka Sogawa, Koji Terayama, Mika Yokoyama, Daigo Asano, Tomohiro Honda, Tomomichi Ishizaka, Tomoko Hasegawa, Anthony B. Pinkerton, Tsuyoshi Nakamura
Publikováno v:
HETEROCYCLES. 104:94
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d04af8f16133d0aaef6c447d4bbfefd9
https://doi.org/10.3987/com-21-14559
https://doi.org/10.3987/com-21-14559
Autor:
Jun Tanaka, Daigo Asano, E. Hampton Sessions, Koji Terayama, Mika Yokoyama, Mayuko Akiu, Takashi Tsuji, Ken Sakurai, Stephen J. Gardell, Yoshitaka Sogawa, Anthony B. Pinkerton, Eduard Sergienko, Tsuyoshi Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 43:128048
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD+ salvage pathway. Since NAD+ plays a pivotal role in many biological processes including metabolism and aging, activation of NAMPT is an attractive therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab9a198b4704738f4a9ffe0b2780ffe
https://doi.org/10.1016/j.bmcl.2021.128048
https://doi.org/10.1016/j.bmcl.2021.128048
Autor:
Atsushi Nakayama, Yutaka Iigo, Jun Chiba, Masaki Setoguchi, Yoshiyuki Yoneda, Shin Iimura, Tohru Takashi, Mika Yokoyama, Toshiyuki Watanabe, Misato Aonuma, Gensuke Takayama, Fumihito Muro, Yuuichi Sugimoto, Tomoe Taira, Nobuo Machinaga
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:42-61
We have carried out the optimization of substituents at the C-3 or the C-5 position on the pyrrolidine ring of VLA-4 antagonist 3 with 2-(phenylamino)-7-fluorobenzoxazolyl moiety for the purpose of improving in vivo efficacy while maintaining good aq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b010b5c8cdf32b434731e1e8a9598795
https://doi.org/10.1016/j.bmc.2012.11.003
https://doi.org/10.1016/j.bmc.2012.11.003
Autor:
Tomoe Taira, Misato Aonuma, Tohru Takashi, Mika Yokoyama, Jun Chiba, Toshiyuki Watanabe, Gensuke Takayama, Yuuichi Sugimoto, Yoshiyuki Yoneda, Masaki Setoguchi, Yutaka Iigo, Fumihito Muro, Atsushi Nakayama, Shin Iimura, Nobuo Machinaga
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1201-1212
For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N'-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc4465c69df773aa2a0bc445fc0a29f
https://doi.org/10.1016/j.bmc.2011.12.045
https://doi.org/10.1016/j.bmc.2011.12.045
Autor:
Masayuki Ishizaki, Kazuya Shimoda, Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda, Mika Yokoyama, Yuichi Sekine, Toshihiko Akimoto, Hiroaki Maeda, Yuya Ohshiro
Publikováno v:
The Journal of Immunology. 187:181-189
Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a8e453c71a127f846add27afa402d3
https://doi.org/10.4049/jimmunol.1003244
https://doi.org/10.4049/jimmunol.1003244