Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mika Tsujita"'
Autor:
Tetsuhiko Ikeda, Tetsuya Takahashi, Mika Tsujita, Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Kosuke Itoh, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128844 (2015)
Hypoglycemic encephalopathy (HE) is caused by a lack of glucose availability to neuronal cells, and no neuroprotective drugs have been developed as yet. Studies on the pathogenesis of HE and the development of new neuroprotective drugs have been cond
Externí odkaz:
https://doaj.org/article/1a4774b998eb4d68b28a293b281a845d
Publikováno v:
Neuroreport
Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water flux through the pericapillary (Virchow–Robin) space for both CSF production and reabsorption (Oreskovic and Klarica hypothesis), and challenge the classic CS
Autor:
Yukihiro Nakamura, Mika Tsujita, Yuji Suzuki, Kenichi Yamada, Vincent J. Huber, Tsutomu Nakada
Publikováno v:
Journal of Neuroimaging. 23:219-223
BACKGROUND AND PURPOSE Aquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP
Autor:
Vincent J. Huber, Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Mika Tsujita, Tsutomu Nakada
Publikováno v:
ACS Chemical Neuroscience
Aquaporin 4 (AQP4), the most abundant isozyme of the water specific membrane transporter aquaporin family, has now been implicated to play a significant role in the pathogenesis of various disease processes of the nervous system from epilepsy to Alzh
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
Autor:
Michihiro Igarashi, Kosei Takeuchi, Minesuke Yokoyama, Shiro Ikegawa, Yumi Watanabe, Susumu Higa Onaga, Michiko Sato, Norio Amizuka, Hiroshi Kitagawa, Tatsuya Furuichi, Rie Natsume, Tomomi Izumikawa, Ayumi Hasegawa, Mika Tsujita, Mika Saeki, Minqi Li, Kenji Sakimura, Manabu Abe
Publikováno v:
Biochemical Journal
CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)
Autor:
Makoto Itakura, Kouichi Hashimoto, Rie Natsume, Masanobu Kano, Masami Takahashi, Masahiro Fukaya, Kenji Sakimura, Miwako Yamasaki, Maya Yamazaki, Manabu Abe, Masahiko Watanabe, Mika Tsujita
Publikováno v:
European Journal of Neuroscience. 31:2204-2220
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors require auxiliary subunits termed transmembrane AMPA receptor regulatory proteins (TARPs), which promote receptor trafficking to the cell surface and synapse
Autor:
Masatoyo Nishizawa, Takashi Tani, Mika Tsujita, Tsutomu Nakada, Kenji Sakimura, Masami Tanaka, Keiko Tanaka
Publikováno v:
Journal of Neuroimmunology. 211:110-113
Objective Anti-aquaporin 4 antibodies (AQP4-Ab) are specifically detected in patients with neuromyelitis optica. To investigate the role of AQP4-Ab, we examined the antibody binding epitope using human and mouse mutant AQP4. Methods We constructed hu
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:411-417
The in vitro inhibitory effects and in silico docking energies of 18 compounds with respect to aquaporin 4 (AQP4) were investigated. More than half of the compounds tested showed inhibitory activity in the in vitro functional assay and included the 5
Publikováno v:
Anesthesiology. 106:1177-1185
Background T-type calcium channels regulate neuronal membrane excitability and participate in a number of physiologic and pathologic processes in the central nervous system, including sleep and epileptic activity. Volatile anesthetics inhibit native
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1270-1273
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 again