Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mika Senuma"'
Autor:
Takayuki Kumamoto, Tetsuo Ogawa, Reiko Suzuki, Fumiaki Kumagai, Mika Senuma, Makiko Kuwagata, Hajime Imai, Mai Todoroki
Publikováno v:
Fundamental Toxicological Sciences. 7:97-103
Publikováno v:
Congenital Anomalies. 59:190-192
Thoracolumbar supernumerary ribs (TSRs) are classified as less severe skeletal anomalies in rat developmental toxicity studies, although their incidence is relatively high in rodent studies. To investigate the characteristics of the critical window f
Autor:
Kumiko Ogawa, Kohei Matsushita, Young-Man Cho, Shigehiro Tachibana, Jun-ichi Akagi, Mika Senuma, Takeshi Toyoda
Publikováno v:
Journal of Toxicologic Pathology
Hexyl acetate (CAS No. 142-92-7) is a naturally occurring ester compound that has a fruity odor. Despite its frequent use as a nature-identical flavoring agent, there are limited repeated dose toxicity data for hexyl acetate. Here we performed a 13-w
Autor:
Shimpei Kajita, Kanata Ibi, Hiromasa Takashima, Toshiki Matsuoka, Yumi Sakai, Yoji Miwa, Mika Senuma, Tohru Uesugi, Masao Horimoto, Tatsuya Shimizu, Michio Fujiwara, Ken-ichi Noritake, Shino Nishizawa, Takayuki Hirano, Makiko Kuwagata, Masayuki Ube, Akihito Yamashita, Yuka Kirihata, Taishi Tateishi, Satoshi Kudo, Ryu-ichi Katagiri, Kaoru Yabe, Sho Tanaka, Takafumi Oota, Hitoshi Hojo, Nao Nakano, Terumasa Taniguchi, Yuko Sakai, Makoto Ema, Hiroshi Mineshima
Publikováno v:
Congenital anomalies. 59(4)
Historical control data from prenatal developmental toxicity studies in rats have been used to evaluate whether toxicology outcomes were induced by exposure to a chemical or were within the range of spontaneous variation. These data are also importan
Publikováno v:
International Journal of Developmental Neuroscience. 38:204-212
Prenatal arsenite exposure has been associated with developmental disorders in children, including reduced IQ and language abnormalities. Animal experiments have also shown that exposure to arsenite during development induced developmental neurotoxic
Autor:
Hiromasa Takashima, Atsushi Ono, Akihiko Hirose, Kazuhito Yokoyama, Mutsuko Hirata-Koizumi, Mariko Matsumoto, Makiko Yamaguchi, Hina Kato, Yuka Yoshida, Tomoko Kawamura, Mika Takahashi, Mika Senuma
Publikováno v:
Food and Chemical Toxicology. 56:290-296
A 28-day repeated dose toxicity test and reproduction/developmental toxicity test for N,N'-diphenyl-p-phenylenediamine (DPPD) were conducted in [Crl:CD(SD)] SPF rats. Male and female rats were dosed with DPPD by gavage for 28 days at 0, 100, 300, or
Autor:
Shigeru Hisada, Hiromasa Takashima, Takashi Ikeda, Keiichi Ito, Yoji Miwa, Mika Senuma, Ken-ichi Noritake, Eiji Maki, Taishi Tateishi
Publikováno v:
The Journal of Toxicological Sciences. 38:847-854
The purpose of the present study was to collect the background data on Wistar Hannover [Crl:WI(Han)] (hereafter Wistar Han) rats in embryo-fetal development studies from the 6 safety research facilities of pharmaceutical companies and contract resear
Autor:
Shinji Horiuchi, Mika Senuma, Takaho Watanabe, Hiromasa Takashima, Seishiro Hirano, Takashi Miyahara, Kenji Usumi, Naoyuki Hirabayashi, Yuji Fujitani, Syunji Yokota, Yuka Yoshida, Ryo Ohta, Hidekazu Fujimaki, Yoshiaki Saito, Tsukasa Negura
Publikováno v:
The Journal of Toxicological Sciences. 36:267-276
In the present study, in order to reveal novel adverse effects of ultrafine particles (UFP) on the central nervous system, the effects of nanoparticle-rich diesel exhaust particles (NRDEP; count mode diameter, 21.45 nm) on emotional behavior, learnin
Autor:
Hiroko Kubo, Chizu Wakai, Seiji Shioda, Mika Senuma, Makiko Kuwagata, Tetsuo Ogawa, Katsumasa Muneoka
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 30(6)
Neonatal brain function was investigated in a prenatal BrdU-induced developmental disorder model, which has been reported to exhibit behavioral abnormalities such as locomotor hyperactivity, impaired learning and memory, and lower anxiety in offsprin
Autor:
Syunji Yokota1 yokota.s@fdsc.or.jp, Hiromasa Takashima1, Ryo Ohta2, Yoshiaki Saito3, Takashi Miyahara1, Yuka Yoshida1, Tsukasa Negura1, Mika Senuma1, Kenji Usumi, Naoyuki Hirabayashi4, Takaho Watanabe4, Shinji Horiuchi5, Yuji Fujitani6, Seishiro Hirano6, Hidekazu Fujimaki6
Publikováno v:
Journal of Toxicological Sciences. Jun2011, Vol. 36 Issue 3, p267-276. 10p.