Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Mika Rämet"'
Autor:
Pinja Tissarinen, Heli Tiensuu, Antti M. Haapalainen, Eveliina Ronkainen, Liisa Laatio, Marja Vääräsmäki, Hanna Öhman, Mikko Hallman, Mika Rämet
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Currently, there are no accurate means to predict spontaneous preterm birth (SPTB). Recently, we observed low expression of alpha-1 antitrypsin (AAT) in SPTB placentas. Present aim was to compare the concentrations of maternal serum AAT in p
Externí odkaz:
https://doaj.org/article/bf2b0d178d8d43c3b6ecda17d5dda599
Autor:
Anu Pasanen, Minna K Karjalainen, FinnGen, Ge Zhang, Heli Tiensuu, Antti M Haapalainen, Marja Ojaniemi, Bjarke Feenstra, Bo Jacobsson, Aarno Palotie, Hannele Laivuori, Louis J Muglia, Mika Rämet, Mikko Hallman
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010982 (2023)
BackgroundPreterm birth (MethodsWe conducted a genome-wide meta-analysis of gestational duration and spontaneous preterm birth in 68,732 and 98,370 European mothers, respectively.ResultsThe meta-analysis detected 15 loci associated with gestational d
Externí odkaz:
https://doaj.org/article/f14300073a8b497a870ffbbe353c0e10
Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Autor:
Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Rämet
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-23 (2022)
Abstract Background Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely understood. Prediction a
Externí odkaz:
https://doaj.org/article/04242490e6fe48ffa80aef8110c60e46
Autor:
Anni K Saralahti, Sanna-Kaisa E Harjula, Tommi Rantapero, Meri I E Uusi-Mäkelä, Mikko Kaasinen, Maiju Junno, Hannaleena Piippo, Matti Nykter, Olli Lohi, Samuli Rounioja, Mataleena Parikka, Mika Rämet
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010586 (2023)
Streptococcus pneumoniae (pneumococcus) is one of the most frequent causes of pneumonia, sepsis and meningitis in humans, and an important cause of mortality among children and the elderly. We have previously reported the suitability of the zebrafish
Externí odkaz:
https://doaj.org/article/f53fb5fd72f74df4a0fa392e67b0badb
Autor:
Markus Knuf, Mika Rämet, Nina Breinholt Stærke, Isabelle Bertrand-Gerentes, Yaël Thollot, Siham B'Chir, Habiba Arroum, Philipp Oster
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
MenACYW-TT (MenQuadfi®) is a quadrivalent meningococcal tetanus toxoid conjugate vaccine licensed in Europe for use in individuals ≥12 months. This study assessed whether serogroup C immune responses with MenACYW-TT were at least non-inferior, or
Externí odkaz:
https://doaj.org/article/f8fdf994f438443daff54e11407cc4ab
Autor:
Johanna M. Huusko, Heli Tiensuu, Antti M. Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K. Karjalainen, Ge Zhang, Kaare Christensen, Kelli K. Ryckman, Bo Jacobsson, Jeffrey C. Murray, Stephen F. Kingsmore, Mikko Hallman, Louis J. Muglia, Mika Rämet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as m
Externí odkaz:
https://doaj.org/article/f305df8cd6b34e51b15c496289d931fa
Autor:
Mirva Järvelä-Stölting, Laura Vesala, Matthew K. Maasdorp, Joanna Ciantar, Mika Rämet, Susanna Valanne
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrom
Externí odkaz:
https://doaj.org/article/8c5cf89d2b9c4f7984be1c3fcab27f55
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Tuberculosis is a chronic infection by Mycobacterium tuberculosis that results in over 1.5 million deaths worldwide each year. Currently, there is only one vaccine against tuberculosis, the Bacillus Calmette–Guérin (BCG) vaccine. Despite widesprea
Externí odkaz:
https://doaj.org/article/58d3bb1b0303490ea4e46d02c98aab25
CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery.
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234403 (2020)
MicroRNAs (miRNAs) are important regulators of gene expression, and their expression is associated with many physiological conditions. Here, we investigated potential associations between expression levels of miRNAs in human placenta and the onset of
Externí odkaz:
https://doaj.org/article/1631a2db7ab94968adf0fcccbe28a54f
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Tuberculosis ranks as one of the world’s deadliest infectious diseases causing more than a million casualties annually. IL10 inhibits the function of Th1 type cells, and IL10 deficiency has been associated with an improved resistance again
Externí odkaz:
https://doaj.org/article/78c1723443f04eeab0de7d9debe41c41