Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mika Nagai"'
Autor:
Aiko Hasegawa, Shoji Saito, Shogo Narimatsu, Shigeru Nakano, Mika Nagai, Hideki Ohnota, Yoichi Inada, Hirokazu Morokawa, Ikumi Nakashima, Daisuke Morita, Yuichiro Ide, Kazuyuki Matsuda, Haruko Tashiro, Shigeki Yagyu, Miyuki Tanaka, Yozo Nakazawa
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 5, Pp n/a-n/a (2021)
Abstract Objectives As the prognosis of relapsed/refractory (R/R) acute myeloid leukaemia (AML) remains poor, novel treatment strategies are urgently needed. Clinical trials have shown that chimeric antigen receptor (CAR)‐T cells for AML are more c
Externí odkaz:
https://doaj.org/article/1425b53972624649b7548613523d6ce8
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2017 (2017)
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides. The purpose of the present study was to test whether PS2 mu
Externí odkaz:
https://doaj.org/article/4abd4f0423d8487dbbc9e7a964e1848e
Autor:
Narimatsu Shogo, Shoji Saito, Ikumi Nakashima, Daisuke Morita, Hirokazu Morokawa, Mika Nagai, Aiko Hasegawa, Yoichi Inada, Hideki Ohnota, Miyuki Tanaka, Kazuyuki Matsuda, Shigeru Nakano, Shigeki Yagyu, Haruko Tashiro, Yuichiro Ide, Yozo Nakazawa
Publikováno v:
Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 5, Pp n/a-n/a (2021)
Clinical & Translational Immunology, Vol 10, Iss 5, Pp n/a-n/a (2021)
Objectives As the prognosis of relapsed/refractory (R/R) acute myeloid leukaemia (AML) remains poor, novel treatment strategies are urgently needed. Clinical trials have shown that chimeric antigen receptor (CAR)‐T cells for AML are more challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed73a82fbffaa0a22e4ec68bf5347c2
https://pubmed.ncbi.nlm.nih.gov/33976880
https://pubmed.ncbi.nlm.nih.gov/33976880
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2479-2488
CYP2C enzymes play key roles in drug metabolism, and clinical drug-drug interactions caused by CYP2C induction have been reported. The aim of this study was to establish a method to predict the potency of CYP2C inductions considering the mechanism. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e52a376d7933745f6c02ac62c60bd3
https://doi.org/10.1016/j.xphs.2018.05.008
https://doi.org/10.1016/j.xphs.2018.05.008
Autor:
Hirokazu Morokawa, Yoichi Inada, Shoji Saito, Kazuyuki Matsuda, Ikumi Nakashima, Shigeki Yagyu, Miyuki Tanaka, Aiko Hasegawa, Yozo Nakazawa, Daisuke Morita, Yuichiro Ide, Haruko Tashiro, Mika Nagai
Publikováno v:
Blood. 136:36-37
Background: The prognosis of relapsed/refractory (R/R) acute myeloid leukemia (AML) remains poor; therefore, novel treatment strategies are required urgently. Meanwhile, recent clinical trials have demonstrated that CAR-T cells for AML have been less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11ef6633849b860946566eed36c721e8
https://doi.org/10.1182/blood-2020-134395
https://doi.org/10.1182/blood-2020-134395
Autor:
Kouichi Yoshinari, Mika Nagai
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 153(4)
Drug metabolism in the liver is a major factor affecting pharmacokinetics of drugs, and cytochrome P450s (P450s) are major enzymes responsible for it. Since drug-drug interactions (DDIs) can affect the pharmacokinetics of concomitantly administrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e52a692cf52d9a32b6807069ead729
https://pubmed.ncbi.nlm.nih.gov/30971659
https://pubmed.ncbi.nlm.nih.gov/30971659
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2017 (2017)
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role inγ-secretase-mediated cleavage of amyloid-βprecursor protein (APP) and the subsequent generation ofβ-amyloid peptides. The purpose of the present study was to test whether PS2 mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e109c8f657557f06a572ad1a78b6a8
https://doaj.org/article/4abd4f0423d8487dbbc9e7a964e1848e
https://doaj.org/article/4abd4f0423d8487dbbc9e7a964e1848e
Autor:
Mika Nagai, Kouichi Yoshinari
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S50-S51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d499fdc3aa911b393e535707fbee48d
https://doi.org/10.1016/j.dmpk.2017.11.174
https://doi.org/10.1016/j.dmpk.2017.11.174
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(8)
Drug-drug interactions (DDIs) via cytochrome P450 (P450) induction are one clinical problem leading to increased risk of adverse effects and the need for dosage adjustments and additional therapeutic monitoring. In silico models for predicting P450 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f625ec25e36615d203a99ce040d1e78b
https://pubmed.ncbi.nlm.nih.gov/27208383
https://pubmed.ncbi.nlm.nih.gov/27208383
Autor:
Hisatoshi Shida, Tominori Kimura, Yoshiyuki Hakata, Mika Nagai-Fukataki, Iwao Hashimoto, Takashi Ohashi
Publikováno v:
Genes to Cells. 16:203-216
The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Rev, mediates the nuclear export of unspliced gag and singly spliced env mRNAs by bridging viral RNA and the export receptor, CRM1. Recently, rat CRM1 was found to be less efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d68d06bd147dc204faf8ba36d96e39
https://doi.org/10.1111/j.1365-2443.2010.01476.x
https://doi.org/10.1111/j.1365-2443.2010.01476.x