Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mika Kosaka"'
Autor:
Faith Stevison, Mika Kosaka, Jane R. Kenny, Susan Wong, Cathryn Hogarth, John K. Amory, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 4, Pp 350-360 (2019)
All‐trans‐retinoic acid (atRA) downregulates cytochrome P450 (CYP)2D6 in several model systems. The aim of this study was to determine whether all active retinoids downregulate CYP2D6 and whether in vitro downregulation translates to in vivo drug
Externí odkaz:
https://doaj.org/article/b5acde5239844f1d9420489cbb1d82fb
Autor:
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory, Nina Isoherranen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(7)
Isotretinoin [13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ec1019807e64b2c80313286f3c89c4
https://pubmed.ncbi.nlm.nih.gov/35545255
https://pubmed.ncbi.nlm.nih.gov/35545255
Autor:
Cathryn A. Hogarth, John K. Amory, Susan Wong, Mika Kosaka, Faith Stevison, Nina Isoherranen, Jane R. Kenny
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 4, Pp 350-360 (2019)
Clinical and Translational Science
Clinical and Translational Science
All‐trans‐retinoic acid (at RA) downregulates cytochrome P450 (CYP)2D6 in several model systems. The aim of this study was to determine whether all active retinoids downregulate CYP2D6 and whether in vitro downregulation translates to in vivo dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9789888ece45d86d225ef22ef114837b
https://doi.org/10.1111/cts.12616
https://doi.org/10.1111/cts.12616
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(8)
Pyrrolo[2,1-c][1,4]benzodiazepine dimer (PBD) has shown broad antitumor properties and potential as a therapeutic agent for cancers. During a routine drug-drug interaction assessment, it was found that PBD is a reversible inhibitor of CYP2C8 (IC50 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5d70790ecc75f51c55b63723061f18
https://pubmed.ncbi.nlm.nih.gov/32482757
https://pubmed.ncbi.nlm.nih.gov/32482757
Autor:
Ning Liu, Mika Kosaka, Utkarsh Doshi, Jane R. Kenny, Albert P. Li, Peter Vuong, Suzanne Tay, Hoa Le, Susan Wong, Zhengyin Yan
Publikováno v:
Drug Metabolism Letters. 12:3-13
Background A recent advancement in isolation and cryopreservation has resulted in commercially available primary human enterocytes that express various drug metabolizing enzymes (DMEs) and transporters. The main objective of this study was to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19a9d3d789b2df64d293be5faba52dc
https://doi.org/10.2174/1872312812666171213114422
https://doi.org/10.2174/1872312812666171213114422
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S52-S53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af586fd34523330ddc63f19dff8a7d8
https://doi.org/10.1016/j.dmpk.2017.11.180
https://doi.org/10.1016/j.dmpk.2017.11.180
Autor:
Christopher Benner, Ronald M. Evans, Minna U. Kaikkonen, Michael T. Lam, Michael G. Rosenfeld, Sven Heinz, Cindy Y. Lee, Mika Kosaka, Hanna P. Lesch, Tamar R. Grossman, Aneeza Kim, Yumiko Tanaka-Oishi, Andrew T. Watt, David Gosselin, Han Cho, Christopher K. Glass
Publikováno v:
Nature. 498:511-515
Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting nuclear receptor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e413a1ce5683345a01eb1e7b1728a8
https://doi.org/10.1038/nature12209
https://doi.org/10.1038/nature12209
Publikováno v:
Nucleic Acid Therapeutics. 22:335-343
RNA activation (RNAa) is a mechanism of gene activation triggered by promoter-targeted small double-stranded RNA (dsRNA), also known as small activating RNA (saRNA). p21(WAF1/CIP1) (p21) is a putative tumor suppressor gene due to its role as a key ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efcdfd2c4b3422d848e082cb119112
https://doi.org/10.1089/nat.2012.0354
https://doi.org/10.1089/nat.2012.0354
Autor:
Ji, Wang, Robert F, Place, Victoria, Portnoy, Vera, Huang, Moo Rim, Kang, Mika, Kosaka, Maurice Kwok Chung, Ho, Long-Cheng, Li
Publikováno v:
Journal of Biological Methods, Vol 2, Iss 1, Pp e14-e14 (2015)
Vector-based systems comprised of exogenous nucleic acid sequences remain the standard for ectopic expression of a particular gene. Such systems offer robust overexpression, but have inherent drawbacks such the tedious process of construction, exclud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32de8ff8bb872408245a3ce008d300b1
http://www.jbmethods.org/jbm/article/view/39
http://www.jbmethods.org/jbm/article/view/39
Autor:
Mika Kosaka, Michael T. Lam, Cindy Y. Lee, Sven Heinz, Ronald M. Evans, Minna U. Kaikkonen, Christopher Benner, Christopher K. Glass, Yumiko Tanaka-Oishi, Han Cho
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52bff5bfb206d86f7bd2ebc4e34386a
https://doi.org/10.1096/fasebj.26.1_supplement.912.1
https://doi.org/10.1096/fasebj.26.1_supplement.912.1