Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Autor: Chandrika N. Deshpande, T. Alex Ruwe, Ali Shawki, Vicky Xin, Kyle R. Vieth, Erika V. Valore, Bo Qiao, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that

Externí odkaz: https://doaj.org/article/61dff6b0396e40ccba89522883e761ae

The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure.

Autor: Miriam-Rose Ash, Megan J Maher, J Mitchell Guss, Mika Jormakka

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23355 (2011)

The polytopic membrane protein FeoB is a ferrous iron transporter in prokaryotes. The protein contains a potassium-activated GTPase domain that is essential in regulating the import of iron and conferring virulence to many disease-causing bacteria. H

Externí odkaz: https://doaj.org/article/d6a64bc01e444eca91094a40eefaf10a

Isolation and thermal stabilization of mouse ferroportin

Autor: Bo Qiao, So Iwata, Chandrika N. Deshpande, Mika Jormakka, Norimichi Nomura, Elizabeta Nemeth, Josep Font, Bryan Mackenzie, Corbin R. Azucenas, Tomas Ganz, Vicky Xin

Publikováno v: FEBS Open Bio

Here, Deshpande et al. describe the production and purification of mouse ferroportin (Fpn), the only known mammalian iron efflux protein, and selective loop deletion constructs with enhanced thermal stability. Transport activity and hepcidin responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2120c07ef4b9f757eeed046c54cfe4
https://doi.org/10.1002/2211-5463.13039

Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Autor: Vicky Xin, T Alex Ruwe, Bryan Mackenzie, Kyle R. Vieth, Bo Qiao, Ali Shawki, Mika Jormakka, Chandrika N. Deshpande, Tomas Ganz, Erika V. Valore, Elizabeta Nemeth

Publikováno v: Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Deshpande, CN; Ruwe, TA; Shawki, A; Xin, V; Vieth, KR; Valore, EV; et al.(2018). Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-05446-4. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0wp7091s
Nature Communications

Ferroportin (Fpn)—the only known cellular iron exporter—transports dietary and recycled iron into the blood plasma, and transfers iron across the placenta. Despite its central role in iron metabolism, our molecular understanding of Fpn-mediated i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019374d32f398be01e118b12e65275cb
https://escholarship.org/uc/item/0wp7091s

Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

Autor: Rebecca H. Pouwer, John E.J. Rasko, Charles G. Bailey, Renae M. Ryan, Ronald J. Quinn, Josep Font, Anne M. Moran, Sarah Ann Bonham, Jeff Holst, Tanja Grkovic, Mika Jormakka, Qian Wang

Publikováno v: ACS Chemical Biology

The L-type amino acid transporter (LAT) family consists of four members (LAT1-4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6332fcf7f823c893444f634e397e6ac5
https://doi.org/10.1021/cb500120x