Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mika J. Välimäki"'
Autor:
Mikael Jumppanen, Sini M. Kinnunen, Matej Zore, Mika J. Välimäki, Virpi Talman, Gustav Boije af Gennäs, Heikki J. Ruskoaho, Jari Yli-Kauhaluoma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently no cure to prevent and reverse cardiac remodeling
Externí odkaz:
https://doaj.org/article/2029b729860d4650ad7fb8a5f2680938
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Autor:
Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific
Externí odkaz:
https://doaj.org/article/614c3e9ddc044f04a27581297b6207ab
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1869:166689
Autor:
Virpi Talman, Marja Tölli, Mika J. Välimäki, S. Tuuli Karhu, Sini Kinnunen, Zoltan Szabo, Heikki Ruskoaho
Publikováno v:
Archives of Toxicology
Doxorubicin is a widely used anticancer drug that causes dose-related cardiotoxicity. The exact mechanisms of doxorubicin toxicity are still unclear, partly because most in vitro studies have evaluated the effects of short-term high-dose doxorubicin
Publikováno v:
ACS Chemical Neuroscience
Neurodegenerative diseases are associated with failed proteostasis and accumulation of insoluble protein aggregates that compromise neuronal function and survival. In Parkinson's disease, a major pathological finding is Lewy bodies and neurites that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0684763fc40ff4bbc2755e9e0fcb3e72
http://hdl.handle.net/10138/332776
http://hdl.handle.net/10138/332776
Autor:
Heikki Ruskoaho, Mika J. Välimäki, Samuli Auno, Jari Yli-Kauhaluoma, Ingo B. Aumüller, Virpi Talman, Henri Xhaard, Gustav Boije af Gennäs, Sini Kinnunen, Tanja Bruun, Mikael Jumppanen
Publikováno v:
Journal of Medicinal Chemistry
Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the
Autor:
Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Iubmb Life
Various strategies have been applied to replace the loss of cardiomyocytes in order to restore reduced cardiac function and prevent the progression of heart disease. Intensive research efforts in the field of cellular reprogramming and cell transplan
Autor:
Gustav Boije af Gennäs, Lotta Pohjolainen, Jari Yli-Kauhaluoma, Robert S. Leigh, Virpi Talman, Mikael Jumppanen, Mika J. Välimäki, Gabor Foldes, Heikki Ruskoaho, Tuuli Karhu
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-9
Autor:
Gabor Foldes, Gustav Boije af Gennäs, Samuli Auno, Lotta Pohjolainen, Sini Kinnunen, Jari Yli-Kauhaluoma, Virpi Talman, Mikael Jumppanen, S. Tuuli Karhu, Mika J. Välimäki, Heikki Ruskoaho, Robert S. Leigh
Publikováno v:
Archives of Toxicology
Safety assessment of drug candidates in numerous in vitro and experimental animal models is expensive, time consuming and animal intensive. More thorough toxicity profiling already in the early drug discovery projects using human cell models, which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82948851bd15a94e2fddbdbd8b3787ca
http://hdl.handle.net/10138/240364
http://hdl.handle.net/10138/240364