Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Mika Ala-Korpela"'
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-9 (2024)
Abstract Background Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyon
Externí odkaz:
https://doaj.org/article/983a6c7b1a5a41d1b8fb838855775288
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract We assigned 329,908 UK Biobank participants into six subgroups based on a self-organizing map of 51 biochemical measures (blinded for clinical outcomes). The subgroup with the most favorable metabolic traits was chosen as the reference. Haza
Externí odkaz:
https://doaj.org/article/893d0e489ae54bad898b481b31b3c48d
Autor:
Saara Marttila, Suvi Rovio, Pashupati P. Mishra, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Markus Juonala, Melanie Waldenberger, Niku Oksala, Mika Ala-Korpela, Emily Harville, Nina Hutri-Kähönen, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Emma Raitoharju
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Preterm birth (PTB) is associated with increased risk of type 2 diabetes and neurocognitive impairment later in life. We analyzed for the first time the associations of PTB with blood miRNA levels in adulthood. We also investigated the relat
Externí odkaz:
https://doaj.org/article/d6935f0b93b346128975b23ece2111de
Autor:
Raimo Jauhiainen, Matti Jauhiainen, Jagadish Vangipurapu, Teemu Kuulasmaa, Mika Ala‐Korpela, Markku Laakso, Johanna Kuusisto
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 605-614 (2021)
Abstract Aims There are only a few studies on novel biomarkers for incident heart failure (HF). We investigated the association of multiple circulating biomarkers with incident HF in a large prospective population‐based study. Methods and results C
Externí odkaz:
https://doaj.org/article/e8d269afbcad43b4948b1e7cf3d9a979
Autor:
Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Lars Lind, Johan Ärnlöv, Bruno H. C. Stricker, Guy G. Brusselle, H. Marike Boezen, Cornelia M. van Duijn, Najaf Amin
Publikováno v:
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Chronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well as systemic changes. Metabolic changes in blood may help detect COPD in an earlier stage
Externí odkaz:
https://doaj.org/article/7713de2df3e641e195c822e4a3b8bf44
Autor:
Scott T. Chiesa, Marietta Charakida, Georgios Georgiopoulos, Justin D. Roberts, Simon J. Stafford, Chloe Park, Juha Mykkänen, Mika Kähönen, Terho Lehtimäki, Mika Ala‐Korpela, Olli Raitakari, Milla Pietiäinen, Pirkko Pussinen, Vivek Muthurangu, Alun D. Hughes, Naveed Sattar, Nicholas J. Timpson, John E. Deanfield
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 4 (2022)
Background Low‐grade inflammation in the young may contribute to the early development of cardiovascular disease. We assessed whether circulating levels of glycoprotein acetyls (GlycA) were better able to predict the development of adverse cardiova
Externí odkaz:
https://doaj.org/article/0aac8b599987442fa69aba6e405d172e
Autor:
Emmi Tikkanen, Vilma Jägerroos, Michael V. Holmes, Naveed Sattar, Mika Ala‐Korpela, Pekka Jousilahti, Annamari Lundqvist, Markus Perola, Veikko Salomaa, Peter Würtz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiologi
Externí odkaz:
https://doaj.org/article/dac13f26ed3f4657be68171482bb8f6f
Autor:
Tom G Richardson, PhD, Qin Wang, PhD, Eleanor Sanderson, PhD, Anubha Mahajan, PhD, Mark I McCarthy, ProfMD, Timothy M Frayling, ProfPhD, Mika Ala-Korpela, ProfPhD, Allan Sniderman, ProfMD, George Davey Smith, ProfFRS, Michael V Holmes, MD
Publikováno v:
The Lancet. Healthy Longevity, Vol 2, Iss 6, Pp e317-e326 (2021)
Summary: Background: Apolipoprotein B (apoB) is emerging as the crucial lipoprotein trait for the role of lipoprotein lipids in the aetiology of coronary heart disease. In this study, we evaluated the effects of genetically predicted apoB on outcomes
Externí odkaz:
https://doaj.org/article/bc63b18e9b274f27bdc502a9b153d18b
Autor:
Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen, Mika Ala-Korpela
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background Insulin resistance (IR) is predictive for type 2 diabetes and associated with various metabolic abnormalities in fasting conditions. However, limited data are available on how IR affects metabolic responses in a non-fasting settin
Externí odkaz:
https://doaj.org/article/688a9a1a0c4d4ef6ae58ea246ba3f7e0
Autor:
Apolline Gallois, Joel Mefford, Arthur Ko, Amaury Vaysse, Hanna Julienne, Mika Ala-Korpela, Markku Laakso, Noah Zaitlen, Päivi Pajukanta, Hugues Aschard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Genome-wide association studies of metabolites have revealed hundreds of genetic associations using univariate analyses. Here, the authors use a multivariate approach to perform association analyses for 158 serum metabolites, followed by fine mapping
Externí odkaz:
https://doaj.org/article/18f5d61c166a4f04bdb8979fa46f9cb9