Data from Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Autor: George Coukos, Melita Irving, Denarda Dangaj Laniti, Santiago J. Carmona, Lana E. Kandalaft, Alexandre Harari, Urania Dafni, Christine Sempoux, Stefan Zimmermann, Mikaël J. Pittet, Sylvie Rusakiewicz, Periklis Foukas, Sarah E. Warren, Thomas Smith, Marius Messemaker, Zoi Tsourti, Georgia Dimopoulou, Jean Bourhis, Niklaus Schaefer, John Prior, Clarisse Dromain, Rafael Duran, Khalil Zaman, Apostolos Sarivalasis, Dominik R. Berthold, Blanca Navarro Rodrigo, Eleonora Ghisoni, Martina Imbimbo, Angela Orcurto, Raphael Genolet, Fabrizio Benedetti, Aodrenn Spill, Jesus Corria-Osorio, Massimo Andreatta, Isaac Crespo, David Barras, Maria Ochoa de Olza, Catherine Ronet, Fernanda G. Herrera

Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42361d442a283c57e9ad86282f9855a8
https://doi.org/10.1158/2159-8290.c.6549407.v1

Supplementary Data from Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Autor: George Coukos, Melita Irving, Denarda Dangaj Laniti, Santiago J. Carmona, Lana E. Kandalaft, Alexandre Harari, Urania Dafni, Christine Sempoux, Stefan Zimmermann, Mikaël J. Pittet, Sylvie Rusakiewicz, Periklis Foukas, Sarah E. Warren, Thomas Smith, Marius Messemaker, Zoi Tsourti, Georgia Dimopoulou, Jean Bourhis, Niklaus Schaefer, John Prior, Clarisse Dromain, Rafael Duran, Khalil Zaman, Apostolos Sarivalasis, Dominik R. Berthold, Blanca Navarro Rodrigo, Eleonora Ghisoni, Martina Imbimbo, Angela Orcurto, Raphael Genolet, Fabrizio Benedetti, Aodrenn Spill, Jesus Corria-Osorio, Massimo Andreatta, Isaac Crespo, David Barras, Maria Ochoa de Olza, Catherine Ronet, Fernanda G. Herrera

Supplementary Data from Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc019e17ebcdfce120dec328cf67e5b
https://doi.org/10.1158/2159-8290.22540583.v1

Dendritic cells direct circadian anti-tumor immune responses

Autor: Chen Wang, Coline Barnoud, Mara Cenerenti, Mengzhu Sun, Irene Caffa, Burak Kizil, Ruben Bill, Yuanlong Liu, Robert Pick, Laure Garnier, Olga A. Gkountidi, Louise M. Ince, Stephan Holtkamp, Nadine Fournier, Olivier Michielin, Daniel E. Speiser, Stéphanie Hugues, Alessio Nencioni, Mikaël J. Pittet, Camilla Jandus, Christoph Scheiermann

Publikováno v: Wang, Chen; Barnoud, Coline; Cenerenti, Mara; Sun, Mengzhu; Caffa, Irene; Kizil, Burak; Bill, Ruben; Liu, Yuanlong; Pick, Robert; Garnier, Laure; Gkountidi, Olga A; Ince, Louise M; Holtkamp, Stephan; Fournier, Nadine; Michielin, Olivier; Speiser, Daniel E; Hugues, Stéphanie; Nencioni, Alessio; Pittet, Mikaël J; Jandus, Camilla; ... (2023). Dendritic cells direct circadian anti-tumor immune responses. Nature, 614(7946), pp. 136-143. Springer Nature 10.1038/s41586-022-05605-0

The process of cancer immunosurveillance is a mechanism of tumour suppression that can protect the host from cancer development throughout its lifetime1,2. However, it is unknown whether the effectiveness of cancer immunosurveillance fluctuates over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c5412fe0197711ec212feccd733e4
https://boris.unibe.ch/176997/1/s41586-022-05605-0_reference.pdf

Activation of human melanoma reactive CD8+ T cells by vaccination with an immunogenic peptide analog derived from Melan-A/melanoma antigen recognized by T cells-1

Autor: Maha, Ayyoub, Alfred, Zippelius, Mikaël J, Pittet, Donata, Rimoldi, Danila, Valmori, Jean-Charles, Cerottini, Pedro, Romero, Ferdy, Lejeune, Danielle, Liénard, Daniel E, Speiser

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(2)

As compared with natural tumor peptide sequences, carefully selected analog peptides may be more immunogenic and thus better suited for vaccination. However, T cells in vivo activated by such altered analog peptides may not necessarily be tumor speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6532c877fc5f8a0a2ef88d658ecf95f4
https://pubmed.ncbi.nlm.nih.gov/12576434

Pharmacological Polarization of Tumor‐Associated Macrophages Toward a CXCL9 Antitumor Phenotype.

Autor: Enbergs, Noah¹ (AUTHOR), Halabi, Elias A.¹ (AUTHOR), Goubet, Anne‐Gaëlle^2,3 (AUTHOR), Schleyer, Kelton¹ (AUTHOR), Fredrich, Ina R.¹ (AUTHOR), Kohler, Rainer H.¹ (AUTHOR), Garris, Christopher S.¹ (AUTHOR), Pittet, Mikaël J.^2,3,4 (AUTHOR), Weissleder, Ralph^1,5 (AUTHOR) rweissleder@mgh.harvard.edu

Publikováno v: Advanced Science. 4/17/2024, Vol. 11 Issue 15, p1-12. 12p.