Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Mika, Scheinin"'
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Patient recruitment for clinical trials is challenging—only approximately one third of all trials recruit their participants as planned. The pharmaceutical industry’s views on recruitment success have not been comprehensively
Externí odkaz:
https://doaj.org/article/f99e81dff8ef46068c2dcd83b1e1f004
Autor:
Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen, Juha Rouru
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Background Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain functi
Externí odkaz:
https://doaj.org/article/f2ab19aa502748819823cd5dec03a851
Autor:
Petri J. Vainio, Pauliina Hietasalo, Anna-Liisa Koivisto, Susanna Kääriäinen, Jari Turunen, Mika Virtala, Jouni Vuorinen, Mika Scheinin
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-3 (2021)
Abstract Objectives The primary objective of this study is to evaluate the therapeutic potential of hydroxychloroquine (HCQ) in the treatment of adult patients with PCR-confirmed Covid-19 infection in a primary open-care setting, as compared to place
Externí odkaz:
https://doaj.org/article/0cd899f104824b0797e9da1a987be223
Autor:
Donata Ponikwicka-Tyszko, Marcin Chrusciel, Joanna Stelmaszewska, Piotr Bernaczyk, Paulina Chrusciel, Maria Sztachelska, Mika Scheinin, Mariusz Bidzinski, Jacek Szamatowicz, Ilpo T. Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 170-183 (2019)
Background: Recent clinical trials on ovarian cancer with mifepristone (MF) have failed, despite in vitro findings on its strong progesterone (P4) antagonist function. Methods: Ovarian cancer human and murine cell lines, cultured high-grade human pri
Externí odkaz:
https://doaj.org/article/14f6ae924ff0434f8871c59b41acc703
Autor:
Panu Uusalo, Mirjam Lehtinen, Eliisa Löyttyniemi, Tuula Manner, Mika Scheinin, Teijo I. Saari
Publikováno v:
BMC Anesthesiology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Barbiturates are commonly used in ambulatory sedation of pediatric patients. However, use of barbiturates involve risks of respiratory complications. Dexmedetomidine, a highly selective α2-adrenoceptor agonist, is increasingly us
Externí odkaz:
https://doaj.org/article/96c4a5b4905448ae92b2c5b592976aad
Autor:
Niina Laaksonen, Juha-Matti Varjonen, Minna Blomster, Antti Palomäki, Tuija Vasankari, Juhani Airaksinen, Risto Huupponen, Mika Scheinin, Juuso Blomster
Publikováno v:
Contemporary Clinical Trials Communications, Vol 21, Iss , Pp 100692- (2021)
Electronic health records (EHR) are a potential resource for identification of clinical trial participants. We evaluated how accurately a commercially available EHR Research Platform, InSite, is able to identify potential trial participants from the
Externí odkaz:
https://doaj.org/article/4fb7c686a9394a0d8ed5bfb8a37a1e0a
Autor:
Outi Hälli, Minna Haimi-Hakala, Tapio Laurila, Claudio Oliviero, Elina Viitasaari, Toomas Orro, Olli Peltoniemi, Mika Scheinin, Saija Sirén, Anna Valros, Mari Heinonen
Publikováno v:
Porcine Health Management, Vol 4, Iss 1, Pp 1-14 (2018)
Abstract Background Infection with respiratory pathogens can influence production as well as animal welfare. There is an economical and ethical need to treat pigs that suffer from respiratory diseases. Our aim was the evaluation of the possible effec
Externí odkaz:
https://doaj.org/article/4327d47f4626445dba4e1d1ca39e4254
Publikováno v:
Nutrients, Vol 13, Iss 9, p 3189 (2021)
Nitrogen balance is the difference between nitrogen excreted as urea and nitrogen ingested, mainly in proteins. Increased circulating concentrations of amino acids (AA) in the bloodstream are usually associated with proportional increases in the prod
Externí odkaz:
https://doaj.org/article/a11fd8e5f6ca4b39b6cfc1b491275be6
Autor:
Maria Saarenhovi, Pia Salo, Mika Scheinin, Jussi Lehto, Zsófia Lovró, Kirsti Tiihonen, Markus J. Lehtinen, Jouni Junnila, Oliver Hasselwander, Anneli Tarpila, Olli T. Raitakari
Publikováno v:
Nutrition Journal, Vol 16, Iss 1, Pp 1-13 (2017)
Abstract Background The primary aim of this study was to test the hypothesis that an orally ingested apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers improves endothelium-dependent brachial artery flow-mediated vasodilatation (F
Externí odkaz:
https://doaj.org/article/3b4f9d71376b4972a659673d40a438db
Autor:
Sari Castrén, Niklas Mäkelä, Janne Haikola, Anne H Salonen, Roger Crystal, Mika Scheinin, Hannu Alho
Publikováno v:
BMJ Open, Vol 9, Iss 8 (2019)
Background and aim There is growing interest in the use of medication-assisted treatments for gambling disorder (GD). Opioid receptor antagonists are hypothesised to blunt the craving associated with gambling. This study was designed to assess the fe
Externí odkaz:
https://doaj.org/article/fd2b63bc74d245b6990ada465694ce24