Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Mika, Naganawa"'
Autor:
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD
Externí odkaz:
https://doaj.org/article/f8c1054730b44122933ba28992365acc
Autor:
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/122ac1a04cba45599d3bd6bbd84a5c1e
Autor:
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis, Richard E. Carson
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed faster entry into the hu
Externí odkaz:
https://doaj.org/article/22d2f1f3be124f3691b641c2f77893e1
Autor:
Ryan S. O'Dell, Albert Higgins-Chen, Dhruva Gupta, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Gessica Ni, Anna Chupak, Wenzhen Zhao, Elaheh Salardini, Nabeel B. Nabulsi, Yiyun Huang, Amy F.T. Arnsten, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
Publikováno v:
NeuroImage: Clinical, Vol 39, Iss , Pp 103457- (2023)
Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synapt
Externí odkaz:
https://doaj.org/article/14ed4c06b1984adc816314ca9ad18e33
Autor:
Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clini
Externí odkaz:
https://doaj.org/article/bf54db7ecf0047c889104bb1723e1147
Autor:
Enette Mae Revilla, Jean-Dominique Gallezot, Mika Naganawa, Takuya Toyonaga, Kathryn Fontaine, Tim Mulnix, John A. Onofrey, Richard E. Carson, Yihuan Lu
Publikováno v:
NeuroImage, Vol 252, Iss , Pp 119031- (2022)
Head motion during PET scans causes image quality degradation, decreased concentration in regions with high uptake and incorrect outcome measures from kinetic analysis of dynamic datasets. Previously, we proposed a data-driven method, center of trace
Externí odkaz:
https://doaj.org/article/11a6bb30414a40589477d9fb74705e4a
Autor:
Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118248- (2021)
Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the com
Externí odkaz:
https://doaj.org/article/1b130473ba4e412bbffdd545c6e6b04d
Autor:
Sophie E. Holmes, Dustin Scheinost, Sjoerd J. Finnema, Mika Naganawa, Margaret T. Davis, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Robert H. Pietrzak, Ronald S. Duman, Gerard Sanacora, John H. Krystal, Richard E. Carson, Irina Esterlis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is
Externí odkaz:
https://doaj.org/article/16df126356f84726bd48b72d3e90f6bf
Autor:
Jong H. Yoon, Zhener Zhang, Elizabeth Mormino, Guido Davidzon, Michael J. Minzenberg, Jacob Ballon, Agnieszka Kalinowski, Kate Hardy, Mika Naganawa, Richard E. Carson, Mehdi Khalighi, Jun Hyung Park, Douglas F. Levinson, Frederick T. Chin
Publikováno v:
Journal of Psychiatric Research. 161:213-217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eeed88f307f1bec80978f37a56c0a96
https://doi.org/10.1016/j.jpsychires.2023.02.026
https://doi.org/10.1016/j.jpsychires.2023.02.026
Autor:
Richard E, Carson, Mika, Naganawa, Takuya, Toyonaga, Sheida, Koohsari, Yanghong, Yang, Ming-Kai, Chen, David, Matuskey, Sjoerd J, Finnema
Publikováno v:
Journal of Nuclear Medicine. 63:60S-67S
PET technology has produced many radiopharmaceuticals that target specific brain proteins and other measures of brain function. Recently, a new approach has emerged to image synaptic density by targeting the synaptic vesicle protein 2A (SV2A), an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8c9dbdad70e69fc719d3ed48aed634
https://doi.org/10.2967/jnumed.121.263201
https://doi.org/10.2967/jnumed.121.263201