Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Mika, Murabayashi"'
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Development of a Practical Synthesis of a Peripherally Selective Noradrenaline Reuptake Inhibitor Possessing a Chiral 6,7-trans-Disubstituted-1,4-oxazepane as a Scaffold
Autor: Mika Murabayashi, Atsushi Nishimoto, Kazuhisa Ishimoto, Tomomi Ikemoto, Kotaro Yamaguchi
Publikováno v: Organic Process Research & Development. 21:2001-2011
A practical synthesis of a peripherally selective noradrenaline reuptake inhibitor that has a chiral 6,7-trans-disubstituted-1,4-oxazepane as a new class of scaffold is described. The amino alcohol possessing the desired stereochemistry was obtained
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a70f616564aa18a4989e21183cc7fdc
https://doi.org/10.1021/acs.oprd.7b00313
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7
Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers
Autor: Hidenori Kamiguchi, Akira Horinouchi, Kazutaka Higaki, Mika Murabayashi, Ikuo Mori
Publikováno v: Biomarkers. 22:178-188
Context: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool is highly desirable.Objective: The objective of this study is to explored novel biomarkers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dac2a5921928eebe2a0ac22705c503b
https://doi.org/10.1080/1354750x.2016.1252958
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8
Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Autor: Masashi Yamaguchi, Ikuo Mori, Mika Murabayashi, Hidenori Kamiguchi, Akira Horinouchi
Publikováno v: Journal of Chromatography B. 1035:76-83
Urinary hippuric acid (HA) and phenylacetylglycine (PAG) are biomarker candidates for drug-induced phospholipidosis (PLD). To confirm their utility in preclinical and clinical settings, it is essential to develop and validate their quantification met
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc28275915471704329408f89c412d09
https://doi.org/10.1016/j.jchromb.2016.09.036
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9
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives: a synthesis of [1,2,4]triazolo[1,5-a]pyridin-2-amines and an unexpected synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-amines
Autor: Toshiaki Nagata, Kazuhisa Ishimoto, Tomomi Ikemoto, Mika Murabayashi
Publikováno v: Tetrahedron. 71:407-418
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N -chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N -chlorosuccinimide in methanol followed by addition
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa1708fddbda053d98dc6e27d158966
https://doi.org/10.1016/j.tet.2014.12.015
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10
ChemInform Abstract: Oxidative Cyclization of 1-(Pyridin-2-yl)guanidine Derivatives: A Synthesis of [1,2,4]Triazolo[1,5-a]pyridin-2-amines and an Unexpected Synthesis of [1,2,4]Triazolo[4,3-a]pyridin-3-amines
Autor: Tomomi Ikemoto, Mika Murabayashi, Toshiaki Nagata, Kazuhisa Ishimoto
Publikováno v: ChemInform. 46
Oxidative cyclization of pyridinyl guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate gives the entitled triazolo[1,5-a]pyridin-2-amines in one-pot and, in some cases, also unexpected triazolo[4,3-a]pyridin-3-amine produc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdfe2a466f9bd95bb8a02d4e32657698
https://doi.org/10.1002/chin.201521160
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