Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Mika, Gustafsson"'
Autor:
Isabelle Öhrnberg, Lovisa Karlsson, Shumaila Sayyab, Jakob Paues, David Martínez-Enguita, Mika Gustafsson, Patricia Espinoza-Lopez, Melissa Méndez-Aranda, Ericka Meza, Cesar Ugarte-Gil, Nicholas Kiprotich, Lameck Diero, Ronald Tonui, Maria Lerm
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Tuberculosis (TB) poses a significant global health threat, with high mortality rates if left untreated. Current sputum-based TB treatment monitoring methods face numerous challenges, particularly in relation to sample collection and analysi
Externí odkaz:
https://doaj.org/article/ca69c2c9fd6149289d54030ad86da7cf
Autor:
Majid Pahlevan Kakhki, Antonino Giordano, Chiara Starvaggi Cucuzza, Tejaswi Venkata S. Badam, Samudyata Samudyata, Marianne Victoria Lemée, Pernilla Stridh, Asimenia Gkogka, Klementy Shchetynsky, Adil Harroud, Alexandra Gyllenberg, Yun Liu, Sanjaykumar Boddul, Tojo James, Melissa Sorosina, Massimo Filippi, Federica Esposito, Fredrik Wermeling, Mika Gustafsson, Patrizia Casaccia, Jan Hillert, Tomas Olsson, Ingrid Kockum, Carl M. Sellgren, Christelle Golzio, Lara Kular, Maja Jagodic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/335891136a424c99812fda12c3ca1d91
Autor:
Samuel Schäfer, Martin Smelik, Oleg Sysoev, Yelin Zhao, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Holger Heyn, Antonio Julia, István A. Kovács, Joseph Loscalzo, Sara Marsal, Huan Zhang, Xinxiu Li, Danuta Gawel, Hui Wang, Mikael Benson
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing based on characteri
Externí odkaz:
https://doaj.org/article/cc1c6e30e6e14966a03d083a086f0b98
Autor:
Julia Åkesson, Sara Hojjati, Sandra Hellberg, Johanna Raffetseder, Mohsen Khademi, Robert Rynkowski, Ingrid Kockum, Claudio Altafini, Zelmina Lubovac-Pilav, Johan Mellergård, Maria C. Jenmalm, Fredrik Piehl, Tomas Olsson, Jan Ernerudh, Mika Gustafsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Sensitive and reliable protein biomarkers are needed to predict disease trajectory and personalize treatment strategies for multiple sclerosis (MS). Here, we use the highly sensitive proximity-extension assay combined with next-generation se
Externí odkaz:
https://doaj.org/article/fca5c6e467d64332997f913572d4f0f4
Autor:
William Lövfors, Rasmus Magnusson, Cecilia Jönsson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Adipocyte signaling, normally and in type 2 diabetes, is far from fully understood. We have earlier developed detailed dynamic mathematical models for several well-studied, partially overlapping, signaling pathways in adipocytes. Still, thes
Externí odkaz:
https://doaj.org/article/cc9cf96f241a478db28a7eef0063ae70
Autor:
Alberto Zenere, Sandra Hellberg, Georgia Papapavlou Lingehed, Maria Svenvik, Johan Mellergård, Charlotte Dahle, Magnus Vrethem, Johanna Raffetseder, Mohsen Khademi, Tomas Olsson, Marie Blomberg, Maria C. Jenmalm, Claudio Altafini, Mika Gustafsson, Jan Ernerudh
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester of pregnancy. CD4+ and
Externí odkaz:
https://doaj.org/article/97e4780348e24d35a16031627d3a6a2d
Autor:
Tejaswi V. Badam, Sandra Hellberg, Ratnesh B. Mehta, Jeannette Lechner-Scott, Rodney A. Lea, Jorg Tost, Xavier Mariette, Judit Svensson-Arvelund, Colm E. Nestor, Mikael Benson, Göran Berg, Maria C. Jenmalm, Mika Gustafsson, Jan Ernerudh
Publikováno v:
Epigenetics, Vol 17, Iss 9, Pp 1040-1055 (2022)
Epigenetics may play a central, yet unexplored, role in the profound changes that the maternal immune system undergoes during pregnancy and could be involved in the pregnancy-induced modulation of several autoimmune diseases. We investigated changes
Externí odkaz:
https://doaj.org/article/82fde3e3be1f4925b203e0997ce02cf5
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Prediction algorithms for protein or gene structures, including transcription factor binding from sequence information, have been transformative in understanding gene regulation. Here we ask whether human transcriptomic profiles can be predi
Externí odkaz:
https://doaj.org/article/a89ba86959a3468baa159df13897b700
Autor:
Tejaswi V. S. Badam, Hendrik A. de Weerd, David Martínez-Enguita, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Maja Jagodic, Zelmina Lubovac-Pilav, Mika Gustafsson
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting genome-wide studies i
Externí odkaz:
https://doaj.org/article/a8a51bf9cef74d5e9df46fd05e3c45e9
Autor:
Rasmus Magnusson, Olof Rundquist, Min Jung Kim, Sandra Hellberg, Chan Hyun Na, Mikael Benson, David Gomez-Cabrero, Ingrid Kockum, Jesper N. Tegnér, Fredrik Piehl, Maja Jagodic, Johan Mellergård, Claudio Altafini, Jan Ernerudh, Maria C. Jenmalm, Colm E. Nestor, Min-Sik Kim, Mika Gustafsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Profiling of mRNA expression is an important method to identify biomarkers but complicated by limited correlations between mRNA expression and protein abundance. We hypothesised that these correlations could be improved by mathematical models based o
Externí odkaz:
https://doaj.org/article/382998380f194fbbbb24e92340e5edd7