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pro vyhledávání: '"Mik Bickis"'
Publikováno v:
Self/Nonself. 1:328-334
The hypothesis that mimicry between a self and a microbial peptide antigen is strictly related to autoimmune pathology remains a debated concept in autoimmunity research. Clear evidence for a causal link between molecular mimicry and autoimmunity is
Autor:
Reno Pontarollo, Chenhong Zhang, Shawn Babiuk, Mik Bickis, Benjamin Horseman, Anthony Kusalik, Mitchell S. Abrahamsen, Lawrence B. Schook
Publikováno v:
Immunogenetics. 59:167-176
Major histocompatibility complex class I genes are among the most polymorphic genes characterized. The high level of polymorphism is essential for generating host immune responses. In humans, three distinct genomic loci encode human leukocyte antigen
Publikováno v:
Peptides. 30(10)
The proteomes catalogued in the UniRef100 database were collected into a single proteome set and examined for actual versus theoretical pentapeptide occurrences. We found a highly diversified degree of pentapeptide redundancy. Numerically, 953 pentam
Publikováno v:
Immunome Research
Background: Peptides derived from endogenous antigens can bind to MHC class I molecules. Those which bind with high affinity can invoke a CD8+ immune response, resulting in the destruction of infected cells. Much work in immunoinformatics has involve