Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

Autor: Coffer PJ, de Jager W, van Loosdregt J, Klein M, Vastert B, Mijnheer G, Wehrens EJ, Prakken BJ, van Wijk F

Publikováno v: Pediatric Rheumatology Online Journal, Vol 9, Iss Suppl 1, p O7 (2011)

Externí odkaz: https://doaj.org/article/98515f293bf9458f83e8c8059804352c

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.

Autor: Mijnheer G; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Lutter L; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Mokry M; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, Department of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands.; Epigenomics facility, University Medical Center Utrecht, Utrecht, The Netherlands., van der Wal M; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Scholman R; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Fleskens V; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK., Pandit A; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Tao W; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Wekking M; Epigenomics facility, University Medical Center Utrecht, Utrecht, The Netherlands., Vervoort S; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Roberts C; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK., Petrelli A; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Peeters JGC; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Knijff M; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Roock S; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vastert S; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Taams LS; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK., van Loosdregt J; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., van Wijk F; Center for Translational Immunology, Pediatric Immunology & Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. f.vanwijk@umcutrecht.nl.

Publikováno v: Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2710. Date of Electronic Publication: 2021 May 11.

The 'T reg paradox' in inflammatory arthritis.

Autor: Schnell JT; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany., Briviesca RL; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Kim T; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Charbonnier LM; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Henderson LA; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., van Wijk F; Centre for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Nigrovic PA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA. peter.nigrovic@childrens.harvard.edu.; Division of Immunology, Boston Children's Hospital, Boston, MA, USA. peter.nigrovic@childrens.harvard.edu.

Publikováno v: Nature reviews. Rheumatology [Nat Rev Rheumatol] 2025 Jan; Vol. 21 (1), pp. 9-21. Date of Electronic Publication: 2024 Dec 09.

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PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

Autor: Petrelli A; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Mijnheer G; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Hoytema van Konijnenburg DP; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.; Laboratory of Mucosal Immunology, The Rockefeller University, New York, New York, USA., van der Wal MM; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Giovannone B; Department of Dermatology and Allergology., Mocholi E; Department of Cell Biology, Center for Molecular Medicine., Vazirpanah N; Department of Rheumatology and Clinical Immunology., Broen JC; Department of Rheumatology and Clinical Immunology., Hijnen D; Department of Dermatology and Allergology., Oldenburg B; Department of Gastroenterology and Hepatology, and., Coffer PJ; Department of Cell Biology, Center for Molecular Medicine., Vastert SJ; Department of Pediatrics, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Prakken BJ; Department of Pediatrics, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Spierings E; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Pandit A; Department of Rheumatology and Clinical Immunology., Mokry M; Department of Pediatric Gastroenterology, Division of Child Health, Wilhelmina Children's Hospital, Utrecht, Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands., van Wijk F; Department of Pediatrics, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Oct 01; Vol. 128 (10), pp. 4669-4681. Date of Electronic Publication: 2018 Aug 02.