Výsledky vyhledávání - "Miinalainen, I. (Ilkka)"

Dissertation/ Thesis

Enoyl thioester reductases—enzymes of fatty acid synthesis and degradation in mitochondria

Autor: Miinalainen, I. (Ilkka)

Fatty acids are one of the most essential categories of biological lipids and their synthesis and degradation are vital for all organisms. Severely compromised phenotypes of yeast mutants and human patients, which have defective components in their d

Externí odkaz: http://urn.fi/urn:isbn:9514282442

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Cooperation of angiopoietin-2 and angiopoietin-4 in Schlemm’s canal maintenance

Autor: Kapiainen, E. (Emmi), Elamaa, H. (Harri), Miinalainen, I. (Ilkka), Izzi, V. (Valerio), Eklund, L. (Lauri)

Purpose: Defects in the iridocorneal angle tissues, including the trabecular meshwork (TM) and Schlemm’s canal (SC), impair aqueous humor flow and increase the intraocular pressure (IOP), eventually resulting in glaucoma. Activation of endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::35701bb01b6a35bd581431c43ff25d3e
http://urn.fi/urn:nbn:fi-fe2022102062631

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Testis-specific thioredoxins TXNDC2, TXNDC3, and TXNDC6 are expressed in both testicular and systemic DLBCL and correlate with clinical disease presentation

Autor: Chan, M. C. (Mikko C.), Savela, J. (Janette), Ollikainen, R. K. (Riina K.), Teppo, H.-R. (Hanna-Riikka), Miinalainen, I. (Ilkka), Pirinen, R. (Risto), Kari, E. J. (Esa J. M.), Kuitunen, H. (Hanne), Turpeenniemi-Hujanen, T. (Taina), Kuittinen, O. (Outi), Kuusisto, M. E. (Milla E. L.)

DLBCL is the most common type of non-Hodgkin lymphoma with a substantial group of patients suffering a poor prognosis. Therefore more specific markers are required for better understanding of disease biology and treatment. This study demonstrates tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::f46fa63eb7fec776e178f8b7eb0b92b2
http://urn.fi/urn:nbn:fi-fe2021041610781

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The amino-terminal oligomerization domain of angiopoietin-2 affects vascular remodeling, mammary for gland tumor growth, and lung metastasis in mice

Autor: Kapiainen, E. (Emmi), Kihlström, M. K. (Minna K.), Pietilä, R. (Riikka), Kaakinen, M. (Mika), Ronkainen, V.-P. (Veli-Pekka), Tu, H. (Hongmin), Heikkinen, A. (Anne), Devarajan, R. (Raman), Miinalainen, I. (Ilkka), Laitakari, A. (Anna), Ansarizadeh, M. (Mohammadhassan), Zhang, Q. (Qin), Wei, G.-H. (Gong-Hong), Ruddock, L. (Lloyd), Pihlajaniemi, T. (Taina), Elamaa, H. (Harri), Eklund, L. (Lauri)

Angiopoietin-2 (ANGPT2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse responses in cancer. Blocking ANGPT2 provides a promising strategy for inhibiting tumor growth and metastasis, yet variable effects of targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::1d5ec30b371c5015194aa4e67a6433a2
http://urn.fi/urn:nbn:fi-fe2022022420723

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Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions

Autor: Vergauwen, G. (Glenn), Tulkens, J. (Joeri), Pinheiro, C. (Cláudio), Cobos, F. A. (Francisco Avila), Dedeyne, S. (Sándor), De Scheerder, M.-A. (Marie-Angélique), Vandekerckhove, L. (Linos), Impens, F. (Francis), Miinalainen, I. (Ilkka), Gevaert, K. (Kris), Mestdagh, P. (Pieter), Vandesompele, J. (Jo), Denys, H. (Hannelore), De Wever, O. (Olivier), Hendrix, A. (An)

Separating extracellular vesicles (EV) from blood plasma is challenging and complicates their biological understanding and biomarker development. In this study, we fractionate blood plasma by combining size-exclusion chromatography (SEC) and OptiPrep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::ebe8d2b0b72f6af7ecaf7bc17a32f59f
http://urn.fi/urn:nbn:fi-fe2021110453740

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Erbb4 regulates the oocyte microenvironment during folliculogenesis

Autor: Veikkolainen, V. (Ville), Ali, N. (Nsrein), Doroszko, M. (Milena), Kiviniemi, A. (Antti), Miinalainen, I. (Ilkka), Ohlsson, C. (Claes), Poutanen, M. (Matti), Rahman, N. (Nafis), Elenius, K. (Klaus), Vainio, S. J. (Seppo J.), Naillat, F. (Florence)

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders leading to infertility in women affecting reproductive, endocrine and metabolic systems. Recent genomewide association studies on PCOS cohorts revealed a single nucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::779053ad637745b7cbd2c262b0ef5ab2
http://urn.fi/urn:nbn:fi-fe2020112693299

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The critical effects of matrices on cultured carcinoma cells:human tumor-derived matrix promotes cell invasive properties

Autor: Wahbi, W. (Wafa), Naakka, E. (Erika), Tuomainen, K. (Katja), Suleymanova, I. (Ilida), Arpalahti, A. (Annamari), Miinalainen, I. (Ilkka), Väänänen, J. (Juho), Grenman, R. (Reidar), Monni, O. (Outi), Al-Samadi, A. (Ahmed), Salo, T. (Tuula)

The interaction between squamous cell carcinoma (SCC) cells and the tumor microenvironment (TME) plays a major role in cancer progression. Therefore, understanding the TME is essential for the development of cancer therapies. We used four (primary an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::741b58af2f1af4854a8258f9ae41c17b
http://urn.fi/urn:nbn:fi-fe2020051435636

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Correct expression and localization of collagen XIII are crucial for the normal formation and function of the neuromuscular system

Autor: Härönen, H. (Heli), Zainul, Z. (Zarin), Naumenko, N. (Nikolay), Sormunen, R. (Raija), Miinalainen, I. (Ilkka), Shakirzyanova, A. (Anastasia), Santoleri, S. (Sabrina), Kemppainen, A. V. (Antti V.), Giniatullin, R. (Rashid), Pihlajaniemi, T. (Taina), Heikkinen, A. (Anne)

Transmembrane collagen XIII has been linked to maturation of the musculoskeletal system. Its absence in mice (Col13a1−/−) results in impaired neuromuscular junction (NMJ) differentiation and function, while transgenic overexpression (Col13a1oe) l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::bb87aa78bb700e42dad58aaffe843b20
http://urn.fi/urn:nbn:fi-fe201902205808

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