Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mihoko Kajita"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional inte
Externí odkaz:
https://doaj.org/article/8ff80693d50442bea784cc1754aca29d
Autor:
Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1050-1060 (2017)
Summary: Autophagy is a lysosomal degradation pathway with important roles in physiological homeostasis and disease. However, the role of autophagy in intestinal stem cells (ISCs) is unclear. Here, we show that intrinsic autophagy in ISCs is importan
Externí odkaz:
https://doaj.org/article/824d54a616f044259b61f95edce8e18d
Autor:
Yoichiro Tamori, Carl Uli Bialucha, Ai-Guo Tian, Mihoko Kajita, Yi-Chun Huang, Mark Norman, Nicholas Harrison, John Poulton, Kenzo Ivanovitch, Lena Disch, Tao Liu, Wu-Min Deng, Yasuyuki Fujita
Publikováno v:
PLoS Biology, Vol 8, Iss 7, p e1000422 (2010)
During the initial stages of carcinogenesis, transformation events occur in a single cell within an epithelial monolayer. However, it remains unknown what happens at the interface between normal and transformed epithelial cells during this process. I
Externí odkaz:
https://doaj.org/article/ec3f346addc644b4afa1af3f00a06016
Autor:
Yusuke Ohba, Yuki Akieda, Takanobu Shirai, Ryutaro Akiyama, Yasuyuki Fujita, Yasuto Takeuchi, Yusuke Toyama, Mihoko Kajita, Takaaki Matsui, Yoichiroh Hosokawa, Masazumi Tada, Yoichiro Fujioka, Keisuke Kuromiya, Sohei Yamada, Susumu Ishikawa, Tohru Ishitani, Yukinari Haraoka, Elisa Vitiello, Rika Narumi, Nobuyuki Tanimura
Publikováno v:
Current biology. 30(4):670-681
When oncogenic transformation or apoptosis occurs within epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial homeostasis. However, the underlying molecular mechanism still remains elusive. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9b559d67182a1c0d61e14548cafae4
http://hdl.handle.net/2115/80478
http://hdl.handle.net/2115/80478
Autor:
Yukitaka Ishimoto, Mihoko Kajita, Yuki Ochi, Takaharu Okajima, Yasuyuki Fujita, Masahiro Tuchiya, Yuki Fujii
Publikováno v:
Biophysical Journal. 116:1152-1158
For isolated single cells on a substrate, the intracellular stiffness, which is often measured as the Young’s modulus, E, by atomic force microscopy (AFM), depends on the substrate rigidity. However, little is known about how the E of cells is infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f839dffa18e7d9b9cb2ea39ba9f9cb
https://doi.org/10.1016/j.bpj.2019.01.037
https://doi.org/10.1016/j.bpj.2019.01.037
Autor:
Toshiaki Ohteki, Taku Sato, Shun Ishikawa, Yuta Izumi, Shoko Kuroda, Masashi Kanayama, Takaei Shin, Mihoko Kajita, Yasuharu Yamauchi
Publikováno v:
Blood. 136(10)
Hematopoiesis is a system that provides red blood cells (RBCs), leukocytes, and platelets, which are essential for oxygen transport, biodefense, and hemostasis; its balance thus affects the outcome of various disorders. Here, we report that stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ab9f7702fd3afdee4e699960ce9250
https://pubmed.ncbi.nlm.nih.gov/32882015
https://pubmed.ncbi.nlm.nih.gov/32882015
Autor:
Yusuke Mori, Yoichiro Tamori, Mihoko Kajita, Koki Kohashi, Susumu Ishikawa, Tomoko Kamasaki, Kei Kozawa, Rika Narumi, Yasuyuki Fujita, Rei Kobayashi
Publikováno v:
Current Biology. 31:3984-3995.e5
At the initial stage of carcinogenesis, newly emerging transformed cells are often eliminated from epithelial layers via cell competition with the surrounding normal cells. For instance, when surrounded by normal cells, oncoprotein RasV12-transformed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962d616655c586fcba203ffd5587a9a7
https://doi.org/10.1016/j.cub.2021.06.064
https://doi.org/10.1016/j.cub.2021.06.064
Autor:
Toshiaki Ohteki, Taku Sato, Jumpei Asano, Shigeomi Shimizu, Mihoko Kajita, Shizuko Ichinose, Nobuyuki Onai
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1050-1060 (2017)
Summary: Autophagy is a lysosomal degradation pathway with important roles in physiological homeostasis and disease. However, the role of autophagy in intestinal stem cells (ISCs) is unclear. Here, we show that intrinsic autophagy in ISCs is importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82500cd82bd39fde6ec1f11827617750
https://doi.org/10.1016/j.celrep.2017.07.019
https://doi.org/10.1016/j.celrep.2017.07.019
Autor:
Jun-ichi Miyazaki, Masaru Ishii, Shunsuke Kon, Michael R. Duchen, Tomohiro Matsumoto, Eisuke Nishida, Masanobu Oshima, Riku Egami, Tomoko Kamasaki, Hiroto Katoh, Yusuke Ohba, Mihoko Kajita, Shingo Yoshioka, Rika Narumi, Takanobu Shirai, Tomoko Morita, Junichi Kikuta, Yoshiteru Sasaki, Toshiro Sato, Kojiro Ishibashi, Sato Honma, Sho Kitamoto, Yasuyuki Fujita, Ayana Sasaki, Hirotaka Watanabe, Masamichi Imajo, Susumu Ishikawa, Ryosuke Enoki, Shinya Tanaka, Jin Min Nam, Ikumi Kameda, Yasuhito Onodera, Hajime Yamauchi, Takeshi Maruyama, Hiromi Imamura, Atsuko Nishikawa, Yoichiro Fujioka, Tomoyoshi Soga, Yuta Yako
Publikováno v:
Nature Cell Biology. 19:530-541
Recent studies have revealed that newly emerging transformed cells are often apically extruded from epithelial tissues. During this process, normal epithelial cells can recognize and actively eliminate transformed cells, a process called epithelial d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e8dd06fd680f0798aba29cde412278
https://doi.org/10.1038/ncb3509
https://doi.org/10.1038/ncb3509
Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
Autor:
Jumpei Asano, Toshiaki Ohteki, Shun Ishikawa, Toshiro Sato, Yoshiyuki Mori, Taku Sato, Mihoko Kajita, Miwako Sase
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
The small intestine has a robust regenerative capacity, and various cell types serve as “cells-of-origin” in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e8209a0693035a2b8ef9bfd80f8b0
https://pubmed.ncbi.nlm.nih.gov/32444673
https://pubmed.ncbi.nlm.nih.gov/32444673