Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Miho Watanabe-Takahashi"'
Autor:
Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, Kiyotaka Nishikawa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
Externí odkaz:
https://doaj.org/article/18881887888349608aa45d5d46a40371
Autor:
Ying-Yi Li, Kazuyuki Kuroki, Tetsuro Shimakami, Kazuhisa Murai, Kazunori Kawaguchi, Takayoshi Shirasaki, Kouki Nio, Saiho Sugimoto, Tomoki Nishikawa, Hikari Okada, Noriaki Orita, Hideo Takayama, Ying Wang, Phuong Doan Thi Bich, Astuya Ishida, Sadahiro Iwabuchi, Shinichi Hashimoto, Takeshi Shimaoka, Noriko Tabata, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Hiroshi Yanagawa, Motoharu Seiki, Kouji Matsushima, Taro Yamashita, Shuichi Kaneko, Masao Honda
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 533-558 (2023)
Background & Aims: Hepatitis B virus (HBV) infection is difficult to cure owing to the persistence of covalently closed circular viral DNA (cccDNA). We performed single-cell transcriptome analysis of newly established HBV-positive and HBV-negative he
Externí odkaz:
https://doaj.org/article/5994dbd6cb574256b719639b085d8fe8
Autor:
Miho Watanabe-Takahashi, Miki Senda, Ryunosuke Yoshino, Masahiro Hibino, Shinichiro Hama, Tohru Terada, Kentaro Shimizu, Toshiya Senda, Kiyotaka Nishikawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), can cause fatal systemic complications. Recently, we identified a potent inhibitory peptide that binds to the catalytic A-subunit of Stx. Here, using b
Externí odkaz:
https://doaj.org/article/c2782278432e409e8b97ae9a82df8762
Autor:
Miho Watanabe-Takahashi, Masakazu Tamada, Miki Senda, Masahiro Hibino, Eiko Shimizu, Akiko Okuta, Atsuo Miyazawa, Toshiya Senda, Kiyotaka Nishikawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Watanabe-Takahashi, Tamada, Senda et al. identify a tetravalent peptide that inhibits Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli, by targeting its receptor-binding. On the other hand, a monomeric peptide contain
Externí odkaz:
https://doaj.org/article/bbdaed596a724d62b77588f4c9ef5bc4
The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
Autor:
Jumpei Omi, Miho Watanabe-Takahashi, Katsura Igai, Eiko Shimizu, Ching-Yi Tseng, Tomohiro Miyasaka, Tsuyoshi Waku, Shinichiro Hama, Rieka Nakanishi, Yuki Goto, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Makoto Yamashita, Kiyotaka Nishikawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into am
Externí odkaz:
https://doaj.org/article/cf5c2b2aa01a4b1b81e53280acad9dd5
Autor:
Takayuki Hattori, Miho Watanabe-Takahashi, Nobumichi Ohoka, Takashi Hamabata, Koichi Furukawa, Kiyotaka Nishikawa, Mikihiko Naito
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 605-614 (2015)
Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short‐lived anti‐apoptotic proteins followed by activation of caspase 9 and the pro
Externí odkaz:
https://doaj.org/article/ebecadba8aa649e482b5311dbbaf953a
Autor:
Rina Ogawa, Kohjiro Nagao, Kentaro Taniuchi, Masaki Tsuchiya, Utako Kato, Yuji Hara, Takehiko Inaba, Toshihide Kobayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Masato Umeda
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131668 (2015)
We employed a multivalent peptide-library screening technique to identify a peptide motif that binds to phosphatidic acid (PA), but not to other phospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS
Externí odkaz:
https://doaj.org/article/2680847878f54b7facf76d25477d6d04
Autor:
Atsuko Deguchi, Miho Watanabe-Takahashi, Taishi Mishima, Tsutomu Omori, Umeharu Ohto, Nobuto Arashiki, Fumio Nakamura, Kiyotaka Nishikawa, Yoshiro Maru
Publikováno v:
Cancer Gene Therapy.
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9187d65934590ca27f1a9ed9d7ea50f8
https://doi.org/10.1038/s41417-023-00604-3
https://doi.org/10.1038/s41417-023-00604-3
Autor:
Masataka Anzai, Miho Watanabe-Takahashi, Hiroshi Kawabata, Saori Mizuno, Yuu Taguchi, Jun-ichiro Inoue, Kiyotaka Nishikawa
Publikováno v:
Biochemical and biophysical research communications. 636(Pt 1)
Inhibition of osteoclast differentiation is a promising approach for the treatment of osteoporosis and rheumatoid arthritis. Receptor activator of nuclear factor kappa B (NF-κB) (RANK), which is an essential molecule for osteoclast differentiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffd9d19e7a2cb7c450816f0bb29c87a
https://pubmed.ncbi.nlm.nih.gov/36334442
https://pubmed.ncbi.nlm.nih.gov/36334442
Autor:
Satoru Funamoto, Koichi Furukawa, Waka Sato, Takashi Hamabata, Kiyotaka Nishikawa, Miho Watanabe-Takahashi
Publikováno v:
Biochemical and Biophysical Research Communications. 557:247-253
Accumulation of amyloid-β peptide (Aβ) in neuronal cells and in the extracellular regions in the brain is a major cause of Alzheimer's disease (AD); therefore, inhibition of Aβ accumulation offers a promising approach for therapeutic strategies ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a593542b6a194126a45af9789b3fc3b
https://doi.org/10.1016/j.bbrc.2021.04.015
https://doi.org/10.1016/j.bbrc.2021.04.015