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pro vyhledávání: '"Miho Takaoka"'
Cytokinesis is the critical final step in cell division. BRCA2 disruption during cytokinesis is associated with chromosome instability, but mechanistic information is lacking that could be used to prevent cancer cell division. In this study, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::676bb28746665f9e7ecf91b09d62ec1a
https://doi.org/10.1158/0008-5472.c.6505998
https://doi.org/10.1158/0008-5472.c.6505998
PDF file - 201K, Abnormal cytokinesis following BRCA2 or NM-IIC gene silencing (Related to Figure 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71774d2314cbff0691ece7bd06cfce8d
https://doi.org/10.1158/0008-5472.22402149
https://doi.org/10.1158/0008-5472.22402149
PDF file - 98K, NM-IIC-ATPase activity enhanced in the presence of BRCA2 is required for IIC-ring formation. (Related to Figure 5).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdf54de05fff8953130fc629e78121e
https://doi.org/10.1158/0008-5472.22402140
https://doi.org/10.1158/0008-5472.22402140
PDF file - 148K, BRCA1 gene silencing had no influence on the formation of midbody. (Related to Figure 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c07880d6bfb843b3d1a6e14ffb3b23e
https://doi.org/10.1158/0008-5472.22402146
https://doi.org/10.1158/0008-5472.22402146
PDF file - 133K, The phosphorylation of BRCA2 N-terminus by Plk1 is important for BRCA2 localization to the Flemming body. (Related to Figure 1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5c415d051d42fd8f5bcee5ebfc6608
https://doi.org/10.1158/0008-5472.22402155
https://doi.org/10.1158/0008-5472.22402155
PDF file - 95K, The subcellular localization of the NM-IIC during cytokinesis, and its interaction with BRCA2 (Related to Figure 2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d7929b12b7d8a6d2664fa88009cb3
https://doi.org/10.1158/0008-5472.22402152
https://doi.org/10.1158/0008-5472.22402152
PDF file - 106K, Abnormal midbody and binucleated cells induced by expression of NM-IIC (A1) or BRCA2 (R1) (Related to Figure 4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bf690da3faaba91db3e35742030f08
https://doi.org/10.1158/0008-5472.22402143
https://doi.org/10.1158/0008-5472.22402143
Publikováno v:
Cell Cycle
BRCA2 is responsible for familial breast and ovarian cancer and has been linked to DNA repair and centrosome duplication. Here we analyzed the mechanism by which the centrosomal localization signal (CLS) of BRCA2 interacts with cytoplasmic dynein 1 t
Autor:
Yoshio Miki, Miho Takaoka
Publikováno v:
International journal of clinical oncology. 23(1)
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but he