Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Miho Nagayasu"'
Autor:
Kouichi Yoshinari, Atsushi Suda, Ohminato Noriaki, Kazuhisa Ozeki, Naomi Ono, Norihito Shibahara, Miho Nagayasu, Ryoichi Saitoh
Publikováno v:
Xenobiotica. 51:968-976
The in vitro antitumor activity (e.g., IC50) of anticancer drugs is important for selecting candidate compounds for in vivo drug efficacy study in the early stage of drug discovery. In this study, ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df393edd10bacfa3dbee95f16f24bee
https://doi.org/10.1080/00498254.2021.1942588
https://doi.org/10.1080/00498254.2021.1942588
Autor:
Kazuhisa Ozeki, Miho Nagayasu
Publikováno v:
Pharmaceutical Research. 38:583-592
The aim of this study was to develop a useful antibody PK evaluation tool using a combination of cassette-dosing and microsampling in mice and monkeys in order to reduce the number of animals used. Cetuximab, denosumab, infliximab, and a mixture of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a31d6e46a2d9377c2800475755fa202
https://doi.org/10.1007/s11095-021-03028-6
https://doi.org/10.1007/s11095-021-03028-6
Autor:
Takeru Nambu, Kazuhisa Ozeki, Takayuki Nemoto, Ken Ichi Hosoya, Miho Nagayasu, Genki Nakamura
Publikováno v:
Biologicalpharmaceutical bulletin. 43(5)
Efficiency (speed and cost) and animal welfare are important factors in the development of new drugs. A novel method (the half-life method) was developed to predict the human plasma concentration-time profile of a monoclonal antibody (mAb) after intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f2a4ccae230ec58502b9b4b78b3677
https://pubmed.ncbi.nlm.nih.gov/32378559
https://pubmed.ncbi.nlm.nih.gov/32378559
Publikováno v:
Pharmaceutical research. 37(1)
Multiple time-point sampling is required in transcellular transport studies to accurately calculate the appropriate efflux ratio (ER). Our study sought to develop a simplified method to determine the ER in Caco-2 cells. The equation for the ER was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b653be58cce0f52873c6fb3ab60d0b
https://pubmed.ncbi.nlm.nih.gov/31873817
https://pubmed.ncbi.nlm.nih.gov/31873817
Publikováno v:
Biologicalpharmaceutical bulletin. 42(9)
The purpose of this study was to establish a modified method of three-compartment model analysis that minimized the sampling frequency. A Caco-2 permeability assay was performed on ten structurally diverse compounds with passive diffusion. A three-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ab18988f51cde49058b177e60dbc5a
https://pubmed.ncbi.nlm.nih.gov/31474721
https://pubmed.ncbi.nlm.nih.gov/31474721
Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment
Autor:
Etsuko Fujii, Junichi Kikuta, Masayuki Matsushita, Miho Ayabe, Masaru Ishii, Shojiro Kadono, Naoaki Murao, Futa Mimoto, Terushige Muraoka, Yuki Suzuki, Hitoshi Katada, Kunihiro Hattori, Kazuhisa Ozeki, Atsuhiko Kato, Takeru Nambu, Masami Hasegawa, Yumiko Azuma, Mika Kamata-Sakurai, Mika Endo, Takayuki Kamikawa, Tanba Shigero, Akira Hayasaka, Miho Nagayasu, Kenji Nakagawa, Tomoyuki Igawa, Tessai Yamamoto, Hiroaki Susumu, Kanako Tatsumi, Tatsuya Kibayashi, Kenta Haraya, Kazuhiro Ohara, Shun Shimizu, Takahiro Ishiguro, Eriko Tanaka, Kosuke Aso, Hiroki Kawauchi, Kamimura Masaki, Yasushi Tomii, Sakashita Takuya, Takeshi Baba
Publikováno v:
Cell Reports. 33:108542
The extracellular adenosine triphosphate (ATP) concentration is highly elevated in the tumor microenvironment (TME) and remains tightly regulated in normal tissues. Using phage display technology, we establish a method to identify an antibody that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8d65758b79254f62952e632e1d8f7f
https://doi.org/10.1016/j.celrep.2020.108542
https://doi.org/10.1016/j.celrep.2020.108542
Autor:
Makoto Okazaki, John T. Potts, Kenji Adachi, Hiroshi Noda, Miho Nagayasu, Thomas J. Gardella, Masaru Shimizu, Tomoyuki Watanabe, Tatsuya Tamura, Eri Joyashiki, Yoshiki Kawabe
Publikováno v:
Journal of Bone and Mineral Research. 31:1405-1412
Hypoparathyroidism is a disease of chronic hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone (PTH). PTH and analogs of the hormone are of interest as potential therapies. Accordingly, we examined the pharmacological proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e149aebc7e5903ef93f866ddc0cce3a
https://doi.org/10.1002/jbmr.2811
https://doi.org/10.1002/jbmr.2811
Autor:
Ken Takagi, Miho Nagayasu
Publikováno v:
Ocean Engineering. 34:362-370
The conceptual design of a very large floating structure (VLFS) requires a convenient computer code for predicting hydroelastic behavior of it. The code should not be time consuming, but it should be flexible for all environmental conditions. In orde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a30cd9cbf6a19de7f76550b29ca3c0
https://doi.org/10.1016/j.oceaneng.2005.05.017
https://doi.org/10.1016/j.oceaneng.2005.05.017
Autor:
Shuji Hayashi, Miho Nagayasu, Shuichi Chiba, Tomochika Matsushita, Yuichiro Yamada, Kazuya Kimura, Chisako Kanamaru, Atsushi Suda
Publikováno v:
The Journal of toxicological sciences. 39(1)
Heat shock protein 90 (Hsp90) is a constitutively expressed molecular chaperone and plays an important role in the folding of client proteins with key regulatory roles in growth, survival, differentiation and metastasis. Because inhibition of Hsp90 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d854b9d64835d885a76b1594f26183
https://pubmed.ncbi.nlm.nih.gov/24418710
https://pubmed.ncbi.nlm.nih.gov/24418710
Autor:
Ryoichi Saitoh, Masaki Ishigai, Miho Nagayasu, Naomi Ono, Norihito Shibahara, Motohiro Kato, Atsushi Suda
Publikováno v:
Drug metabolism and pharmacokinetics. 29(2)
Summary: The purpose of this study is to assess the impact of human epidermal growth factor receptor 2 (HER2) status on the antitumor activity of CH5164840, an orally available heat shock protein 90 (HSP90) inhibitor, using pharmacokinetic–pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0752e1be14709780d12f69f18a0ea44
https://pubmed.ncbi.nlm.nih.gov/24126359
https://pubmed.ncbi.nlm.nih.gov/24126359