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pro vyhledávání: '"Miho Mesaki"'
Publikováno v:
Biochemical Journal. 380:95-103
Recent advances suggest that the molecular components of the circadian clock generate a self-sustaining transcriptional–translational feedback loop with a period of approx. 24 h. The precise expression profiles of human clock genes and their produc
Publikováno v:
Molecular and Cellular Biology. 21:6651-6659
Mammalian PERIOD2 protein (PER2) is the product of a clock gene that controls circadian rhythms, because PER2-deficient mice have an arrhythmic phenotype. The nuclear entry regulation of clock gene products is a key step in proper circadian rhythm fo
Autor:
Chisato Iitaka, Miho Mesaki, Yoshihisa Shimizu, G Atsumi, Katsutaka Oishi, Takeshi Todo, Norio Ishida, Shima Yukimasa, Hisato Kobayashi, Naoki Ohkura, Takashi Kudo, Takahiro Nagase, Kazuhiko Machida, Takashi Umehara, Morito Monden, Takashi Azama, Shuichi Horie, Juzo Matsuda, Koyomi Miyazaki, Masami Horikoshi, Reiko Kikuno, Masahiko Yano, Koji Kadota
Publikováno v:
The Journal of biological chemistry. 278(42)
CLOCK is a positive component of a transcription/translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we perf