Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Miho Iijima"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109874- (2024)
Summary: Mitochondrial division controls the size, distribution, and turnover of this essential organelle. A dynamin-related GTPase, Drp1, drives membrane division as a force-generating mechano-chemical enzyme. Drp1 is regulated by multiple mechanism
Externí odkaz:
https://doaj.org/article/d341d71fc5d74707a11058cc77e06b01
Autor:
Balamurugan Ramatchandirin, Miho Iijima, Arisa Ikeda, Alexia Pearah, Sally Radovick, Fredric E. Wondisford, Hiromi Sesaki, Ling He
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102842- (2024)
Summary: Mitochondrial dynamic process is important for cell viability, metabolic activity, and mitochondria health. Here, we present a protocol for measuring mitochondrial size through immunofluorescence staining, confocal imaging, and analysis in I
Externí odkaz:
https://doaj.org/article/e2b2379170a54ed2982c28a9e26ce39d
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106067- (2023)
Summary: The human mtHSP60/HSPD1-mtHSP10/HSPE1 system prevents protein misfolding and maintains proteostasis in the mitochondrial matrix. Altered activities of this chaperonin system have been implicated in human diseases, such as cancer and neurodeg
Externí odkaz:
https://doaj.org/article/5bcc28de24bc4ee5a79a01fb7209eb31
Autor:
Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes, Min Zhao
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Background Cells show directed migration response to electric signals, namely electrotaxis or galvanotaxis. PI3K and PTEN jointly play counterbalancing roles in this event via a bilateral regulation of PIP3 signaling. PI3K has been proved es
Externí odkaz:
https://doaj.org/article/3245821e91824788b14cb2c4e7503980
Autor:
Tatsuya Yamada, Daisuke Murata, David E. Kleiner, Robert Anders, Avi Z. Rosenberg, Jeffrey Kaplan, James P. Hamilton, Mariam Aghajan, Moshe Levi, Nae-Yuh Wang, Ted M. Dawson, Toru Yanagawa, Andrew F. Powers, Miho Iijima, Hiromi Sesaki
Publikováno v:
iScience, Vol 25, Iss 4, Pp 103996- (2022)
Summary: Non-alcoholic steatohepatitis (NASH) is a most common chronic liver disease that is manifested by steatosis, inflammation, fibrosis, and tissue damage. Hepatocytes produce giant mitochondria termed megamitochondria in patients with NASH. It
Externí odkaz:
https://doaj.org/article/0fae080557bb4652bb50c5207550ede1
Autor:
Takashi Kato, Tatsuya Yamada, Hideki Nakamura, Atsushi Igarashi, Robert A. Anders, Hiromi Sesaki, Miho Iijima
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101548- (2020)
Summary: The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in t
Externí odkaz:
https://doaj.org/article/75a54c88a8fb4752b12605a6333b6985
Autor:
Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes, Min Zhao
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/d6d55aad01164091aa71ddb4088d2407
Autor:
Nikoleta Tellios, Jillian C. Belrose, Alexander C. Tokarewicz, Cindy Hutnik, Hong Liu, Andrew Leask, Michael Motolko, Miho Iijima, Sunil K. Parapuram
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical s
Externí odkaz:
https://doaj.org/article/8bb48815166d45aeb9c93eacf9646328
Autor:
Kie Itoh, Daisuke Murata, Takashi Kato, Tatsuya Yamada, Yoichi Araki, Atsushi Saito, Yoshihiro Adachi, Atsushi Igarashi, Shuo Li, Mikhail Pletnikov, Richard L Huganir, Shigeki Watanabe, Atsushi Kamiya, Miho Iijima, Hiromi Sesaki
Publikováno v:
eLife, Vol 8 (2019)
Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One such isoform, Drp1ABCD,
Externí odkaz:
https://doaj.org/article/d127a1b7a9bc4de8a744e7a0583a8eba
Publikováno v:
Bio-Protocol, Vol 7, Iss 9 (2017)
A mitochondrion is a dynamic intracellular organelle that actively divides and fuses to control its size, number and shape in cells. A regulated balance between mitochondrial division and fusion is fundamental to the function, distribution and turnov
Externí odkaz:
https://doaj.org/article/1af81092cf5b4cb3bd48ccb5ae271ba4