Výsledky vyhledávání

Akademický článek

Pretreatment with KGA-2727, a selective SGLT1 inhibitor, is protective against myocardial infarction-induced ventricular remodeling and heart failure in mice

Autor: Yohei Sawa, Maki Saito, Nanae Ishida, Miho Ibi, Naoko Matsushita, Yoshihiro Morino, Eiichi Taira, Masamichi Hirose

Publikováno v: Journal of Pharmacological Sciences, Vol 142, Iss 1, Pp 16-25 (2020)

Recent studies demonstrated that sodium-glucose co-transporter 1 (SGLT1) is associated with human ischemic cardiomyopathy. However, whether SGLT1 blockade is effective against ischemic cardiomyopathy is still uncertain. We examined the effects of KGA

Externí odkaz: https://doaj.org/article/8781f89ea6d64226b12dd58104ca0221

Zobrazit plný text záznamu

Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint

Autor: Kanna Asanuma, Seiji Yokota, Naoyuki Chosa, Masaharu Kamo, Miho Ibi, Hisayo Mayama, Tarou Irié, Kazuro Satoh, Akira Ishisaki

Publikováno v: Journal of oral biosciences.

Temporomandibular joint osteoarthritis (TMJ-OA) is a multifactorial disease caused by inflammation and oxidative stress. It has been hypothesized that mechanical stress-induced injury of TMJ tissues induces the generation of reactive oxygen species (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e473058256554ffaa71db6cec6f8ad
https://pubmed.ncbi.nlm.nih.gov/36584898

Zobrazit plný text záznamu

Pretreatment with KGA-2727, a selective SGLT1 inhibitor, is protective against myocardial infarction-induced ventricular remodeling and heart failure in mice

Autor: Masamichi Hirose, Maki Saito, Naoko Matsushita, Miho Ibi, Eiichi Taira, Yoshihiro Morino, Yohei Sawa, Nanae Ishida

Publikováno v: Journal of Pharmacological Sciences, Vol 142, Iss 1, Pp 16-25 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9b5aad4cfd8ae0297c31b2334f81e
http://www.sciencedirect.com/science/article/pii/S1347861319357263

Zobrazit plný text záznamu

IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice

Autor: Miho Ibi, Nanae Ishida, Yoshihiro Morino, Yohei Sawa, Masamichi Hirose, Eiichi Taira, Masafumi Takahashi, Maki Saito, Yoichiro Iwakura, Shun'ichiro Taniguchi, Naoko Matsushita

Publikováno v: Biological and Pharmaceutical Bulletin. 42:543-546

Hypertension is one risk for atrial fibrillation (AF) and induces cardiac inflammation. Recent evidence indicates that pressure overload-induced ventricular structural remodeling is associated with the activation of nucleotide binding-oligomerization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939760bb5b54dbe329b0c0c07b8cf90b
https://doi.org/10.1248/bpb.b18-00363

Zobrazit plný text záznamu

8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice

Autor: Maki Saito, Masamichi Hirose, Hidetoshi Yamada, Miho Ibi, Nanae Ishida

Publikováno v: Biologicalpharmaceutical bulletin. 43(6)

Eicosapentaenoic acid (EPA), one of the N-3 polyunsaturated fatty acids (n-3 PUFAs), is a major active ingredient of fish that contributes to improve dyslipidemia. Recently, we demonstrated that 8-hydroxyeicosapentaenoic acid (8-HEPE) had a more posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334aade08533ac08a6d5fcc84a399395
https://pubmed.ncbi.nlm.nih.gov/32475913

Zobrazit plný text záznamu

Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice

Autor: Nanae Ishida, Hermann Koepsell, Eiichi Taira, Yasuchika Takeishi, Yohei Sawa, Naoko Matsushita, Satoshi Suzuki, Hisashi Shimojo, Miho Ibi, Maki Saito, Masamichi Hirose, Atsushi Sanbe, Yoshihiro Morino

Publikováno v: International Heart Journal. 59:1123-1133

Increased gene expression levels of sodium-glucose cotransporter 1 (SGLT1) are associated with hypertrophic and ischemic cardiomyopathy. However, it remains unclear whether chronic pressure overload increases SGLT1 expression, which in turn induces h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bcc558decb285a9f462aa258cadecdb
https://doi.org/10.1536/ihj.17-565

Zobrazit plný text záznamu

PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner

Autor: Toshiyuki Fukada, Kenji Mishima, Masayuki Azuma, Keiko Aota, Miho Ibi, Rika Yasuhara, Yuriko Goto, Tarou Irie, Hirotaka Sato, Junichi Tanaka

Publikováno v: Journal of oral biosciences. 62(1)

Objectives: Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo. Herein, we demonstrate the roles of PLAG1 in the acinar and ductal cells of normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ffd81afbec2619ddbf201692f538fa
https://pubmed.ncbi.nlm.nih.gov/32007659

Zobrazit plný text záznamu

Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture

Autor: Masato Ohtsuka, Naoto Okubo, Takashi Yaegashi, Masaharu Kamo, Toshinari Mikami, Akira Ishisaki, Keita Suzuki, Miho Ibi, Seiko Kyakumoto, Masayuki Taira, Naoyuki Chosa, Seiji Yokota, Naoki Takizawa

Publikováno v: Experimental Cell Research. 358:411-420

Immunosuppressive/anti-inflammatory macrophage (Mφ), M2-Mφ that expressed the typical M2-Mφs marker, CD206, and anti-inflammatory cytokine, interleukin (IL)-10, is beneficial and expected tool for the cytotherapy against inflammatory diseases. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737125f1117bdd09d24b58a53c7f4a39
https://doi.org/10.1016/j.yexcr.2017.07.014

Zobrazit plný text záznamu

ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint

Autor: Seiji Yokota, Miho Ibi, Akira Ishisaki, Naoyuki Chosa, Kazuro Satoh, Masaharu Kamo, Seiko Kyakumoto, Hitomichi Kimura

Publikováno v: International Journal of Molecular Medicine

Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the temporomandibular joint (TMJ). Excessive mechanical stress against soft and hard tissues around

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9393370d24563669b93a3c7a2b65359e
https://doi.org/10.3892/ijmm.2017.2896

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání